Effect of Aerobic Exercise on Liver Tissue in Rats with NAFLD

Abstract

Objective. To observe the improvement effect of aerobic exercise on liver tissue of rats with NAFLD, explore whether it can reduce NAFLD symptoms without drug dependence, and provide certain data support for the relief of NAFLD by aerobic exercise. Methods. 40 healthful male SD rats have been divided into ordinary diet and high-fat diet. To observe whether the molding is forming after 6 weeks, then divide the rats into control (C), model (M), and exercise (E) group. E group received 8-week aerobic exercise intervention. Serum and liver samples were taken and analyzed after the last intervention. Results. The morphological of hepatocytes between C and M group becomes different, and the accumulation of fat and inflammatory cells was significant, suggesting that NAFLD symptoms appeared, that is, the model was successfully established. Compared with M group, the morphology of rats in E group was improved in varying degrees. The quantity of ALT, AST, and MDA of rats in M group is increased, and the SOD activity is significantly reduced ( P < 0.01 ). However, aerobic exercise intervention changed those result ( P < 0.01 ). Conclusions. Aerobic exercise can relieve oxidative stress damage, lipid peroxidation levels, and chronic inflammatory status in rats with NAFLD, which can reduce NAFLD symptoms without drug dependence, and is expected to become a means of NAFLD treatment.

Comparison of the Effect of 8- and 12-Week Aerobic Exercise with Calorie Restriction on the Bax and Bcl-2 Expression in Rats with Non-alcoholic Fatty Liver Disease

“…In the NAFLD progression, hepatic steatosis is the initial factor, and inflammatory response and oxidative stress are closely associated with insulin resistance as the pathological and physiological basis of the NAFLD progression. Owing to genetic susceptibility, obesity, overweight, and other causes, the body produces insulin resistance, resulting in liver steatosis, and excessive accumulation of free fatty acid in the liver causes lipotoxicity, leading to the damage of liver cells by endoplasmic reticulum stress and oxidative stress until apoptosis (18). In the present work, the NAFLD rat model was developed by feeding rats an HFD for eight weeks.…”

“…Recently, the people in the world with NAFLD account for over 1:4 of the total population (18). Currently, due to the lack of detailed information about the underlying mechanisms of this disease, no definitive drug exists to treat NAFLD (19).…”

Retracted: Effect of Aerobic Exercise on Liver Tissue in Rats with NAFLD

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process: Discrepancies in scope Discrepancies in the description of the research reported Discrepancies between the availability of data and the research described Inappropriate citations Incoherent, meaningless and/or irrelevant content included in the article Peer-review manipulation …”

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [1]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process:…”