Wound healing effects of topical Vitamin K: A randomized controlled trial

Abstract

BACKGROUND: The incidence of acute and chronic wounds has rapidly increased which treatment remains as health problem. Previously, we reported the healing effect of Vitamin K in experimental animal models. The aim of this study was to investigate the effects of topical Vitamin K on skin wound healing process in patients. MATERIALS AND METHODS: Sixty-three patients with indication for high-frequency electrocautery were enrolled in this randomized controlled trial. The patients were divided randomly into three groups. All the patients underwent high-frequency electrocautery treatment. Then, the patients in the A group received 1% Vitamin K cream, the patients in the B group received 1% phenytoin cream. Furthermore, the patients in the control group received Eucerin. The wound status (width and the time of recovery) and complications in the three groups were evaluated 2 weeks after procedure by a dermatologist. RESULTS: The effects produced by the topical Vitamin K showed a significant ( P < 0.05) healing when compared with Eucerin group in parameters such as wound contraction and time to full recovery. Moreover, the healing time did not differ between phenytoin and Vitamin K groups ( P = 0.16). CONCLUSION: A randomized, controlled trial suggests that topical application of Vitamin K significantly reduces healing time in patients.

Evidence-Based Nutritional Interventions in Wound Care

“…Among the 36 included studies, there are three studies with a total of 114 patients receiving treatment for burn wounds, seven studies with 451 patients receiving treatment for pressure ulcer wounds, four studies with 170 patients receiving treatment for diabetic ulcer wounds, seven studies with 421 patients receiving treatment for venous ulcer wounds, one study with 27 patients receiving treatment for digital ulcers, nine studies with 864 patients receiving treatment for skin incision wounds, four studies with 262 patients receiving treatment for hypertrophic scars, and one study with 30 patients receiving treatment for sinonasal wounds (Table 1). 1–36 A summary of effectiveness is provided in Table 2, and a histogram overview of outcomes is provided in Table 3.…”

“…The authors reported no significant differences in outcomes or time to definitive wound closure (10.6 days versus 12.4 days; p = 0.6) in patients receiving topical vitamin K compared with the placebo group. 28…”

Carboxymethyl Chitosan Hydrogels for Effective Wound Healing—An Animal Study

“…If the wound healing process proceeds properly, the tissue returns to its pre-injury state. However, in some cases, the process may result in chronic wounds that can be accompanied by infections [ 1 , 2 ]. It is assumed that in developed countries 1–2% of the population will experience a chronic wound in their lifetime, and these numbers are gradually increasing.…”

Effect of White Tea (Camellia sinensis) Extract on Skin Wound Healing Process in Rats

“…Therefore, wounds by causing a disturbance in skin anatomy and function may lead to complications such as infection and even shock 3 , 4 . Because of the importance of healthy skin, wounds prevalence and the costs of skin wound treatment, it is essential to find a low-cost and effective treatment for skin wounds 2 , 5 , 6 .…”

“…Overproduction of ROS is cytotoxic and delays wound healing process. Therefore, one way to improve wound healing is reducing ROS 5 .…”