Carboxymethyl Chitosan Hydrogels for Effective Wound Healing—An Animal Study

Kłosiński, Karol Kamil; Wach, Radosław Aleksander; Kruczkowska, Weronika; Duda, Łukasz; Kołat, Damian; Kałuzińska-Kołat, Żaneta; Arkuszewski, Piotr Tomasz; Pasieka, Zbigniew Włodzimierz

doi:10.3390/jfb14090473

Cited by 2 publications

(3 citation statements)

References 62 publications

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“…The positive effects of chitosan-based formulations in wound healing have been confirmed by numerous studies [6,[145][146][147]149]. Because the current therapeutic approaches for neurological diseases sometimes yield unsatisfactory outcomes, smart chitosan hydrogels are investigated for their potential to solve problems such as limited accessibility or high levels of risk and discomfort during therapeutic procedures [161,162].…”

Section: Discussionmentioning

confidence: 94%

“…Chitosan-based hydrogels have shown beneficial effects on wound treatment in many studies [6,[145][146][147][148][149]. One study aimed to design novel 3D bioactive and biomimetic…”

Section: Wound Healingmentioning

confidence: 99%

“…Chitosan-based hydrogels have shown beneficial effects on wound treatment in many studies [6,[145][146][147][148][149]. One study aimed to design novel 3D bioactive and biomimetic smart hydrogels with oxidized hyaluronic acid (oxHA) and oxidized chitosan (oxCS) as cross-linkers.…”

Section: Wound Healingmentioning

confidence: 99%

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Biomedical Trends in Stimuli-Responsive Hydrogels with Emphasis on Chitosan-Based Formulations

Kruczkowska,

Gałęziewska,

Grabowska

et al. 2024

Gels

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Biomedicine is constantly evolving to ensure a significant and positive impact on healthcare, which has resulted in innovative and distinct requisites such as hydrogels. Chitosan-based formulations stand out for their versatile utilization in drug encapsulation, transport, and controlled release, which is complemented by their biocompatibility, biodegradability, and non-immunogenic nature. Stimuli-responsive hydrogels, also known as smart hydrogels, have strictly regulated release patterns since they respond and adapt based on various external stimuli. Moreover, they can imitate the intrinsic tissues’ mechanical, biological, and physicochemical properties. These characteristics allow stimuli-responsive hydrogels to provide cutting-edge, effective, and safe treatment. Constant progress in the field necessitates an up-to-date summary of current trends and breakthroughs in the biomedical application of stimuli-responsive chitosan-based hydrogels, which was the aim of this review. General data about hydrogels sensitive to ions, pH, redox potential, light, electric field, temperature, and magnetic field are recapitulated. Additionally, formulations responsive to multiple stimuli are mentioned. Focusing on chitosan-based smart hydrogels, their multifaceted utilization was thoroughly described. The vast application spectrum encompasses neurological disorders, tumors, wound healing, and dermal infections. Available data on smart chitosan hydrogels strongly support the idea that current approaches and developing novel solutions are worth improving. The present paper constitutes a valuable resource for researchers and practitioners in the currently evolving field.

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Section: Discussionmentioning

confidence: 94%

“…Chitosan-based hydrogels have shown beneficial effects on wound treatment in many studies [6,[145][146][147][148][149]. One study aimed to design novel 3D bioactive and biomimetic…”

Section: Wound Healingmentioning

confidence: 99%

See 1 more Smart Citation

Biomedical Trends in Stimuli-Responsive Hydrogels with Emphasis on Chitosan-Based Formulations

Kruczkowska,

Gałęziewska,

Grabowska

et al. 2024

Gels

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Medical Applications and Cellular Mechanisms of Action of Carboxymethyl Chitosan Hydrogels

Kruczkowska,

Kłosiński,

Grabowska

et al. 2024

Molecules

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Carboxymethyl chitosan (CMCS) hydrogels have been investigated in biomedical research because of their versatile properties that make them suitable for various medical applications. Key properties that are especially valuable for biomedical use include biocompatibility, tailored solid-like mechanical characteristics, biodegradability, antibacterial activity, moisture retention, and pH stimuli-sensitive swelling. These features offer advantages such as enhanced healing, promotion of granulation tissue formation, and facilitation of neutrophil migration. As a result, CMCS hydrogels are favorable materials for applications in biopharmaceuticals, drug delivery systems, wound healing, tissue engineering, and more. Understanding the interactions between CMCS hydrogels and biological systems, with a focus on their influence on cellular behavior, is crucial for leveraging their versatility. Because of the constantly growing interest in chitosan and its derivative hydrogels in biomedical research and applications, the present review aims to provide updated insights into the potential medical applications of CMCS based on recent findings. Additionally, we comprehensively elucidated the cellular mechanisms underlying the actions of these hydrogels in medical settings. In summary, this paper recapitulates valuable data gathered from the current literature, offering perspectives for further development and utilization of carboxymethyl hydrogels in various medical contexts.

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Carboxymethyl Chitosan Hydrogels for Effective Wound Healing—An Animal Study

Cited by 2 publications

References 62 publications

Biomedical Trends in Stimuli-Responsive Hydrogels with Emphasis on Chitosan-Based Formulations

Biomedical Trends in Stimuli-Responsive Hydrogels with Emphasis on Chitosan-Based Formulations

Medical Applications and Cellular Mechanisms of Action of Carboxymethyl Chitosan Hydrogels

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