Effects of hydra peptide morphogen and its analogue and fragments on DNA synthesis in tracheal epithelium and smooth muscle cells in newborn albino rats

Abstract

Hydra peptide morphogen, its Arg(7) analogue, and 6C, 3C, and 5N fragments were injected intraperitoneally in a dose 10(-7) mol/kg to newborn rats from the 2nd to 6th day of life. Autoradiography with (3)H-thymidine showed that hydra peptide morphogen and its 6C fragment stimulated DNA synthesis in tracheal epitheliocytes, but inhibited this process in smooth muscle cells. 5N fragment inhibited DNA synthesis in both tissues, while 3C and Arg(7) were ineffective.