Effect of aqueous extracts of several kinds of herbs on human platelet aggregation and expression of P-selectin in vitro

Yan, Linggeng; Ruan, Junshan; Zhang, Lei; Fan, Fangtian; Zhang, Feng; Wang, Aiyun; Zheng, Shizhong; Zeng, Li; Li, Wenlin; Lu, Yin

doi:10.1007/s11655-013-1540-5

Cited by 13 publications

(4 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…San-qi (Radix Notoginseng) was reported to work together with other herbs to control the inflammation and promote bone healing (Peng et al, 2010). Finally, Ji-xue-teng (Caulis Spatholobi) was found to ameliorate hepcidin-overexpression (Guan et al, 2013) and has potent anti-platelet properties (Yan et al, 2015). In summary, these herbs can promote bone healing, prevent bone loss, relieve pain, reduce inflammation and promote circulation.…”

Section: Discussionmentioning

confidence: 99%

Prescription patterns of Chinese herbal products for patients with fractures in Taiwan: A nationwide population-based study

Liao

Yeh

Lin

et al. 2015

Journal of Ethnopharmacology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Prescription patterns of Chinese herbal products for patients with fractures in Taiwan: A nationwide population-based study

Liao

Yeh

Lin

et al. 2015

Journal of Ethnopharmacology

View full text Add to dashboard Cite

“…For example, Spatholobus suberectus Dunn (Leguminosae) and Carthamus tinctorius L. (Asteraceae) have potent anti-platelet properties in platelet-rich plasma induced by ADP or platelet activating factor (Yan et al. 2015 ). Few reports have explored whether AP has a similar effect, but many recent reports have confirmed that AP and its compounds regulate arachidonic acid metabolic pathways (Jiao et al.…”

Section: Discussionmentioning

confidence: 99%

The antithrombosis effect of dehydroandrographolide succinate: in vitro and in vivo studies

Yin

Zhang

Huang

et al. 2022

Pharmaceutical Biology

View full text Add to dashboard Cite

Context Dehydroandrographolide succinate (DAS) is mainly used in the clinical treatment of various infectious diseases. Its potential effects on platelet aggregation and blood coagulation systems have not been reported systematically. Objective To explore whether DAS exerts an antithrombotic effect and its internal mechanism. Materials and methods Human blood samples and Sprague-Dawley (SD) rats divided into control, aspirin (30 mg/kg), and DAS groups (200, 400 and 600 mg/kg) were used to measure the platelet aggregation rate, coagulation function, coagulation factor activity, and contents of thromboxane B 2 (TXB 2 ) and 6-keto-prostaglandin F 1α (6-keto-PGF 1α ). The histopathology of the SD rat gastric mucosa was also observed. All rats were administered intragastric or intraperitoneal injections once a day for 3 consecutive days. Results Compared to control group, DAS significantly inhibited the platelet aggregation rate (ED 50 = 386.9 mg/kg) by decreasing TXB 2 levels (1531.95 ± 649.90 pg/mL to 511.08 ± 411.82 pg/mL) and activating antithrombin III (AT-III) (103.22 ± 16.22% to 146.46 ± 8.96%) ( p < 0.05). In addition, DAS significantly enhanced the coagulation factors FV (304.12 ± 79.65% to 443.44 ± 75.04%), FVII (324.19 ± 48.03% to 790.66 ± 225.56%), FVIII (524.79 ± 115.47% to 679.92 ± 143.34%), FX (34.90 ± 7.40% to 102.76 ± 29.41%) and FXI (38.12 ± 10.33% to 65.47 ± 34.08%), increased the content of Fg (2.18 ± 0.39 to 3.61 ± 0.37 g/L), shorten the PT (10.42 ± 0.44 to 9.22 ± 0.21 s), APTT (16.43 ± 1.4 to 14.07 ± 0.75 s) and TT time (37.04 ± 2.13 to 32.68 ± 1.29 s) ( p < 0.05), while the aspirin group showed no such effect on these items but showed reduced activity of FII (89.21 ± 21.72% to 61.83 ± 8.95%) and FVIII (524.79 ± 115.47% to 306.60 ± 29.96%) ( p < 0.05). Histopathological changes showed aspirin-induced gastric mucosa haemorrhage and the protective effect of DAS in the gastric mucosa. Conclusions DAS is more suitable than aspirin in thromboprophylaxis treatment, which provides a reliable theoretical and experimental basis for its clinical application.

show abstract

“…Ethyl acetate S. suberectus extract suppress the growth of human osteosarcoma Saos-2 cells in vitro [53]. Aqueous S. suberectus extract prevents the platelet-activating factors or ADP-induced aggregation of platelets in platelet-rich plasma dose dependently [54]. Sixteen phenolic bioactive constituents, including flavanols, isoflavonoids, flavanones, and chalcone, have been identified in S. suberectus extract [34].…”

Section: Discussionmentioning

confidence: 99%

In Vitro Study on Anti-Hepatitis C Virus Activity of Spatholobus suberectus Dunn

et al. 2016

View full text Add to dashboard Cite

Hepatitis C virus (HCV) infects 200 million people worldwide, and 75% of HCV cases progress into chronic infections, which consequently cause cirrhosis and hepatocellular carcinoma. HCV infection is treated with currently considered standard drugs, including direct anti-viral agents (DAAs), alone or in combination with peginterferon-α plus ribavirin. However, sustained viral responses vary in different cohorts, and high costs limit the broad use of DAAs. In this study, the ethanol and water extracts of 12 herbs from Lingnan in China were examined in terms of their inhibitory effect on HCV replication. Among the examined extracts, Spatholobus suberectus ethanol extracts suppressed HCV replication. By comparison, Extracts from Fructus lycii, Radix astragali (root), Rubus chingii Hu (fruit), Flos chrysanthemi Indici (flower), Cassia obtusifolia (seed), Lonicera japonica Thunb (flower), Forsythia suspense Thunb (fruit), Poria cocos (sclerotia), Carthamus tinctorius L. (flower), Crataegus pinnatifida Bge. (fruit), and Leonurus japonicas Houtt. (leaf) extracts failed to show a similar activity. Active S. suberectus fractions containing tannins as the major component also inhibited the in vitro translation of HCV RNA. The combination treatments of single compounds, such as epigallocatechin gallate and epicatechin gallate, were not as potent as crude S. suberectus fractions; therefore, crude S. suberectus extract may be a potential alternative treatment against HCV either alone or in combination with other agents.

show abstract

Effect of aqueous extracts of several kinds of herbs on human platelet aggregation and expression of P-selectin in vitro

Cited by 13 publications

References 15 publications

Prescription patterns of Chinese herbal products for patients with fractures in Taiwan: A nationwide population-based study

Prescription patterns of Chinese herbal products for patients with fractures in Taiwan: A nationwide population-based study

The antithrombosis effect of dehydroandrographolide succinate: in vitro and in vivo studies

In Vitro Study on Anti-Hepatitis C Virus Activity of Spatholobus suberectus Dunn

Contact Info

Product

Resources

About