Prescription patterns of Chinese herbal products for patients with fractures in Taiwan: A nationwide population-based study

Liao, Hou-Hsun; Yeh, Chia-Chou; Lin, Chun‐Pin; Chen, Bor-Chyuan; Yeh, Ming-Hsien; Chang, Kuo-Ming; Sun, Mao-Feng; Yen, Hung-Rong

doi:10.1016/j.jep.2015.07.014

Cited by 31 publications

(30 citation statements)

References 54 publications

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“…Nowadays, Traditional Chinese Medicine (TCM) has become increasingly popular as an alternative treatment for several critical illnesses, such as diabetes mellitus [4], atopic dermatitis [5], cancer [6], fractures [7], or vertigo [8]. Although previous research has indicated that several TCM herbs have shown potential benefits for dementia intervention [9], the evidence of long-term effects of TCM on dementia risk is still limited.…”

Section: Introductionmentioning

confidence: 99%

Association of traditional Chinese medicine therapy and the risk of dementia in patients with hypertension: a nationwide population-based cohort study

Chen

Yeh

Livneh

et al. 2017

BMC Complement Altern Med

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BackgroundPatients with hypertension (HTN) reportedly have a higher risk of developing dementia. However, it remains unclear if use of Traditional Chinese Medicine (TCM), the most common form of complementary and alternative medicine, can help lower the risk of dementia for these patients. So the aim of the study was to investigate the effects of TCM on dementia risk among patients with hypertension.MethodsThis longitudinal cohort study used the Taiwanese National Health Insurance Research Database (NHIRD) to identify 143,382 newly diagnosed hypertension patients aged 20–90 years who received treatment between 1998 and 2007. Among them, 52,365 (36.52%) had received TCM after the onset of hypertension (TCM users), and the remaining 91,017 patients (63.48%) were designated as a control group (non-TCM users). All enrollees were followed until the end of 2012 to record the incidence of dementia. A Cox proportional hazards regression model was used to compute the hazard ratio (HR) of dementia in patients who received TCM.ResultsDuring the 15-year follow-up, 3933 TCM users and 10,316 non-TCM users developed dementia, representing an incidence rate of 8.41 and 11.55%, respectively, per 1000 person-years. TCM users had a significantly reduced risk of dementia compared to non-TCM users (adjusted HR = 0.76; 95% confidence interval [CI] = 0.74–0.81). The predominant effect was observed among those treated with TCM longer than 180 days (adjusted HR = 0.65; 95% CI = 0.62–0.69). Among the commonly used TCM products, Tian-Ma-Gou-Teng-Yin, Dan-Shen (Radix Salviae Miltiorrhizae), Chuan-Niu-Xi (Radix Cyathulae), Ge-Gen (Radix Puerariae), Jia-Wei-Xiao-Yao-San, and Jue-Ming-Zi (Semen Cassiae) were significantly associated with a lower risk of dementia.ConclusionsResults from this population-based study support the effects of TCM on reducing dementia risk, which may provide a reference for dementia prevention strategies.

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Section: Introductionmentioning

confidence: 99%

Association of traditional Chinese medicine therapy and the risk of dementia in patients with hypertension: a nationwide population-based cohort study

Chen

Yeh

Livneh

et al. 2017

BMC Complement Altern Med

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“…SJHXT and NX were found to be important CHMs that reduced the H 2 O 2 -induced phosphorylation of both p38 MAPK and p44/42 MAPKs (Erk1/2). SJHXT is composed of 17 single herbs and has been prescribed for hundreds years for the treatment of chronic pain syndromes, including fractures [ 59 ], breast cancer [ 47 ], and prostate cancer [ 60 ]. Its pharmacological activities include anti-inflammatory and analgesic effects [ 61 ], antihypersensitivity activity [ 62 ], and the ability to increase blood circulation [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Chinese herbal medicines on the occurrence of diabetic retinopathy in type 2 diabetes patients and protection of ARPE-19 retina cells by inhibiting oxidative stress

