Metabolism of collagen in experimental osteomyelitis

Strelkov, N S; Sharaev, P. N.; Naumova, N. G.; Maksimov, P. N.

doi:10.1007/bf02433299

Cited by 3 publications

(1 citation statement)

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“…However, activated PMN synthesize highly reactive oxidants, like hydrogen peroxide, superoxide anion radical and hypochlorous acid, which may damage the bone tissue and cartilage [ 2 , 3 ]. These oxidants were shown to increase the catabolic rate of bone matrix proteins, induce osteoclastogenesis and bone resorption, and suppress differentiation of osteoblastic and marrow stromal cells [ 4 – 9 ]. In biological systems, the concentration of oxidants is normally low and under strict control of enzymatic and nonenzymatic antioxidants.…”

Section: Introductionmentioning

confidence: 99%

Sequential Analysis of Oxidative Stress Markers and Vitamin C Status in Acute Bacterial Osteomyelitis

Grbić¹,

Mirić²,

Kisic³

et al. 2014

Mediators of Inflammation

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In bacterial bone infections, excessively formed oxidants may result in local and systemic oxidative stress. Vitamin C is the major extracellular nonenzymatic antioxidant, also implicated in bone cells metabolism and viability. The physiological functions of vitamin C largely depend on its redox status. We sequentially assessed oxidative stress markers, hydroperoxides and malondialdehyde (MDA), total antioxidant activity (AOA), total vitamin C, ascorbic acid (Asc), and oxidized/reduced vitamin C ratio in 137 patients with acute osteomyelitis (OM). Compared to 52 healthy controls, in OM group baseline serum hydroperoxides, MDA and oxidized/reduced vitamin C ratio were higher whilst Asc and AOA were lower (P < 0.05, resp.). On the other side, total vitamin C levels in patients and controls were similar (P > 0.05), thereby suggesting a relative rather than absolute vitamin C deficiency in OM. During the follow-up, oxidative stress markers, AOA, and oxidizedreduced vitamin C ratio were gradually returned to normal, while there was no apparent change of total vitamin C concentrations. Persistently high values of oxidized/reduced vitamin C ratio and serum MDA were found in subacute OM. In conclusion, acute OM was associated with enhanced systemic oxidative stress and the shift of vitamin C redox status towards oxidized forms.

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Section: Introductionmentioning

confidence: 99%

Sequential Analysis of Oxidative Stress Markers and Vitamin C Status in Acute Bacterial Osteomyelitis

Grbić¹,

Mirić²,

Kisic³

et al. 2014

Mediators of Inflammation

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Effects of hydra peptide morphogen and its analogue and fragments on DNA synthesis in tracheal epithelium and smooth muscle cells in newborn albino rats

2000

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Hydra peptide morphogen, its Arg(7) analogue, and 6C, 3C, and 5N fragments were injected intraperitoneally in a dose 10(-7) mol/kg to newborn rats from the 2nd to 6th day of life. Autoradiography with (3)H-thymidine showed that hydra peptide morphogen and its 6C fragment stimulated DNA synthesis in tracheal epitheliocytes, but inhibited this process in smooth muscle cells. 5N fragment inhibited DNA synthesis in both tissues, while 3C and Arg(7) were ineffective.

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Experimental Simulation of Traumatic Osteomyelitis in Rats

et al. 2016

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Metabolism of collagen in experimental osteomyelitis

Abstract: Serum and local bone indexes of collagen catabolism were considerably increased in rabbit pups with acute stage of tibial osteomyelitis. Chronic stage of osteomyelitis was characterized by an elevated content of hydroxyproline bound to low-molecular-weight collagen fragments.

Cited by 3 publications

References 3 publications

Sequential Analysis of Oxidative Stress Markers and Vitamin C Status in Acute Bacterial Osteomyelitis

Sequential Analysis of Oxidative Stress Markers and Vitamin C Status in Acute Bacterial Osteomyelitis

Effects of hydra peptide morphogen and its analogue and fragments on DNA synthesis in tracheal epithelium and smooth muscle cells in newborn albino rats

Experimental Simulation of Traumatic Osteomyelitis in Rats

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