Effect of Agmatine on Actin Polymerization Dynamics in Wga-Stimulated Leukocytes Under Diabetes Mellitus in Rats

Brodyak, I. V.; Bila, I.I.; Sybirna, N.O.

doi:10.15407/fz63.04.048

Cited by 1 publication

(2 citation statements)

References 19 publications

(30 reference statements)

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“…Simultaneous formation of NO and О 2 •– in inflammatory sites can also lead to the formation of secondary ROS, such as peroxynitrite. This reactive oxidant plays a key role, both in the protection of the host and in the pathogenesis of inflammatory diseases (Beckman and Koppenol, 1996; Lupak et al, 2017; Brodyak et al, 2018).…”

Section: Nitration Of Proteins In Different Pathological Conditionsmentioning

confidence: 99%

“…Nitration of tyrosine that occupies 294 position in the actin protein molecule impairs actin polymerization and destabilizes F‐actin bundles (Varland et al, 2019). As actin plays one of the key roles in ensuring neutrophils functional activity (Lupak et al, 2017; Brodyak et al, 2018) it can be speculated that it may be an important functional target of nitration. Peroxynitrite was found to inhibit neutrophil actin polymerization, resulting in impaired migration, phagocytosis, and NADPH‐oxidase activity.…”

Section: Nitration Of Proteins In Different Pathological Conditionsmentioning

confidence: 99%

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Tyrosine nitration as a key event of signal transduction that regulates functional state of the cell

Sabadashka

Nagalievska

Sybirna

2020

Cell Biology International

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This review is dedicated to the role of nitration of proteins by tyrosine residues in physiological and pathological conditions. First of all, we analyze the biochemical evidence of peroxynitrite formation and reactions that lead to its formation, types of posttranslational modifications (PTMs) induced by reactive nitrogen species, as well as three biological pathways of tyrosine nitration. Then, we describe two possible mechanisms of protein nitration that are involved in intracellular signal transduction, as well as its interconnection with phosphorylation/dephosphorylation of tyrosine. Next part of the review is dedicated to the role of proteins nitration in different pathological conditions. In this section, special attention is devoted to the role of nitration in changes of functional properties of actin—protein that undergoes PTMs both in normal and pathological conditions. Overall, this review is devoted to the main features of protein nitration by tyrosine residue and the role of this process in intracellular signal transduction in basal and pathological conditions.

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Section: Nitration Of Proteins In Different Pathological Conditionsmentioning

confidence: 99%

Section: Nitration Of Proteins In Different Pathological Conditionsmentioning

confidence: 99%

Tyrosine nitration as a key event of signal transduction that regulates functional state of the cell

Sabadashka

Nagalievska

Sybirna

2020

Cell Biology International

View full text Add to dashboard Cite

show abstract

Effect of Agmatine on Actin Polymerization Dynamics in Wga-Stimulated Leukocytes Under Diabetes Mellitus in Rats

Cited by 1 publication

References 19 publications

Tyrosine nitration as a key event of signal transduction that regulates functional state of the cell

Tyrosine nitration as a key event of signal transduction that regulates functional state of the cell

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