Effect of Brahmi vati and Sarpagandha Ghana vati in management of essential hypertension – A randomized, double blind, clinical study

Mishra, Dhanpat; Tubaki, Basavaraj R.

doi:10.1016/j.jaim.2017.04.001

Cited by 13 publications

(11 citation statements)

References 38 publications

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“…7 In a clinical study conducted in India, Brahmi was found to decrease SBP, DBP and MAP significantly at 4 weeks of treatment, similar to the findings in this study. 8 Shunthi, the processed dry ginger, has shown promising results individually in various studies as an antihypertensive agent. In a study conducted in China, daily consumption of ginger was associated with decreased risk of hypertension in adults (OR = 0.92, CI: 0.87-0.99).…”

Section: Discussionmentioning

confidence: 99%

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The effect of a polyherbal oral formulation in the management of essential hypertension: an open label, pilot clinical study

Sane

Dawkhar

Ambulkar

et al. 2018

Int J Basic Clin Pharmacol

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Background: Effective control of blood pressure in patients with hypertension decreases cardiovascular mortality. However, many hypertensives are unresponsive to standard antihypertensive treatment. Research has found anti-hypertensive potential in the Ayurvedic drugs Brahmi (Bacopa monnieri) and Shunthi (Zingiber officinale). Hence, a pilot study was conducted to evaluate the efficacy and safety of Capsule Artyl (the oral formulation of Brahmi and Shunthi) as a treatment option in hypertensive subjects.Methods: There were 30 hypertensive subjects attending out-patient departments of clinics in Maharashtra, India were enrolled in this four-week, open label, single arm study. All subjects received capsule Artyl (500mg) twice a day orally daily. The mean systolic (SBP) and diastolic blood pressure (DBP) on days 1 and 28 of the study were compared along with the mean arterial pressure (MAP).Results: The mean SBP was significantly lesser on day 28 (141.86±12.54mm Hg) as compared to the mean SBP recorded on day 1 (155.48±19.37mm Hg) (p<0.001). The mean DBP on day 28 (89.66±6.8mm Hg) was lesser than that on day 1 (90.34±7.44mm Hg) but this difference was not statistically significant (p>0.05). There was a significant decrease in the mean value of MAP on day 28 (107.06±7.03mm Hg) as compared to that on day 1 (112.06±10.75mm Hg) (p<0.01).Conclusions: Capsule Artyl significantly decreased the BP in hypertensive patients, without any adverse effects. Controlled trials are needed to confirm the positive outcome of this promising herbal formulation in hypertensive patients.

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Section: Discussionmentioning

confidence: 99%

“…6 There have been very few studies which have tried to evaluate the effect of Brahmi as an antihypertensive agent. 7,8 Shunthi, the processed dry ginger is a popular herb used extensively in the Indian subcontinent as a food additive. The beneficial effect of Shunthi in cardiovascular disease has been known for long.…”

mentioning

confidence: 99%

The effect of a polyherbal oral formulation in the management of essential hypertension: an open label, pilot clinical study

Sane

Dawkhar

Ambulkar

et al. 2018

Int J Basic Clin Pharmacol

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“…Sun salutation helps warm up the body (12). Hrudaydhara is done to stimulate the chambers of the heart to strengthen the cardiovascular system, with brahmi gritham to improve circulation (13) and ksheerabala 101 to strengthen heart function (14). MSRT is a meditation technique, practiced to calm the mind and reduce stress level by using of mind power and creating certain patterns of vibration associated with resonance (15).…”

Section: Recruitment Of Patientmentioning

confidence: 99%

A case study on effect of integrative medicine with combination of hrudaydhara (heart stimulation) and yoga therapy on ejection fraction of patient with history of hypertension

Tripathi¹,

Azuma²

2021

IMCR

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Today, cardiovascular disease has become a global health issue owing to high-stress in personal and professional environments and adverse lifestyle changes with neglected diet and decreased physical activity. Ayurveda and Yoga aim not only to treat diseases but to also reinforce measures to promote health and well-being. Holistic approaches in these two sciences can be used in an effective way to improve cardiovascular health. A blend of Yoga practices and Ayurveda therapy is quintessentially useful for both the mind and body. Sun Salutation and Mind Sound Resonance Technique (MSRT) meditation work on calming the mind and allow the body to transition into a high energy state for moderate exercise. This is followed ultimately by Hrudaydhara of Ayurveda which focuses on relaxing the intercostal and cardiac muscle which in turn reduces chest discomfort of the patient and eventually improves the ejection fraction of the heart. This shows evidence that integrating yoga and ayurvedic practices with conventional medicine can be a collaborative approach while managing cardiovascular ailments.

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“…calamus has also been clinically investigated as a monotherapy as well as in combination with other medicinal herbs in healthy subjects and sufferers of various metabolic and neurological ailments. Most clinical research has looked at the A. calamus effect on obesity, depression, neuroprotection, and cardiovascular disease [178][179][180][181][182][183][184][185][186][187][188][189][190][191]. The data obtained so far can be found in Table 5.…”

Section: Clinical Reportsmentioning

confidence: 99%

Role of Vacha (Acorus calamus Linn.) in Neurological and Metabolic Disorders: Evidence from Ethnopharmacology, Phytochemistry, Pharmacology and Clinical Study

Sharma

Gautam

et al. 2020

JCM

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Vacha (Acorus calamus Linn. (Acoraceae)) is a traditional Indian medicinal herb, which is practiced to treat a wide range of health ailments, including neurological, gastrointestinal, respiratory, metabolic, kidney, and liver disorders. The purpose of this paper is to provide a comprehensive up-to-date report on its ethnomedicinal use, phytochemistry, and pharmacotherapeutic potential, while identifying potential areas for further research. To date, 145 constituents have been isolated from this herb and identified, including phenylpropanoids, sesquiterpenoids, and monoterpenes. Compelling evidence is suggestive of the biopotential of its various extracts and active constituents in several metabolic and neurological disorders, such as anticonvulsant, antidepressant, antihypertensive, anti-inflammatory, immunomodulatory, neuroprotective, cardioprotective, and anti-obesity effects. The present extensive literature survey is expected to provide insights into the involvement of several signaling pathways and oxidative mechanisms that can mitigate oxidative stress, and other indirect mechanisms modulated by active biomolecules of A. calamus to improve neurological and metabolic disorders.

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Effect of Brahmi vati and Sarpagandha Ghana vati in management of essential hypertension – A randomized, double blind, clinical study

Abstract: Clinical efficacy of Sarpagandha Ghana vati and Brahmi vati on EHTN showed that both were effective, safe and comparable. Both were comprehensively effective in management of EHTN.

Cited by 13 publications

References 38 publications

The effect of a polyherbal oral formulation in the management of essential hypertension: an open label, pilot clinical study

The effect of a polyherbal oral formulation in the management of essential hypertension: an open label, pilot clinical study

A case study on effect of integrative medicine with combination of hrudaydhara (heart stimulation) and yoga therapy on ejection fraction of patient with history of hypertension

Role of Vacha (Acorus calamus Linn.) in Neurological and Metabolic Disorders: Evidence from Ethnopharmacology, Phytochemistry, Pharmacology and Clinical Study

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