Effect of Aqueous Extract of Nutmeg on Hyperglycaemia, Hyperlipidaemia and Cardiac Histology Associated with Isoproterenol-induced Myocardial Infarction in Rats

Kareem, Mohammed Abdul; Krushna, Gadhamsetty Saayi; Hussain, Shaik Althaf; Devi, K. Lakshmi

doi:10.4314/tjpr.v8i4.45227

Cited by 28 publications

(19 citation statements)

References 24 publications

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“…These results are consistent with previous reports [15; 28; 31; 38]. The increased levels of serum TG and T.Ch, observed in isoproterenol-injected rats, could be attributed to the elevated flux of fatty acids, impaired removal of VLDL from the plasma [15,38], decreased lipoprotein lipase activity, and enhanced lipid biosynthesis by cardiac cyclic adenosine monophosphate cascade [15]. Isoproterenolinduced rats also showed an increase in LDL along with a decrease in HDL-cholesterol (Fig.…”

Section: Discussionsupporting

confidence: 95%

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Cardioprotective effect of resveratrol analogue isorhapontigenin versus omega-3 fatty acids in isoproterenol-induced myocardial infarction in rats

Abbas

2016

J Physiol Biochem

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Myocardial infarction (MI) is a common cause of mortality worldwide. Isorhapontigenin is a derivative of stilbene with chemical structure similar to resveratrol. The omega-3 fatty acids (FA) have beneficial effects on neurodegenerative, inflammatory, and cardiovascular diseases. The aim of this study was to investigate the effects of pretreatment with isorhapontigenin and omega-3 FA on rat model of isoproterenol-induced MI. Fifty-six rats were divided into seven groups: normal, normal + isorhapontigenin, normal + omega-3 FA, MI, MI + isorhapontigenin, MI + omega-3 FA, and MI + isorhapontigenin + omega-3 FA. Serum levels of cardiac marker enzymes [lactate dehydrogenase (LDH) and creatine kinase-MB (CK-MB)], cardiac troponin I (cTnI), inflammatory markers [tumor necrosis factor-alpha (TNF-α) and interleukin-6], and lipid profile [triglycerides, total cholesterol (T.Ch), high and low density lipoproteins (HDL, LDL), and phospholipids] as well as cardiac levels of malondialdehyde and anti-oxidants [reduced glutathione (GSH), superoxide dismutase (SOD), and catalase)] were measured in all rats. ECG and histopathological examination were performed. Isoproterenol caused a significant elevation of ST segment, decreased R wave amplitude, HDL, and anti-oxidants, and increased LDH, CK-MB, cTnI, TNF-α, interleukin-6, malondialdehyde, triglycerides, T.Ch, LDL, and phospholipids. Omega-3 FA or isorhapontigenin significantly decreased the ST segment elevation, LDH, CK-MB, cTnI, TNF-α, interleukin-6, malondialdehyde, and phospholipids and increased R wave amplitude and anti-oxidants. The effects of combined omega-3 FA and isorhapontigenin were more significant than either of them alone. Therefore, we conclude that omega-3 FA and isorhapontigenin have a cardioprotective effect on rats with isoproterenol-induced MI through their anti-oxidant and anti-inflammatory actions.

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Section: Discussionsupporting

confidence: 95%

“…Lipids play a key role in the pathogenesis of CVD, not only by way of hyperlipidemia and the development of atherosclerosis but also by modifying the composition, structure, and stability of cellular membranes [15]. Isoproterenol-treated rats showed an increase in serum level of TG and T.Ch (Fig.…”

Section: Discussionmentioning

confidence: 97%

Cardioprotective effect of resveratrol analogue isorhapontigenin versus omega-3 fatty acids in isoproterenol-induced myocardial infarction in rats

Abbas

2016

J Physiol Biochem

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“…Lipids play an important role in cardiovascular disease, not only by way of hyperlipidemia and the development of atherosclerosis, but also by modifying the Table I Effect of Sechium edule on ISO induced alterations in serum levels of marker enzymes in rats composition, structure and stability of cellular membranes (Kareem et al, 2009). The increased levels of plasma cholesterol and triglycerides observed in isoproterenol-injected rats could be due to increased lipolysis.…”

Section: Discussionmentioning

confidence: 99%

Cardioprotective activity of fruits of <i>Sechium edule</i>

Neeraja¹,

Debnath²,

Firdous³

2015

Bangladesh J Pharmacol

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The present work deals with the study of the ethanolic extract of fruits of Sechium edule for cardioprotective activity. Cardioprotective activity of the ethanolic extract of fruits of S. edule was determined by the administration of isoproterenol (60 mg/kg, s.c) for two days. Pretreatment with S. edule (200 mg/kg, p.o and 100 mg/kg, p.o) for 28 days in significantly (p<0.01) reduce the levels of serum transaminases, alkaline phosphates, lactate dehydrogenase, creatinine kinase, total cholesterol, triglycerides, LDL-cholesterol, VLDL-cholesterol and increase the levels of HDL-cholesterol. Histopathological studies of the hearts of isoproterenol treated rats have shown infiltration of inflammatory cells and continuity in muscle fiber was lacking suggesting an irreversible cell injury. Animals treated with ethanolic extract of S. edule showed less degenerative changes compared to isoproterenoltreated animals. Article Info

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“…The search for an effective medicine to treat cardiovascular disorders without any side effects has lead to the use of traditional plant based medicine. The indigenous plants such as Aegle marmelos (Krushna et al, 2011), Inula racemosa (Ojha et al, 2011), Punica granatum (Mohan et al, 2010), Myristica fragrans (Kareem et al, 2009), Moringa oleifera (Nandave et al, 2009) and Embelia ribes Burm (Bhandari et al, 2008) have been proved for their cardioprotective activity against ISO-induced MI in rats.…”

Section: Introductionmentioning

confidence: 99%

Cardioprotective effect of HPLC standardized ethanolic extract of Terminalia pallida fruits against isoproterenol-induced myocardial infarction in albino rats

Shaik

Rasool²,

Reddy

et al. 2012

Journal of Ethnopharmacology

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Effect of Aqueous Extract of Nutmeg on Hyperglycaemia, Hyperlipidaemia and Cardiac Histology Associated with Isoproterenol-induced Myocardial Infarction in Rats

Cited by 28 publications

References 24 publications

Cardioprotective effect of resveratrol analogue isorhapontigenin versus omega-3 fatty acids in isoproterenol-induced myocardial infarction in rats

Cardioprotective effect of resveratrol analogue isorhapontigenin versus omega-3 fatty acids in isoproterenol-induced myocardial infarction in rats

Cardioprotective activity of fruits of <i>Sechium edule</i>

Cardioprotective effect of HPLC standardized ethanolic extract of Terminalia pallida fruits against isoproterenol-induced myocardial infarction in albino rats

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