Effect of calcium peroxide particles as oxygen-releasing materials on cell growth and mechanical properties of scaffolds for tissue engineering

Mollajavadi, Mohammad Yasin; Saadatmand, Maryam; Ghobadi, Faezeh

doi:10.1007/s13726-023-01147-y

Cited by 7 publications

(7 citation statements)

References 36 publications

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“…However, it can be observed that the increase in CPO NPs concentration increased the porosity in the scaffold. This is mostly due to the size of the nanoparticles, which causes a reduced distance between them and the porous structure [23,25].…”

Section: Morphological Analysis Of Fabricated Scaffoldsmentioning

confidence: 99%

“…However, a significant problem associated with traditional polymeric scaffolds for BTE is to maintain cell growth within a 3D scaffold before local vascularization due to the lack of oxygen supply (hypoxic condition) and keeping an aseptic environment [22][23][24][25]. Incorporating the oxygen-releasing property in bone tissue scaffold for local tissue regeneration can be a novel approach to managing the local oxidative stress at the bone defect site, boosting cell proliferation and differentiation while decreasing bacterial infection [26][27][28].…”

Section: Introductionmentioning

confidence: 99%

“…Incorporating the oxygen-releasing property in bone tissue scaffold for local tissue regeneration can be a novel approach to managing the local oxidative stress at the bone defect site, boosting cell proliferation and differentiation while decreasing bacterial infection [26][27][28]. Recently, researchers have explored the use of oxygen-releasing calcium peroxide (CPO) nanomaterial to tackle oxidative stress at the implanted site to expedite healing [22][23][24][25]. CPO contains calcium and oxygen, and it is often used as an adequate source of local oxygen and calcium supply.…”

Section: Introductionmentioning

confidence: 99%

“…CPO contains calcium and oxygen, and it is often used as an adequate source of local oxygen and calcium supply. It is essential for forming new blood vessels in the regenerating tissue, expediting bone growth and healing [22][23][24][25]. In vitro studies have reported that the CPO-based oxygen-releasing scaffold not only supports the osteoblasts adhesion, proliferation, differentiation, and local bone tissue mineralization but also promotes new blood vessel formation.…”

Section: Introductionmentioning

confidence: 99%

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Nanoengineered oxygen-releasing polymeric scaffold with sustained release of dexamethasone for bone regeneration

Vahora,

Singh,

Dan

et al. 2024

Biomed. Mater.

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Maintaining the continuous oxygen supply and proper cell growth before blood vessel ingrowth at the bone defect site are considerably significant issues in bone regeneration. Oxygen-producing scaffolds can supply oxygen and avoid hypoxia leading to expedited bone regeneration. Herein, first oxygen-producing calcium peroxide nanoparticles (CPO NPs) are synthesized, and subsequently, the various amounts of synthesized CPO NPs (0.1, 0.5, and 1wt/v%) loaded in the scaffold composite, which is developed by simple physical blending of chitosan (CS) and polycaprolactone (PCL) polymers. To deliver the synergistic therapeutic effect, dexamethasone (DEX), known for its potential anti-inflammatory and osteogenic properties, is loaded into the nanocomposite scaffolds. The extensive physicochemical characterizations of nanocomposite scaffolds confirm the successful loading of CPO NPs, adequate porous morphology, pore size, hydrophilicity, and biodegradability. In vitro, biological studies support the antibacterial, hemocompatible, and cytocompatible (MG-63 and MC3T3-E1 cells) nature of the material when tested on respective cells. FE-SEM and Energy-dispersive X-ray spectroscopy confirm the successful biomineralization of the scaffolds. Scaffolds also exhibit the sustained release of DEX and efficient protein adsorption. This study revealed that a nanoengineered scaffold loaded with CPO NPs (PCL/CS/DEX/CPO 3) is a suitable candidate for bone tissue regeneration.

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Section: Morphological Analysis Of Fabricated Scaffoldsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Nanoengineered oxygen-releasing polymeric scaffold with sustained release of dexamethasone for bone regeneration

Vahora,

Singh,

Dan

et al. 2024

Biomed. Mater.

