Maternal deprivation and overnutrition in early postnatal life and their primary prevention: Historical reminiscence of an “ecologic experiment” in Germany

Dörner, G; Rodekamp, Elke; Plagemann, Andreas

doi:10.1002/huon.200800008

Cited by 13 publications

(8 citation statements)

References 42 publications

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“…have adopted an important measure for early-life prevention of NCDs. As a successful example, the intense promotion of breastfeeding initiated by East Germany yielded a lower prevalence of obesity in young individuals compared to that in the corresponding West Berlin population, which was not introduced to intense breastfeeding (Dörner, Rodekamp, & Plagemann, 2008).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Prenatal inflammation exposure-programmed cardiovascular diseases and potential prevention

Deng

Song

Nie

et al. 2018

Pharmacology & Therapeutics

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In recent years, the rapid development of medical and pharmacological interventions has led to a steady decline in certain noncommunicable chronic diseases (NCDs), such as cancer. However, the overall incidence of cardiovascular diseases (CVDs) has not seemed to decline. CVDs have become even more prevalent in many countries and represent a global health threat and financial burden. An increasing number of epidemiological and experimental studies have demonstrated that maternal insults not only can result in birth defects but also can cause developmental functional defects that contribute to adult NCDs. In the current review, we provide an overview of evidence from both epidemiological investigations and experimental animal studies supporting the concept of developmental reprogramming of adult CVDs in offspring that have experienced prenatal inflammation exposure (PIE) during fetal development (PIE-programmed CVDs), a disease-causing event that has not been effectively controlled. This review describes the epidemiological observations, data from animal models, and related mechanisms for the pathogenesis of PIE-programmed CVDs. In addition, the potential therapeutic interventions of PIE-programmed CVDs are discussed. Finally, we also deliberate the need for future mechanistic studies and biomarker screenings in this important field, which creates a great opportunity to combat the global increase in CVDs by managing the adverse effects of inflammation for prepregnant and pregnant individuals who are at risk for PIE-programmed CVDs.

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Section: Accepted Manuscriptmentioning

confidence: 99%

Prenatal inflammation exposure-programmed cardiovascular diseases and potential prevention

Deng

Song

Nie

et al. 2018

Pharmacology & Therapeutics

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“…Conceptually, Dörner also contributed by introducing the term 'programming' (die Programmierung) in the sense that it is now, rightly or wrongly, used and he argued for the notion of 'functional teratogenesis' to describe the observed phenomena. 24,26 Along the same lines and at the same time, the diabetologist Norbert Freinkel developed the hypothesis of 'fuel-mediated teratogenesis' to explain how the metabolic state of the mother could influence her offspring as well as intergenerational transmission of risk of diabetes. In his 1980 Banting lecture, he stated that 'developing fetal structures may be exquisitely attuned to fine alterations in maternal fuel economyy It is suggested that concepts of teratogenesis should be expanded to include alterations occurring subsequent to organogenesis during the differentiation and proliferation of fetal cells.…”

Section: The Emergence Of the Dohad Conceptmentioning

confidence: 99%

A conceptual framework for the developmental origins of health and disease

Gluckman

Hanson

Buklijaš

2009

J Dev Orig Health Dis

436

266

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In the last decades, the developmental origins of health and disease (DOHaD) have emerged as a vigorous field combining experimental, clinical, epidemiological and public health research. Its goal is to understand how events in early life shape later morbidity risk, especially of non-communicable chronic diseases. As these diseases become the major cause of morbidity and mortality worldwide, research arising from DOHaD is likely to gain significance to public health and economic development. But action may be hindered by the lack of a firm mechanistic explanation and of a conceptual basis, especially regarding the evolutionary significance of the DOHaD phenomenon. In this article, we provide a succinct historical review of the research into the relationship between development and later disease, consider the evolutionary and developmental significance and discuss the underlying mechanisms of the DOHaD phenomenon. DOHaD should be viewed as a part of a broader biological mechanism of plasticity by which organisms, in response to cues such as nutrition or hormones, adapt their phenotype to environment. These responses may be divided into those for immediate benefit and those aimed at prediction of a future environment: disease occurs in the mismatch between predicted and realized future. The likely mechanisms that enable plasticity involve epigenetic processes, affecting the expression of genes associated with regulatory pathways. There is now evidence that epigenetic marks may be inherited and so contribute to non-genomic heritable disease risk. We end by discussing the global significance of the DOHaD phenomenon and its potential applications for public health purposes.

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“…Although research on the relation between early weight gain and later overweight risk has only recently achieved broad attention, fi rst studies on this subject date back to the 1970s. Already in 1977, D ö rner et al reported that excessive weight gain during the fi rst months of life was a decisive risk factor for later overweight ( [7,9,10] ; for review see [8] ). During recent years, the body of data showing that increased early weight gain is an independent risk factor for later overweight has been increasing continuously.…”

Section: Discussionmentioning

confidence: 99%

Rapid neonatal weight gain increases risk of childhood overweight in offspring of diabetic mothers

Plagemann¹,

Harder²,

Rodekamp³

et al. 2012

Journal of Perinatal Medicine

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Aim: Increased neonatal weight gain has been suggested as risk factor for later overweight. Offspring of diabetic mothers (ODM) have a long-term increased overweight risk. However, the role of early postnatal weight gain for later overweight has not been addressed so far in ODM. We investigated whether increased weight gain during the fi rst 4 months is related to later overweight in ODM. Methods: Determinants of childhood overweight and neonatal weight gain were analyzed in 152 ODM from the Kaulsdorf Cohort Study by MANOVA and regression analyses. Results: Independent of birth weight, weight gain during the fi rst 4 months was positively related to childhood relative body weight (P = 0.001). Each 100 g-increase in weight during this period increased overweight risk by 65 % (95 % CI: 10 -247 % ). ODM with rapid early weight gain had a more than six-fold increased risk of later overweight (OR: 6.77; 95 % CI: 1.36 -33.6). Early neonatal intake of breast milk from metabolically healthy mothers protected from rapid early weight gain (P = 0.03). Conclusions: Increased weight gain during the fi rst 4 months of life is a strong, independent risk factor for childhood overweight in ODM. Preventing nutritionally-induced rapid early weight gain in ODM might be a promising strategy to lower their long-term overweight risk.

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Maternal deprivation and overnutrition in early postnatal life and their primary prevention: Historical reminiscence of an “ecologic experiment” in Germany

Cited by 13 publications

References 42 publications

Prenatal inflammation exposure-programmed cardiovascular diseases and potential prevention

Prenatal inflammation exposure-programmed cardiovascular diseases and potential prevention

A conceptual framework for the developmental origins of health and disease

Rapid neonatal weight gain increases risk of childhood overweight in offspring of diabetic mothers

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