Tsai

et al. 2017

Oncotarget

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Diabetic retinopathy is a microvascular complication of type 2 diabetes and the leading cause of acquired blindness. In Taiwan, Chinese herbal medicine (CHM) is a popular adjunctive therapy. In this study, we investigated the CHM prescription patterns and their effects. We identified 23,701 subjects with type 2 diabetes in a database, and after matching for age and gender, 6,948 patients each were assigned to CHM and non-CHM groups. In the female subgroups, the cumulative retinopathy probability was lower for the CHM users than that for the CHM non-users (P < 0.001, log-rank test). Among the top 10 CHMs, Jia-Wei-Xiao-Yao-San (JWXYS; 52.9%), Shu-Jing-Huo-Xue-Tang (SJHXT; 45.1%), and Ge-Gen-Tang (GGT; 43.7%) were the most common herbal formulas. Yan-Hu-Suo (48.1%), Ge-Gen (42.1%), and Huang-Qin (HQin; 40.1%) were the most common single herbs. CHM network analysis showed that JWXYS was the core CHM of cluster 1. JWXYS, DS, XF, and SZRT exhibited both of the reductions of H2O2-induced phosphorylation of p38 MAPK and p44/42 MAPK (Erk1/2) in human ARPE-19 retina cells. In cluster 2, SJHXT was the core CHM. SJHXT and NX showed both of the phosphorylation reductions. In cluster 3, GGT was the core CHM, and it reduced the phosphorylation of both MAPKs. In cluster 4, HQin was the core CHM, and it also reduced the phosphorylation of both MAPKs. Our study suggests that adjunctive CHM therapy may reduce diabetic retinopathy via antioxidant activity of the herbs and provides information on core CHM treatments for further scientific investigations or therapeutic interventions.

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“…The urbanization of residential areas has been described previously [19, 20]. In brief, the residential areas of Taiwan were divided into 4 levels of urbanization based on population density (people/km 2 ), the ratio of the population with varying educational levels, the ratio of elderly people, the ratio of agricultural workers, and the number of physicians per 100,000 people.…”

Section: Methodsmentioning

confidence: 99%

Complementary traditional Chinese medicine use in Children with cerebral palsy: a nationwide retrospective cohort study in Taiwan

Liao

Yen

Muo

et al. 2017

BMC Complement Altern Med

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BackgroundComplementary traditional Chinese medicine (TCM) has been used to treat patients with cerebral palsy (CP). However, large-scale surveys examining its use in the treatment of CP and associated disorders are lacking.MethodsWe enrolled 11,218 patients ≤ 18 years of age with CP in the Taiwanese National Health Insurance Research Database from 1995 to 2011. Patients were categorized as TCM users (n = 6,997; 62.37%) and non-TCM users (n = 4,221; 37.63%) based on the inclusion of TCM in their treatment plan.ResultsChildren with higher proportions of complementary TCM use were male, younger, and lived in urbanized areas. Most TCM users (n = 5332, 76.2%) visited TCM outpatient departments more than 20 times per year. In both groups, the three most common reasons for clinical visits were problems of the nervous system, respiratory system, and digestive system. Acupuncture was commonly used in problems of injury, musculoskeletal system and connective tissue, and nervous system. Chinese herbal medicine was used to improve the primary symptoms of CP in patients, as well as its associated disorders. The incidence rate ratios in allergic rhinitis, dyspepsia, menstrual disorders, and musculoskeletal system and connective tissue diseases among TCM users were significantly higher than non-TCM users. Although patients receiving complementary TCM therapies had higher medical expenditure for utilizing outpatient clinical consultations, their medical costs for visiting ER and hospitalization were significantly lower than that of non-TCM user within one year of the diagnosis of CP.ConclusionThis study was a large-scale survey to characterize patterns of complementary TCM use among children with CP. The complementary use of TCM in children with CP was considerably high. Future clinical trials and basic researches can be developed based on the findings of this study.

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Prescription patterns of Chinese herbal products for patients with fractures in Taiwan: A nationwide population-based study

Cited by 31 publications

References 54 publications

Association of traditional Chinese medicine therapy and the risk of dementia in patients with hypertension: a nationwide population-based cohort study

Association of traditional Chinese medicine therapy and the risk of dementia in patients with hypertension: a nationwide population-based cohort study

Effects of Chinese herbal medicines on the occurrence of diabetic retinopathy in type 2 diabetes patients and protection of ARPE-19 retina cells by inhibiting oxidative stress

Complementary traditional Chinese medicine use in Children with cerebral palsy: a nationwide retrospective cohort study in Taiwan

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