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“…Hydrogels are useful and attractive materials for biomedical scientists because of their high water content. They are suitable for cell culture and tissue engineering because of their favorable oxygen and nutrient transport 34–36 . Hydrogels have a similar structure to biological soft tissues and can be used to resemble an extracellular matrix 37 .…”

Section: Introductionmentioning

confidence: 99%

Self‐healing polymers containing nanomaterials for biomedical engineering applications: A review

Mollajavadi,

Tarigheh,

Eslami‐Farsani

2023

Polymer Composites

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Materials that can recover the function of lost or damaged parts, called self‐healing materials, have attracted attention due to their wide usage in different fields such as water refinery, coatings, robotics, and especially, biomedical applications. Depending on whether the self‐healing component is added to the polymer or is inherent to the polymeric matrix, the self‐healing properties of the polymeric materials can be classified into extrinsic and intrinsic self‐healing. Hydrogels are one of the most used polymers in self‐healing applications for various purposes, including tissue engineering, drug delivery, etc. Nanoparticles can endow some essential features to hydrogels, such as improving mechanical properties, more efficient healing ability, conductivity, and antibacterial and magnetic features. In the current study, various biomedical applications of self‐healing polymers using nanoparticles are discussed in detail, showing the impact of addition of nanoparticles. Perfect antibacterial properties with the addition of copper sulfide or silver nanoparticles were achieved. In addition, enhancing compression modulus up to three times and endowing conductivity to the hydrogel as the effect of carbon nanotube addition and better mechanical properties caused by graphene oxide and iron oxide nanoparticles were reported. These are just a few examples of the results achieved by adding nanoparticles to the self‐healing polymers described in this study.

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Microneedles for Enhanced Bacterial Pathogen Inactivation and Accelerated Wound Healing

Krishnakumar,

Gallina,

Sarnaik

et al. 2024

Adv Materials Technologies

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Bacterial wound infections are a significant socioeconomic concern in the modern healthcare industry owing to increased morbidity, prolonged hospital stay, and mortality. Bacterial infectious agents that colonize the wound bed develop biofilms, acting as a physical barrier that prevents the effective penetration of topical antimicrobials. Further, bacteria in such infectious wounds express a wide range of virulence factors promoting intercellular transmigration and host cell invasion complicating the treatment regimen. To address this need, a water‐dissolvable poly‐vinyl pyrrolidine (PVP), calcium peroxide (CPO) infused microneedle structure (denoted as PVP/CPO MN) for effective transdermal delivery of antimicrobial payload deep into the tissues is developed. Fluid exudate from the wound bed dissolves the PVP/CPO MN enabling the release of CPO deep into the infected wound bed. A slow catalytic decomposition of CPO results in the sustained release of reactive oxygen species (ROS) deep within the infected wound inhibiting the inter‐ and intracellular pathogens. Here, a systematic study of microneedle fabrication and sterilization after complete packaging is conducted to ensure scalability and safe applicability while maintaining mechanical and antibacterial properties. In vitro, antibacterial efficacy of the microneedles is validated against two common wound pathogens, Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus). Moreover, the PVP/CPO MN exhibited significant efficacy in eradicating both extracellular and intracellular bacterial populations within an in vivo porcine wound model. Additionally, the microneedle technology facilitated a faster wound healing, with ≈30% increase compared to control and a 15% improvement over conventional silver dressing.

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Effect of calcium peroxide particles as oxygen-releasing materials on cell growth and mechanical properties of scaffolds for tissue engineering

Cited by 7 publications

References 36 publications

Nanoengineered oxygen-releasing polymeric scaffold with sustained release of dexamethasone for bone regeneration

Nanoengineered oxygen-releasing polymeric scaffold with sustained release of dexamethasone for bone regeneration

Self‐healing polymers containing nanomaterials for biomedical engineering applications: A review

Microneedles for Enhanced Bacterial Pathogen Inactivation and Accelerated Wound Healing

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