Effect of Aging and Anthropometric Measurements on Nerve Conduction Properties - A Review

Jagga, M; Lehri, Anuradha; Verma, SK

doi:10.18376//2011/v7i1/67617

Cited by 14 publications

(12 citation statements)

References 21 publications

(27 reference statements)

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“…We expected to see a shorter delay time between stimulus and onset of response in SCD patients because of the autonomic hypersensitivity suggested by sigh‐induced vasoconstriction in SCD patients, and hypersensitivity to pain in sickle mice in direct neuron recordings . However, while this was apparent in the univariable analysis (Supporting Information Table S2), the difference in delay between pain and vasoconstriction in our data was related to participant's age ( P = .01) in the multivariable model, which is consistent with the known slowing of nerve conduction velocity with increasing age …”

Section: Discussionsupporting

confidence: 78%

Individuals with sickle cell disease have a significantly greater vasoconstriction response to thermal pain than controls and have significant vasoconstriction in response to anticipation of pain

et al. 2017

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The painful vaso-occlusive crises (VOC) that characterize sickle cell disease (SCD) progress over hours from the asymptomatic steady-state. SCD patients report that VOC can be triggered by stress, cold exposure and pain itself. We anticipated that pain could cause neural-mediated vasoconstriction, decreasing regional blood flow and promoting entrapment of sickle cells in the microvasculature. Therefore, we measured microvascular blood flow in the fingers of both hands using plethysmography and laser-Doppler flowmetry while applying a series of painful thermal stimuli on the right forearm in 23 SCD patients and 25 controls. Heat pain applied to one arm caused bilateral decrease in microvascular perfusion. The vasoconstriction response started before administration of the thermal pain stimulus in all subjects, suggesting that pain anticipation also causes significant vasoconstriction. The time delay between thermal pain application and global vasoconstriction ranged from 5 to 15.5 seconds and increased with age (p < 0.01). Although subjective measures, pain threshold and pain tolerance were not different between SCD subjects and controls, but the vaso-reactivity index characterizing the microvascular blood flow response to painful stimuli was significantly higher in SCD patients (p = .0028). This global vasoconstriction increases microvascular transit time, and may promote entrapment of sickle cells in the microvasculature, making vaso-occlusion more likely. The rapidity of the global vasoconstriction response indicates a neural origin that may play a part in the transition from steady-state to VOC, and may also contribute to the variability in VOC frequency observed in SCD patients.

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Section: Discussionsupporting

confidence: 78%

Individuals with sickle cell disease have a significantly greater vasoconstriction response to thermal pain than controls and have significant vasoconstriction in response to anticipation of pain

et al. 2017

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“…[2] NCV decreases with age owing to decreased number of nerve fiber, a reduction in fiber diameter, and changes in the fiber membrane. [11] However, the values normally change by less than 10 m/s by the 60 th year or even the 80 th year. [12] On comparing our study for the adults between 20 and 60 years, the NCV for elbow-wrist segment found to be less than that of Chouhan [13] but more than that of Ginzberg et al [14] and Kimura et al [15] ( Table 5).…”

Section: Agementioning

confidence: 99%

Nerve conduction velocity in median nerve of healthy adult population in Malwa region of Madhya Pradesh with respect to age, gender, and height along with the relation amongst them

Kumar¹,

Dutta²,

Prasad³

et al. 2017

Natl J Physiol Pharm Pharmacol

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Background: Nerve conduction velocities (NCV) represent the most accurate methods to study the peripheral nerves owing to their ability in diagnosing nerve-related conditions. It helps to distinguish between a true nerve disorder and conditions where muscles are affected due to a nerve injury. However, there are considerable differences in reference values for NCV in different nerves with respect to region, gender, population, and various anthropological data such as age, height, body mass index, and temperature. They have to be kept in mind while doing nerve conduction studies as these anthropological factors vary according to the different geographical areas. Aim and Objectives: The aim of this study is to establish the electrophysiological data NCV for the right median nerve in normal healthy adults in Malwa region of Indore, district of Madhya Pradesh, and to study the effect of age, gender, and height on it along with relation among them. Materials and Methods: A total 118 healthy participants (38 females and 80 males) between the ages of 20 and 60 years, with no neurological problem were investigated at

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“…[2] Nerve conduction velocity decreases with age owing to decreased number of nerve fiber, a reduction in fiber diameter, and changes in the fiber membrane. [12] But, the values normally change by less than 10 m/s by the sixtieth year or even the eightieth year. [10] The amplitude of the sensory nerve action potential (SNAP) and CMAP may also be affected by age.…”

Section: Discussionmentioning

confidence: 99%

“…The reduced amplitude is best related to loss of axons. [12] It is estimated that the SNAP amplitude may decrease by as much as 50% in a 70-year-old patient. [2] Motor CMAP amplitudes decline with aging, although this decrease is much less marked than that seen with SNAP.…”

Section: Discussionmentioning

confidence: 99%

Normative data of upper limb motor nerve conduction in Northern Kerala population and effect of height on motor nerve conduction velocity

H¹,

Govindan²,

Zubaida³

et al. 2016

Natl J Physiol Pharm Pharmacol

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constitutes the recording, display, and estimation of action potentials originating from central nervous system (evoked potentials), peripheral nerves (nerve conduction assessments), and muscles (electromyography). [2] Nerve conduction studies (NCSs) are part of electrodiagnostic procedures, which helps in diagnosing abnormalities of nerves. NCSs provide a means of confirming the presence and extent of peripheral nerve damage. These studies can diagnostically aid in patients alleged of experiencing nearly any disorder of peripheral nervous system, comprising disorders of nerve roots, peripheral nerves, and muscle and neuromuscular junctions. [3] NCSs include motor conduction studies, sensory conduction studies, and late response studies. Motor conduction

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Effect of Aging and Anthropometric Measurements on Nerve Conduction Properties - A Review

Cited by 14 publications

References 21 publications

Individuals with sickle cell disease have a significantly greater vasoconstriction response to thermal pain than controls and have significant vasoconstriction in response to anticipation of pain

Individuals with sickle cell disease have a significantly greater vasoconstriction response to thermal pain than controls and have significant vasoconstriction in response to anticipation of pain

Nerve conduction velocity in median nerve of healthy adult population in Malwa region of Madhya Pradesh with respect to age, gender, and height along with the relation amongst them

Normative data of upper limb motor nerve conduction in Northern Kerala population and effect of height on motor nerve conduction velocity

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