Effect of calcium ions on the gelling and drug release characteristics of xanthan matrix tablets

Baumgartner, Stephan; Pavli, Matej; Kristl, Julijana

doi:10.1016/j.ejpb.2007.11.015

Cited by 46 publications

(36 citation statements)

References 27 publications

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“…This signifies that diffusion, polymer erosion and relaxation are the predominant mechanisms of drug release; this finding has also been reported in other literature sources 4,9,[10][11]30 . According to Baumgartner et al, (2008) the higher the ionic strength the more pronounced the contribution of Fickian diffusion 10 ; thus F1 obtained the lowest value because the formulation had the greatest calcium ion content.…”

supporting

confidence: 87%

“…This phenomenon occurs because in dilute solutions charge screening with calcium ions decreases the polymer's interaction with water; allowing the XG chains to assume ordered helical molecular conformations which occupy a smaller hydrodynamic volume leading to a decrease in viscosity 22 . Comparatively, at higher XG concentration, the interaction between the polymer molecules increases as salt content increases 3,10,22 . This effect outweighs the reduction in hydrodynamic volume of the molecules, and hence viscosity increases.…”

Section: Rheological Characterisation Of Xg Hydrogelsmentioning

confidence: 95%

“…Drug release from XG matrix tablets is also sensitive to the presence of ions in the release medium; this is of particular importance because the ionic strength of the GI fluid varies calcium ions within the matrix tablet increases, drug release also increases [10][11] . The effect of bivalent cations on the flow behaviour of XG solutions has been investigated in several studies 3,10,[12][13] .…”

Section: Xanthomonas Compestrismentioning

confidence: 99%

“…The effect of bivalent cations on the flow behaviour of XG solutions has been investigated in several studies 3,10,[12][13] . At increased ionic strength the ordered structure of XG predominates and this impacts the viscosity of the XG gel 12 .…”

Section: Xanthomonas Compestrismentioning

confidence: 99%

“…The drug release kinetics of the matrices is strongly associated with the structure of the polymer network in the gel layer and the arrangement of water molecules within it 10 .…”

Section: 'In Vitro' Drug Release Studiesmentioning

confidence: 99%

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Incorporation of calcium salts into xanthan gum matrices: hydration, erosion and drug release characteristics

Groves

Chaw

2014

Drug Development and Industrial Pharmacy

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Xanthan gum, a hydrophilic biopolymer with modified release properties, was used to produce directly compressed matrix tablets containing a model drug, Sodium paminosalicylate. Three formulations were prepared, each containing a different calcium dihydrate salt: Calcium Chloride, Calcium Sulfate or Dibasic Calcium Phosphate. The aim of the investigation was to relate the calcium ion content and solubility of the calcium salt to the in vitro drug release profile of the xanthan matrices. Tablet hydration, erosion and drug release were determined in distilled water using the BP paddle method. The data showed that the overall drug release was the greatest with addition of calcium Sulfate, followed by Calcium Chloride and dibasic Calcium Phosphate. The chloride salt formulation displayed the greatest percentage erosion due to rapid mass loss during the initial phase, followed by those with sulfate or phosphate salts. As xanthan gel viscosity increased and drug release was also found to be lower. It can be concluded that drug release is influenced by the solubility of the salt present in the formulation, since these parameters determine the viscosity and structure of the gel layer.

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supporting

confidence: 87%

Section: Rheological Characterisation Of Xg Hydrogelsmentioning

confidence: 95%

Section: Xanthomonas Compestrismentioning

confidence: 99%

Section: Xanthomonas Compestrismentioning

confidence: 99%

“…The drug release kinetics of the matrices is strongly associated with the structure of the polymer network in the gel layer and the arrangement of water molecules within it 10 .…”

Section: 'In Vitro' Drug Release Studiesmentioning

confidence: 99%

See 3 more Smart Citations

Incorporation of calcium salts into xanthan gum matrices: hydration, erosion and drug release characteristics

Groves

Chaw

2014

Drug Development and Industrial Pharmacy

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Xanthan gum: A versatile biopolymer for biomedical and technological applications

Petri

2015

J of Applied Polymer Sci

338

189

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Xanthan gum is an extracellular polymer produced mainly by the bacterium Xanthomonas campestris. Traditionally it plays an important role in industrial applications as thickener, emulsion stabilizer and it has been added to water-based drilling fluids due to its pseudoplastic behavior and thermal stability. The structural properties of xanthan in solution can be tuned by the temperature and ionic strength; under high ionic strength or low temperature, xanthan chains are arranged in helical conformation, whereas under low ionic strength or high temperature, xanthan chains are coiled. Xanthan high molecular weight favors the building up of physical and chemical networks, which have been used as carriers for drugs and proteins and as scaffolds for cells. In combination with other polymers xanthan has been applied as excipient in tablets or as supporting hydrogels for drug release applications, particularly due to its acid resistance. The large versatility of xanthan gum opens the possibility for the creation of new architectures and additional applications involving this fascinating polymer. AIMSThe purpose of this review is to report on the applications of xanthan gum in biomedical and technological products over the last ten years, but revisiting the background and the highlights of traditional applications as thickener. The in vivo biodegradability and biocompatibility of xanthan gum are fundamental characteristics that allow its use in biomedical applications. The ability to form networks and acid resistance make xanthan gum, as pure excipient or in combination with other polymers, very attractive as drug carriers. The recent combinations with inorganic particles open a range of new applications.

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Preparation and characterization of pH responsive poly(methacrylic acid‐acrylamide‐N‐hydroxyethyl acrylamide) hydrogels for drug delivery systems

Bal

Özkahraman

Özbaş

2015

J of Applied Polymer Sci

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In this study, pH responsive polymers composed of methacrylic acid, acrylamide, and N-hydroxyethyl acrylamide were synthesized by free radical polymerization technique. The characterization was done with Fourier transform infrared spectroscopy and scanning electron microscopy. The swelling and drug release behavior of the hydrogels was determined as a function of time at 378C in pH 2.1 and 7.4. The swelling and drug release studies showed that increased methacrylic acid amount caused a higher increase in swelling and drug release values at pH 7.4 than those at pH 2.1. In addition, the drug release data were applied to kinetic models such as zero order, first order, and Higuchi equations, and it fit well in the Higuchi model of the hydrogel. V C 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43226.

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Effect of calcium ions on the gelling and drug release characteristics of xanthan matrix tablets

Cited by 46 publications

References 27 publications

Incorporation of calcium salts into xanthan gum matrices: hydration, erosion and drug release characteristics

Incorporation of calcium salts into xanthan gum matrices: hydration, erosion and drug release characteristics

Xanthan gum: A versatile biopolymer for biomedical and technological applications

Preparation and characterization of pH responsive poly(methacrylic acid‐acrylamide‐N‐hydroxyethyl acrylamide) hydrogels for drug delivery systems

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