Effect of breast-feeding on the development of atopic dermatitis during the first 3 years of life—results from the GINI-birth cohort study

Laubereau, Birgit; Brockow, Inken; Zirngibl, Angelika; Koletzko, Sibylle; Gruebl, Armin; Berg, Andrea von; Filipiak-Pittroff, Birgit; Berdel, Dietrich; Bauer, Carl Peter; Reinhardt, D.; Heinrich, Joachim; Wichmann, H‐Erich

doi:10.1016/j.jpeds.2003.12.029

Cited by 140 publications

(81 citation statements)

References 29 publications

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“…O efeito do aleitamento materno é um exemplo clássico, em que a causalidade reversa pode levar a conclusões errôneas. O surgimento dos sintomas de eczema ou doença sibilante tende a prolongar a duração do aleitamento materno exclusivo, devido à crença geral no seu efeito protetor 24 . Tal relação pode levar à interpretação errônea de que a duração do aleitamento leva ao eczema ou à doença sibilante, quando, na verdade, são as doenças que prolongam a duração do aleitamento 25 .…”

Section: Resultsunclassified

“…[23][24][25] anos, com base em uma lista de nomes de participantes previamente projetada e sorteada a partir dos bancos de dados descritos acima. A seleção foi realizada com base na caracterização geoeconômica da cidade, que é constituída de quatro regiões geográficas definidas pela renda do chefe da família e classificadas como "pobre", "média-baixa", mé-dia-alta" e "rica" 14 .…”

Section: Introductionunclassified

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Atopy risk factors at birth and in adulthood

Ferraz¹,

Garcia²,

Bettiol³

et al. 2011

J Pediatr (Rio J)

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Objective: To study the association between atopy and variables such as weight, length, and socioeconomic level at birth and in young adulthood.Methods: A total of 2,063 subjects were investigated in a prospective birth cohort study of individuals born in Ribeirão Preto, Brazil, in 1978Brazil, in /1979, and examined at the age of 23-25 years. Skin prick tests (SPT) for eight common allergens in Brazil were performed. Subjects with a wheal reaction ≥ 3 mm to one or more of the eight allergens tested were considered to be atopic. We used the log-binomial model (generalized linear model) in order to assess the association between atopy and birth or adult variables. Results:The prevalence of positive SPT was 47.6%. Male gender was associated with an increased risk of atopy (relative risk [RR] = 1.18; 95% confidence interval [95%CI] 1.07-1.30). Low level of schooling was a protective factor against atopy, with a RR = 0.74; 95%CI 0.62-0.89. Living with a smoker in childhood was also associated with lower risk of atopy (RR = 0.87; 95%CI 0.79-0.96). Birth weight, length and order, maternal age, and intrauterine growth restriction were not associated with positive SPT. Conclusions:This study showed that male gender was associated with an increased risk of atopy. Low socioeconomic status, assessed by low level of schooling, was a protective factor against atopy. These data agree with the hygiene hypothesis.J Pediatr (Rio J). 2011;87(4):336-342: Allergens, allergy, risk factors, skin test. ResumoObjetivo: Estudar a associação entre atopia e variáveis como peso, comprimento e nível socioeconômico no nascimento e na idade adulta jovem. Métodos:Foram investigados 2.063 indivíduos em um estudo prospectivo de coorte de nascimento com indivíduos nascidos em Ribeirão Preto (SP), em 1978/1979, e examinados aos 23-25 anos de idade. Realizaram-se testes cutâneos de puntura (TCP) para oito alérgenos comuns no Brasil. Foram considerados atópicos os indivíduos que apresentaram reação papular ≥ 3 mm para um ou mais dos oito alérgenos testados. A fim de avaliar a associação entre atopia e variáveis no nascimento e na idade adulta, utilizamos o modelo log-binomial (modelo linear generalizado).Resultados: A prevalência de TCP positivo foi de 47,6%. O gênero masculino esteve associado a aumento do risco de atopia [risco relativo (RR) = 1,18; intervalo de confiança de 95% (IC95%) 1,07-1,30]. O baixo nível de escolaridade foi um fator de proteção contra atopia, com um RR = 0,74; IC95% 0,62-0,89. A convivência com um fumante na infân-cia também esteve associada a um menor risco de atopia (RR = 0,87; IC95% 0,79-0,96). Peso e comprimento ao nascer, ordem de nascimento, idade materna e restrição de crescimento intrauterino não estiveram associados a TPC positivo. Conclusões:Este estudo demonstrou que o gênero masculino esteve associado a um aumento do risco de atopia. O baixo nível socioeconômico, estabelecido pelo baixo nível de escolaridade, foi um fator de proteção contra a atopia. Esses dados estão de acordo com a teoria da higiene...

