Effect of alginate composition on profile release and characteristics of chitosan-alginate microparticles loaded with mangosteen extract

Mulia, Kamarza; Halimah, Nur; Krisanti, Elsa Anisa

doi:10.1063/1.4978083

Cited by 15 publications

(12 citation statements)

References 20 publications

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“…The results of SEM clearly showed that α-M existed on the surface of ChAlg HF ( Figure 2B) with the halo pattern of Alg-Ch, whether the Alg HF was less homogenous than ChAlg HF. This polyelectrolyte complex film surfaces showed the irregular and porous properties similar to the results in the previous studies [29,30,32,33].…”

Section: Preparation and Physicochemical Characterizationssupporting

confidence: 85%

“…In addition, complexation of polyelectrolytes leads to coacervate and form hydrogel [28]. α-M probably entrapped in the network through the 21st and 22nd hydrogen atom of Alg to fill in the voids between Ch-Alg, thus smoothing the surface of the HFs [29,30]. These results confirm that the interaction between Ch, Alg, and α-M occurred by hydrogen bonding, verifying α-M as a receptor and Alg as a donor.…”

Section: Molecular Dockingsupporting

confidence: 59%

“…HFs were weighed and soaked in 2 mL of 20% TCA or trypsin solutions, then incubated for 24 h. Figure 5A,B described that not only in TCA, but also in trypsin solutions, ChAlg HF and ChAlg/α-M HF significantly improved the degradability of HFs compared to Ch HF and Alg HF, respectively. In another study, combination of Alg and Ch (2:1) as a microparticle loaded mangosteen rind extract increased 2-fold in releasing α-M from HFs in the colon and intestine compared to a low alginate concentration (0.25:1) [30]. Based on these results, Alg increased the degradability of Ch, and closely related to the release time of α-M from ChAlg HF.…”

Section: Degradability Studymentioning

confidence: 91%

“…As we can see in Figure 7A, the burst release in 2 h was necessary for RAS therapy to provide quick onset of action in oral mucous. Previous study reported that the release of α-M from Ch-Alg microparticle after being immersed in simulated gastric fluid (SGF) and simulated colon fluid (SCF) were burst released for 2 h. The release of α-M in acidic media decreased in the higher Alg concentration, but in neutral condition (in SCF and simulated intestinal fluid/SIF) the presence of Alg increased the α-M release [30]. This phenomenon was caused by the chain relaxation in the electrostatic interaction from the carbonyl group in Alg and amino group in Ch [30,44].…”

Section: In Vitro Release Studymentioning

confidence: 98%

“…To observe the release mechanism of α-M from ChAlg HF, an in vitro release study of ChAlg/α-M HF was performed in PBS solution (pH 7.4) at 5,15,30,45,60,90, and 120 min. The concentrations of α-M were measured by UV spectrophotometry at wavelength of 246 nm [24].…”

Section: In Vitro Release Studymentioning

confidence: 99%

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α-Mangostin Hydrogel Film Based Chitosan–Alginate for Recurrent Aphthous Stomatitis

et al. 2019

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Featured Application: This study highlights a novel application of α-mangostin hydrogel film based chitosan-alginate. α-mangostin has been known as an agent for oral cavity therapy. However, α-mangostin is difficult to be delivered directly to the site. This novel application of hydrogel film-based chitosan-alginate have the potential as carriers of α-mangostin for recurrent aphthous stomatitis therapy.Abstract: Many antiseptic drugs, local anaesthetics, and corticosteroids have been used for effective therapy of recurrent aphthous stomatitis (RAS). However, these drugs have harmful side effects. α-mangostin (α-M), a main compound of mangosteen (Garcinia mangostana L.) peel, has been known as a wound healing agent. In addition, hydrogel film as dressings designed to separate mucosal lesions from the oral environment, and improve the effectiveness of RAS therapy. The purpose of this study was to develop α-M hydrogel film based chitosan-alginate (ChAlg/α-M HF) for RAS. The in silico study by Discovery studio visualizer and AutoDock confirmed that hydrogen bonding between Ch, Alg, and α-M occurred. The results of physicochemical characterizations by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and X-ray diffraction (XRD) indicated that the ChAlg/α-M HF had a lower crystalline form compared to pure α-M. In addition, ChAlg/α-M HF significantly improved the swelling ratio and tensile strength compared to that of ChAlg HF. Moreover, the existence of Alg increased the degradability of Ch, and closely related to the release of α-M from ChAlg HF. The in vitro release study confirmed that the release of α-M from ChAlg/α-M HF was the Fickian diffusion model. Finally, the mucoadhesive study revealed that ChAlg/α-M HF had a good mucoadhesive property. These results suggest that hydrogel film-based chitosan-alginate have the potential as carriers of α-M for RAS therapy.

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Section: Preparation and Physicochemical Characterizationssupporting

confidence: 85%

Section: Molecular Dockingsupporting

confidence: 59%

Section: Degradability Studymentioning

confidence: 91%

Section: In Vitro Release Studymentioning

confidence: 98%

Section: In Vitro Release Studymentioning

confidence: 99%

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α-Mangostin Hydrogel Film Based Chitosan–Alginate for Recurrent Aphthous Stomatitis

et al. 2019

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Characteristics and Bioactivities of Carrageenan/Chitosan Microparticles Loading α-Mangostin

Nguyễn

Nguyen

et al. 2021

J Polym Environ

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This study attempted to develop carrageenan/chitosan based microparticles loading α-mangostin which was extracted from Vietnamese mangosteen skin. The carrageenan/chitosan/α-mangostin microparticles were prepared by ionic gelation method by mixing chitosan, carrageenan with α-mangostin and subsequently crosslinking the mixtures with sodium tripolyphosphate crosslinking agent. The content of α-mangostin in microparticles was changed to evaluate the effect of α-mangostin content on physical, morphological properties, particles size and bioactivities of the carrageenan/chitosan/α-mangostin microparticles. The obtained results showed that carrageenan, chitosan was interacted together and with α-mangostin. The presence of polymers matrix improved the release ability of α-mangostin into ethanol/pH buffer solutions. The carrageenan/chitosan/ α-mangostin microparticles have antibacterial (gram (+) strains) and anti-oxidant activities. The results suggested that combination of chitosan and carrageenan in the microparticles can enhance the control release of αmangostin into solutions as well as keep the bioactivities of α-mangostin.

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Evaluation of encapsulated microparticles of Garcinia mangostana L. extracts on marker SGOT, SGPT, BUN and creatinine serum of BALB/c mice

Diba

Purba

Wienarno

et al. 2019

AIP Conference Proceedings

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Effect of alginate composition on profile release and characteristics of chitosan-alginate microparticles loaded with mangosteen extract

Cited by 15 publications

References 20 publications

α-Mangostin Hydrogel Film Based Chitosan–Alginate for Recurrent Aphthous Stomatitis

α-Mangostin Hydrogel Film Based Chitosan–Alginate for Recurrent Aphthous Stomatitis

Characteristics and Bioactivities of Carrageenan/Chitosan Microparticles Loading α-Mangostin

Evaluation of encapsulated microparticles of Garcinia mangostana L. extracts on marker SGOT, SGPT, BUN and creatinine serum of BALB/c mice

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