Topical vitamin K ₁ promotes repair of full thickness wound in rat

Abstract

Objectives:Application of vitamin K to the skin has been used for suppression of pigmentation and resolution of bruising. However, in rats, no study was reported on its effect regarding wound healing. Thus, the present study was designed to examine the healing effects of creams prepared from vitamin K1 on full-thickness wound in rats.Materials and Methods:For inducing full-thickness wound in rats, the excisional wound model was used. Five groups consisting of 8 rats each were used. Vitamin K cream (1% and 2%, w/w) was prepared in eucerin base and applied on the wound once a day until complete healing had occurred. Healing was defined by decreased wound margin (wound contraction), re-epithelialization, tensile strength and hydroxyproline content. Histopathological examination was also done.Results:The effects produced by the topical vitamin K showed significant (P < 0.01) healing when compared with control group in parameters such as wound contraction, epithelialization period, hydroxyproline content and tensile strength. Histopathological studies also showed improvement with vitamin K.Conclusions:Topical vitamin K demonstrates wound healing potential in full-thickness wound model.

Prodrugs for Skin Delivery of Menahydroquinone-4, an Active Form of Vitamin K2(20), Could Overcome the Photoinstability and Phototoxicity of Vitamin K2(20)

“…Skin application of vitamin K exhibits several beneficial effects such as suppressing pigmentation and resolving bruising [2,3,4], prophylactically limiting the occurrence of acneiform side effects in patients receiving the monoclonal antibody cetuximab [5,6,7,8], and promoting wound healing [9].…”

Effect of phylloquinone on indomethacin‐induced gastric ulceration in rats: Role of SIRT‐1

“…Phylloquinone (vitamin k1) is an essential macronutrient having anti‐inflammatory and antioxidant properties which was proved in previous studies 20,23,24 . The main target of our study is exploring the potential effects of phylloquinone against indomethacin‐induced gastric ulceration and studying the involved mechanisms.…”

“…Also, it inhibits inflammation by hindering NF‐κB and inducible nitric oxide synthase (iNOS) which are master regulators of the inflammatory process 21 Moreover, it effectively decreased hyperglycaemia in streptozotocin induced‐diabetes in rats 22 . Studies also showed that rats receiving phylloquinone show rapid healing of left colon 23 and that topical application of phylloquinone improves wound healing in rats 24 …”

Wound healing effects of topical Vitamin K: A randomized controlled trial

“…At the previous work, we reported that topical Vitamin K may promote wound healing activity, probably due to its ability to significantly increase the rate of wound contraction, enhancement of epithelialization period, formation of fibroblasts cells, collagen fibers and blood vessels, and increment in hydroxyproline content in experimental models. [15] In this regard, Sharaev et al . revealed that in rats with secondary avitaminosis K, the collagen content in the skin was reduced and the content of free hydroxyproline increased.…”

“…The doses of phenytoin and Vitamin K for topical administration were selected based on our previous report. [15]…”