Effect of body vitamin K level on collagen metabolism in the skin

Sharaev, P. N.; Bogdanov, N. G.; Yamaldinov, R. N.

doi:10.1007/bf00802990

Cited by 4 publications

(2 citation statements)

References 3 publications

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“…(1976) showed that in rats with avitaminosis K, the collagen content in the skin was reduced and the rate of hydrolysis of collagen increased. [21] Hence, the healing effect of topical vitK could be attributed to its effect on collagen stability. Angiogenesis, which is integral to successful wound repair, refers to the in growth of new vessels into a wound from the surrounding tissue.…”

Section: Discussionmentioning

confidence: 99%

Topical vitamin K ₁ promotes repair of full thickness wound in rat

et al. 2014

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Objectives:Application of vitamin K to the skin has been used for suppression of pigmentation and resolution of bruising. However, in rats, no study was reported on its effect regarding wound healing. Thus, the present study was designed to examine the healing effects of creams prepared from vitamin K1 on full-thickness wound in rats.Materials and Methods:For inducing full-thickness wound in rats, the excisional wound model was used. Five groups consisting of 8 rats each were used. Vitamin K cream (1% and 2%, w/w) was prepared in eucerin base and applied on the wound once a day until complete healing had occurred. Healing was defined by decreased wound margin (wound contraction), re-epithelialization, tensile strength and hydroxyproline content. Histopathological examination was also done.Results:The effects produced by the topical vitamin K showed significant (P < 0.01) healing when compared with control group in parameters such as wound contraction, epithelialization period, hydroxyproline content and tensile strength. Histopathological studies also showed improvement with vitamin K.Conclusions:Topical vitamin K demonstrates wound healing potential in full-thickness wound model.

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Section: Discussionmentioning

confidence: 99%

Topical vitamin K ₁ promotes repair of full thickness wound in rat

et al. 2014

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“…The specimens were cut free of soft tissues, washed with physiological saline, and homogenized [5]. Parameters of collagen metabolism were assessed as described previously [3].…”

Section: Methodsmentioning

confidence: 99%