Effect of Alprostadil on Colorectal Anastomoses Under Relative Ischemia

Ruiz-Luque, Virgilio; Parra-Membríves, Pablo; Escudero-Severín, Carlos; Aguilar-Luque, José

doi:10.1016/j.jss.2018.11.046

Cited by 4 publications

(2 citation statements)

References 19 publications

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“…In the inflammatory phase, white blood cells are involved in the mobilization and activation of fibroblasts and epithelial cells [13]. Chemotactic agents, cytokines and inflammatory cells are concentrated in the anastomotic area from the second postoperative day [14]. In the current study, inflammation was more common in the red ginseng group than in the sham group and control group.…”

Section: Discussionmentioning

confidence: 44%

Does Rectal Application of Red-Ginseng have an Effect on Colorectal Anastomosis Healing? An Experimental Study

Şenlikçi¹,

Koşmaz

Durhan

et al. 2021

Archives of Clinical and Experimental Medicine

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Aim: To evaluate the possible effects of red-ginseng on colon anastomosis healing in an experimental rat model. Methods: In Group 1 (sham), laparotomy and colonic mobilization were performed. Colonic transection and anastomosis were performed to Groups 2 and 3. In Group 2 (control), 2 ml of saline was administered rectally to all rats for 10 days. Group 3 (drug group) rats were given 2.5 gr/kg ml red ginseng extract rectally for 10 days. Results: The rats in the sham group had the highest bursting pressure and the rats in the red ginseng group had higher bursting pressure than in the control group (p<0.05). A significant difference was observed only for the total SH level between the control group and the red ginseng group (p= 0.008). The red ginseng group had the highest scores for all parameters in the histopathological evaluation and the differences were significant compared to both the sham group and the control group. Conclusion: Rectally administered red-ginseng significantly increased wound healing parameters and increased anastomotic burst pressure. This is the first study in the literature on the beneficial effects of red-ginseng on colorectal anastomoses.

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Section: Discussionmentioning

confidence: 44%

Does Rectal Application of Red-Ginseng have an Effect on Colorectal Anastomosis Healing? An Experimental Study

Şenlikçi¹,

Koşmaz

Durhan

et al. 2021

Archives of Clinical and Experimental Medicine

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“…However, it could be hypothesized that this might represent a point of therapeutic intervention, as animal models suggest that PGD2 metabolites ameliorates inflammation [46]. Similarly, the sustained reduction of PGE 1 , 13-HODE, and 13-oxo-ODE in UC, which are all antiinflammatory eicosanoids and improve the microcirculation [47], may be substituted, as animal [48] and human [49] studies have shown increased wound healing times with the infusion of PGE1.…”

Section: Discussionmentioning

confidence: 99%

Lipidomic Trajectories Characterize Delayed Mucosal Wound Healing in Quiescent Ulcerative Colitis and Identify Potential Novel Therapeutic Targets

Bjerrum¹,

Wang²,

Zhang³

et al. 2022

Int. J. Biol. Sci.

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Improving the long-term prognosis of ulcerative colitis (UC) requires sustained deep mucosal colonic healing with histologic remission, making the study of colonic tissue regeneration essential. In experimental colitis models, lipid metabolites are recognized as pivotal components of this process. This study aimed to describe the kinetics of wound healing and lipid metabolites engaged in regeneration in the normal colonic mucosa and how they are affected in UC to reveal new therapeutic targets. Experimental colonic wounds were created endoscopically in quiescent UC (n=21) and controls (n=9), and the healing process was surveilled by serial endoscopies and cross-sectional wound biopsies post-wounding. Biopsies were analyzed by liquid chromatography coupled with mass spectrometry. Endoscopic wound scores were significantly higher in UC at day two (p=0.001) and seven (p<0.0001) post-wounding, demonstrating a prolonged wound healing process. The wound scores were correlated with lipid mediators crucial for normal regeneration and sustained UC-specific changes in key phospholipids and eicosanoids, i.e., lysophosphatidylcholine, phosphatidylcholine, lysophosphatidic acid, phosphatidylglycerol, phosphatidylinositol, prostaglandin D2, and prostaglandin E1, were observed. A prolonged wound healing process is identified in quiescent UC with altered disease specific lipidomic trajectories providing potential novel therapeutic avenues for stimulating mucosal regeneration as an add-on to the traditional immune suppression treatment.

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The Effect of Genistein on Anastomotic Healing in Intestinal Ischemia/Reperfusion Injury

Akıncı

Tosun

Kepil

2022

Journal of Surgical Research

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Effect of Alprostadil on Colorectal Anastomoses Under Relative Ischemia

Cited by 4 publications

References 19 publications

Does Rectal Application of Red-Ginseng have an Effect on Colorectal Anastomosis Healing? An Experimental Study

Does Rectal Application of Red-Ginseng have an Effect on Colorectal Anastomosis Healing? An Experimental Study

Lipidomic Trajectories Characterize Delayed Mucosal Wound Healing in Quiescent Ulcerative Colitis and Identify Potential Novel Therapeutic Targets

The Effect of Genistein on Anastomotic Healing in Intestinal Ischemia/Reperfusion Injury

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