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Section: Resultsunclassified

Section: Introductionunclassified

Atopy risk factors at birth and in adulthood

Ferraz¹,

Garcia²,

Bettiol³

et al. 2011

J Pediatr (Rio J)

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“…Efek protektif ASI terhadap DA juga ditemukan pada beberapa penelitian lainnya. 26,[37][38][39][40][41][42][43][44] Di lain pihak, beberapa studi melaporkan bahwa ASI tidak memengaruhi risiko terjadinya DA 45,46 atau bahkan berkaitan dengan meningkatnya risiko DA. 15,[47][48][49] Kami belum berhasil membuktikan peran pemberian ASI eksklusif untuk mencegah kejadian DA pada anak berusia 7-24 bulan.…”

Section: Pembahasanunclassified

Manfaat Pemberian ASI Eksklusif dalam Pencegahan Kejadian Dermatitis Atopi pada Anak

Halim

Munasir

Rohsiswatmo

2016

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D ermatitis atopi (DA) adalah kelainan inflamasi kronis pada kulit yang sering terjadi pada anak. Masalah ini menjadi semakin penting karena prevalens yang meningkat di seluruh dunia.1-5 Prevalens DA pada anak meningkat 2-3 kali selama tiga dekade terakhir terutama di negara maju, seperti di Amerika Serikat, Jepang, dan negara-negara di Eropa Barat (10%-20%).3-9 Prevalens DA yang lebih rendah terdapat pada negara berkembang di Eropa Timur, Afrika, dan Asia Tengah.3,5,10 Sebuah studi kohort di Jakarta pada tahun 2010 dilaporkan prevalens DA 16,4% pada anak berusia 0-6 bulan. 11Sekitar 80% anak dengan DA akan mengalami asma dan rinitis alergi (allergic march) di kemudian hari.

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“…Besides a number of well-known short-term effects for mothers and infants, breastfeeding has benefi cial effects even for long-term health. Among these, decreased incidence of atopic dermatitis (Laubereau et al 2004), respiratory infections (Bachrach et al 2003) and asthma (Haby et al 2001) were reported, as well as a lower risk of type 1 diabetes (Dahlquist 1995), type 2 diabetes (Pettitt et al 1997, Young et al 2002, and elevated blood pressure (Owen et al 2003).…”

Section: Human _ Ontogenetic S G ü N T E R D ö R N E R E L K E R O mentioning

confidence: 99%

Maternal deprivation and overnutrition in early postnatal life and their primary prevention: Historical reminiscence of an “ecologic experiment” in Germany

2008

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During critical developmental periods in early life, altered environmental conditions can lead to pre-and early postnatally acquired, life-long malfunctions and subsequent diseases (Perinatal Programming). Avoiding unfavourable conditions during early development may thus open possibilities of primary prevention.At the beginning of the 21 st century, demographic aging and increasing overweight prevalences are two major problems nearly world-wide. Interestingly, during the second half of the last century, an outstanding "ecologic experiment" has taken place in central Europe, where Germany was divided for four decades into two parts with differing political, economic, social and medical systems, and different approaches towards prevention, especially in early life. Two examples of preventive measures introduced and realized in East Germany and East Berlin until the German reunifi cation were intense breastfeeding promotion and the so-called "Baby-Year", which meant that a mother could stay at home receiving her full salaries for one year after giving birth. Possible outcomes of these measures of primary prevention with effect on demographic aging and overweight risk in the people will be outlined in this essay.

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Effect of breast-feeding on the development of atopic dermatitis during the first 3 years of life—results from the GINI-birth cohort study

Cited by 140 publications

References 29 publications

Atopy risk factors at birth and in adulthood

Atopy risk factors at birth and in adulthood

Manfaat Pemberian ASI Eksklusif dalam Pencegahan Kejadian Dermatitis Atopi pada Anak

Maternal deprivation and overnutrition in early postnatal life and their primary prevention: Historical reminiscence of an “ecologic experiment” in Germany

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