Effect of antiepileptic drug (Topiramate) and cold pressed ginger oil on testicular genes expression, sexual hormones and histopathological alterations in mice

Makawy, Aida I. El; Ibrahim, Faten M.; Mabrouk, Dalia M.; Ahmed, Kawkab A.; Ramadan, Mohamed Fawzy

doi:10.1016/j.biopha.2018.11.146

Cited by 24 publications

(13 citation statements)

References 56 publications

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“…Ginger juice markedly reduced expression of iNOS and NF‐κB and levels of NO, TNF‐α, IL‐6 and IL‐1β in the testis. Published papers have suggested anti‐inflammatory capacity of ginger extract and its constituent potent bioactive compounds by suppressing inflammatory cascade reaction (Akinyemi & Adeniyi, 2018; El Makawy et al., 2019; Kaygusuzoglu et al., 2018). However, to our best knowledge, there is no investigation suggesting anti‐inflammatory effect of ginger juice extract against CIS so far.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies report the protective effects of ginger extracts against toxicities induced by toxicants (Reddy, Chalamaiah, Ramesh, Balaji, & Indira, 2014). The recent study of El Makawy, Ibrahim, Mabrouk, Ahmed, and Ramadan (2019) reports that ginger oil prevents testicular damage and sex hormone disruption induced by antiepileptic drug via antioxidant action in mice. Experimental oxidative nephrotoxicity induced by an anticancer drug, doxorubicin, was ameliorated by ginger extract (Ajith, Aswathy, & Hema, 2008).…”

Section: Introductionmentioning

confidence: 99%

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Ginger juice prevents cisplatin‐induced oxidative stress, endocrine imbalance and NO/iNOS/NF‐κB signalling via modulating testicular redox‐inflammatory mechanism in rats

Famurewa¹,

Ekeleme‐Egedigwe²,

Onwe

et al. 2020

Andrologia

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Chemotherapy is a cornerstone option in cancer treatment owing to its efficacy and effect on quality of life of cancer patients. The action mechanism of anticancer agents is targeted at deregulating cell cycle machinery and inhibiting unscheduled proliferation of cancer cells (Lin et al., 2020). Unfortunately, chemotherapeutic anticancer drugs often exert deleterious effect on healthy cells and tissues leading to systemic toxicity (Negrette-Guzmán, 2019). The toxicity may become unbearable that the treatment regimen has to be disrupted, even when achieving tumoricidal efficacy (Lin et al., 2020). Cisplatin (CIS) is an efficacious anticancer agent; it is the first choice for the treatment of advanced nonsmall-cell lung cancer cells, breast cancer and ovarian cancer (Browning et al., 2017; Lin et al., 2020; Manohar & Leung, 2018). It is of significant value also in the treatment of germ cell and testicular cancers (Thurston, 2007). It unleashes its anticancer action through formation of cisplatin-DNA adduct by intrastrand cross-links due to interaction with cancer cell DNA purine bases eventually leading to p53 activation, cell cycle arrest and induction

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ginger juice prevents cisplatin‐induced oxidative stress, endocrine imbalance and NO/iNOS/NF‐κB signalling via modulating testicular redox‐inflammatory mechanism in rats

Famurewa¹,

Ekeleme‐Egedigwe²,

Onwe

et al. 2020

Andrologia

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“…TPM in doses of 50 mg, 100 mg, and 200 mg/Kg body weight was administered orally. The doses of TPM were selected based on earlier studies [ [15] , [16] , [17] ].…”

Section: Methodsmentioning

confidence: 99%

Gastro protecting influence of Topiramate in ethanol produced gastric ulcers in rats

Kadasah¹,

Eid²,

Alawad³

et al. 2021

Toxicology Reports

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“…Bax expression level in the brain sections was examined according to El makawy et al [40] Sections were incubated with primary antibodies against Bax (1:100 dilution) (Santa Cruz Biotechnology Inc., Dallas, TX, USA). The immune reaction was visualized using diaminobenzidine tetrachloride (DAB, Sigma, St. Louis, MO, USA).The positive immune reactive cells showed brown-stained cytoplasm.…”

Section: Bax Expressionmentioning

confidence: 99%

Topamax® and Ginger Oil Potential Neurotoxicity And Their Interaction in Mice Thru Oxidative Stress and Inflammatory Markers, Neurotransmitters Expression and Immunohistochemical Measurements

Mabrouk

Makawy

Ahmed

et al. 2022

Preprint

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Background: Topamax® ® has multiple pharmacological mechanisms that are efficient to treat epilepsy and migraine. Ginger has been demonstrated to have gingerols and shogaols compounds that proven to cross the blood-brain barrier causing migraine relief, implying that it is useful in the treatment of migraines. Moreover, Topamax has many off-label uses. So it was necessary to explore the possible neurotoxicity of Topamax®, Ginger oil and their interaction in the mice brain. Methods and Results: Male mice were orally gavage with Topamax®, ginger oil (400mg/kg), and Topamax® plus ginger oil with the same pattern for one month. Oxidative stress markers, acetylcholinesterase (AchE) and gamma aminobutyric acid (GABA) and tumor necrosis factor-alpha (TNF- α), were analyzed in brain tissue. Histopathological examination by hematoxylin and eosin, immunohistochemical glial fibrillary acidic protein (GFAP), and Bax expression analysis were done. The mRNA levels of GABAAR subunits, Gabra1, Gabra3, and Gabra5 were evaluated by RT qPCR. The analysis of data revealed that Topamax® elevated the levels of oxidative stress markers, neurotransmitters, TNF-α, and diminished the level of glutathione reduced (GSH). Topamax® exhibited various neuropathological alterations, strong Bax expression, and GFAP immune-reactivity in the cerebral cortex. The interaction effect of Topamax® plus ginger oil attenuated the changes induced by Topamax® in the abovementioned parameters. Both Topamax® and ginger oil upregulated the mRNA expression of gabra1 and gabra3 while their interaction markedly downregulated them. Conclusion: We can conclude that the Topamax® overdose could possibly cause neurotoxicity, but the interaction with ginger oil can reduce Topamax® -induced neurotoxicity and should be taken in parallel.

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Effect of antiepileptic drug (Topiramate) and cold pressed ginger oil on testicular genes expression, sexual hormones and histopathological alterations in mice

Cited by 24 publications

References 56 publications

Ginger juice prevents cisplatin‐induced oxidative stress, endocrine imbalance and NO/iNOS/NF‐κB signalling via modulating testicular redox‐inflammatory mechanism in rats

Ginger juice prevents cisplatin‐induced oxidative stress, endocrine imbalance and NO/iNOS/NF‐κB signalling via modulating testicular redox‐inflammatory mechanism in rats

Gastro protecting influence of Topiramate in ethanol produced gastric ulcers in rats

Topamax® and Ginger Oil Potential Neurotoxicity And Their Interaction in Mice Thru Oxidative Stress and Inflammatory Markers, Neurotransmitters Expression and Immunohistochemical Measurements

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