Effect of Antibacterials, Antibiotics, Enzymes and Steroids on Phagocytosis

Seneca, F.A.C.P. Harry; Peer, B S Pat

doi:10.1111/j.1532-5415.1966.tb05308.x

Cited by 20 publications

(2 citation statements)

References 28 publications

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“…Normal phagocytosis and intracellular killing of staphylo cocci have been reported [4,17], while other studies show a marked PMN bactericidal defect [8]. Corticosteroids, because of their ability to prevent granule membranes from rupturing, may inhibit ingestion or interfer with the degranulation mechanism itself [48], PMNs from healthy donors subjected to glucocorticoid treatment ingested and killed bacteria in a normal fashion [47] while in other studies, steroids were shown to in hibit PMN bacterial phagocytosis [10,40] and to impair their ability to kill intracellularly [2,30,34], Steroids inhibit in vitro, hexose monophos phate shunt activity, the iodination of some types of bacteria [9] and NADH oxidase activity [30], while the PMNs of patients receiving ster oids showed suppressed reduction of nitrobluetetrazolium [30].…”

Section: Discussionmentioning

confidence: 99%

Defective Immune and Phagocytic Functions in Uraemia and Renal Transplantation

McIntosh

Hansen

Ziegler

et al. 1976

Int Arch Allergy Immunol

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The humoral, cellular and neutrophil responses of uraemic patients maintained by haemodialysis were compared with those of renal transplant recipients. Humoral immunity was reduced only in the transplant group. Cell-mediated immunity was abnormal in both groups but more decreased in the transplant group studied particularly within 3 months of transplantation. The neutrophil bactericidal capacities were defective in both groups. Infectious complications were often associated with defective cellular immunity, but fatal infections occurred only in transplant patients over 40 years of age with combined cellular and neutrophil defects. No single test was predictive of graft survival in uraemic patients. The depressed cellular immune responses in uraemia, of the degree seen in the immunosuppressed transplant recipient, may explain the better prognosis of renal transplants compared with other organ transplants.

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Section: Discussionmentioning

confidence: 99%

Defective Immune and Phagocytic Functions in Uraemia and Renal Transplantation

McIntosh

Hansen

Ziegler

et al. 1976

Int Arch Allergy Immunol

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“…Previous studies [7] have suggested that LZM might act in certain circumstances as an opsonin in the phago cytosis of bacteria, independently of the LZM sensitivity of the bacteria. Lycke et al [10] and Seneca and Peer [15] have also described an en hancing effect of high concentrations (1,000 ,i/g/ml) of hen egg white LZM on the phagocytosis of Toxoplasma gondii by HeLa cells, and of Proteus vulgaris and Streptococcus haemolyticus by human PMN. With respect to the present studies, it is particularly noteworthy that the stimulation of phagocytosis was demonstrated only with the homologous human LZM, and that the concentrations used are probably within the range achieved in inflammatory exudates in vivo [16].…”

Section: Discussionmentioning

confidence: 99%

Stimulation of Phagocytosis by Human Lysozyme

Klockars¹,

Roberts²

1976

Acta Haematol

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Human lysozyme in physiologic concentrations (10–400 μg/ml) significantly (p < 0.001) stimulates the phagocytosis of yeast cells by human polymorphonuclear leukocytes. This stimulating effect was observed even in the absence of serum factors. Hen egg white lysozyme or protamine sulfate had no effect on phagocytosis. The stimulating effect of human lysozyme was not the result of opsonization but was apparently related to the effects on constituent membranes of the phagocytic cells.

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Effect of amoxycillin and doxycycline on function of human granulocytes tested in vitro and on chemotaxis of granulocytes from rabbits given the two antibiotics

Grec

Frei

1984

Inflammation

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The effect of amoxycillin and doxycycline on human granulocyte function was studied in vitro. The antimicrobial agents were added to tests of chemotaxis, random motility, yeast phagocytosis, and killing, at progressing concentrations. The effect was also evaluated in vivo by measuring chemotaxis and random motility (agarose technique) of granulocytes from rabbits injected with these antibiotics. Amoxycillin was shown to have a slightly stimulating effect on chemotaxis, demonstrable only at the highest concentration tested (100 micrograms/ml), and no effect on the other variables. Doxycycline had a dose-related inhibitory effect on chemotaxis, random motility, and phagocytosis, and no effect on killing. Chemotaxis and random motility were slightly, but not significantly, stimulated in vivo when rabbits were given amoxycillin. Chemotaxis (but not random motility) was significantly impaired when the rabbits were given doxycycline.

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Effect of Antibacterials, Antibiotics, Enzymes and Steroids on Phagocytosis

Cited by 20 publications

References 28 publications

Defective Immune and Phagocytic Functions in Uraemia and Renal Transplantation

Defective Immune and Phagocytic Functions in Uraemia and Renal Transplantation

Stimulation of Phagocytosis by Human Lysozyme

Effect of amoxycillin and doxycycline on function of human granulocytes tested in vitro and on chemotaxis of granulocytes from rabbits given the two antibiotics

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