Potential therapeutic strategies for myocardial infarction: the role of Toll-like receptors

Komal, Sumra; Komal, Nimrah; Mujtaba, Ali; Wang, Shuhui; Zhang, Lirong; Han, Shengna

doi:10.1007/s12026-022-09290-z

Cited by 11 publications

(9 citation statements)

References 162 publications

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“… 26 Toll-like receptors have been shown to affect the progression of heart failure after myocardial infarction by mediating the release of inflammatory cytokines. 27 Calycosin has been reported to inhibit inflammation and fibrosis in rats with heart failure after myocardial infarction by activating PI3K-AKT pathway. 28 In addition, both IL-9 and IL-6, as members of the interleukin family, have been proven to be major inflammatory mediators involved in heart failure.…”

Section: Discussionmentioning

confidence: 99%

Identification of Key Immune-Related Genes in the Treatment of Heart Failure After Myocardial Infarction with Empagliflozin Based on RNA-Seq

Zhang,

Wang,

Luo

et al. 2023

JIR

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Purpose Heart failure is a serious complication after acute myocardial infarction (AMI). It is crucial to investigate the mechanism of action of empagliflozin in the treatment of heart failure. Methods A total of 20 wild type (WT) male C57BL6/J mice were used to establish a model of heart failure after myocardial infarction and randomly divided into 2 groups: treatment group and control group. The treatment group was treated with empagliflozin, and the control group was treated with placebo. After 8 weeks of treatment, mouse heart tissues were collected for next generation sequencing. Bioinformatics methods were used to screen the key genes. Finally, the correlation between clinical data and gene expression was analyzed. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to verify the expression of key genes. Results A mouse model of heart failure was successfully constructed. By DEG analysis, a total of 740 DEGs in the treatment group vs the control group were obtained. Dendritic cells, granulocytes, follicular B, plasma cell, cDC1, cDC2, pDC and neutrophils were 8 different immune cells identified by immunoinfiltration analysis. Through WGCNA, the turquoise module with the highest correlation with the above differential immune cells was selected. One hundred and forty-two immune-related DEGs were obtained by taking intersection of the DEGs and the genes of the turquoise module. Col17a1 and Gria4 were finally screened out as key immune-related genes via PPI analysis and machine learning. Col17a1 was significantly up-regulated, while Gria4 was significantly down-regulated in the treatment group. At the same time, the expression level of Col17a1 was significantly correlated with left ventricular ejection fraction (LVEF), left ventricular fraction shortening (LVFS) and left ventricular internal dimension systole (LVIDs). Conclusion Col17a1 and Gria4 are key immune-related genes of empagliflozin in the treatment of heart failure after myocardial infarction. This study provides a scientific basis for elucidating the mechanism of action of empagliflozin in treating heart failure after myocardial infarction.

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Section: Discussionmentioning

confidence: 99%

Identification of Key Immune-Related Genes in the Treatment of Heart Failure After Myocardial Infarction with Empagliflozin Based on RNA-Seq

Zhang,

Wang,

Luo

et al. 2023

JIR

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“…Komal et al (2020) functionalized cellulose nanofibers (CNFs) and modified graphene oxide (GO) using mechanical and chemical processes to remove drug species from aqueous solutions. For ciprofloxacin and ofloxacin, maximal removal capacities of 45.04 mg•g −1 and 85.30 mg•g −1 , respectively, were observed [176].…”

Section: Organic Compound Removalmentioning

confidence: 94%

Sugarcane Bagasse: Challenges and Opportunities for Waste Recycling

Hiranobe,

Gomes,

Paiva

et al. 2024

Clean Technol.

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Sugarcane has primarily been used for sugar and ethanol production. It creates large quantities of residual lignocellulosic biomass such as sugarcane bagasse, leaves, tops, and vinasse. Biomass is a sustainable prospect for biorefineries aiming to optimize production processes. We detail recent research developments in recycling sugarcane, including energy generation and pyrolysis to obtain biofuels, for example. To produce biochar, the energy cost of operating at high temperatures and large-scale production remain as obstacles. The energy generation prospects can be enhanced by pellet production; however, it requires an improvement in quality control for long-term storage or long-distance transportation. In civil construction, the materials still need to prove their long-term efficiency and reliability. Related to adsorbent materials, the use of sugarcane bagasse has the advantage of being low-cost and environmentally friendly. Nevertheless, the extraction, functionalization, and modification of cellulose fibers, to improve their adsorption properties or even mode of operation, still challenges. The synthesis of nanostructures is still lacking high yields and the ability to scale up. Finally, controlling dispersion and orientation and avoiding fiber agglomeration could improve the mechanical response of composites using sugarcane bagasse. The different possibilities for using sugarcane and its residues reinforce the importance of this material for the industry and the global economy. Thus, the present work addresses current challenges and perspectives of different industrial processes involving sugarcane aiming to support future research on waste-derived subjects.

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“…Macrophage activation produces distinct functional phenotypes that maintain homeostasis primarily by modulating the release of pro-and anti-inflammatory cytokines [ 27 ]. The M1 macrophage phenotype is activated by granulocyte-macrophage colony-stimulating factor (GM-CSF), and toll-like receptor (TLR) or IL-1R ligands and secretes pro-inflammatory cytokines, such as interleukin (IL)-1β, IL-6, IL-12, IL-23 [ 28 , 29 ], tumor necrosis factor α (TNF-α) [ 30 ], and reactive oxygen intermediates [ 31 ]. Furthermore, they express specific biomarkers, including CD86, CD83, CD80, CD68, CD40, and major histocompatibility complex class I (MHC-I) [ 32 ].…”

Section: Macrophage Heterogeneity and Functionsmentioning

confidence: 99%

Epigenetic Regulation of Macrophage Polarization in Cardiovascular Diseases

et al. 2023

Self Cite

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Cardiovascular diseases (CVDs) are the leading cause of hospitalization and death worldwide, especially in developing countries. The increased prevalence rate and mortality due to CVDs, despite the development of several approaches for prevention and treatment, are alarming trends in global health. Chronic inflammation and macrophage infiltration are key regulators of the initiation and progression of CVDs. Recent data suggest that epigenetic modifications, such as DNA methylation, posttranslational histone modifications, and RNA modifications, regulate cell development, DNA damage repair, apoptosis, immunity, calcium signaling, and aging in cardiomyocytes; and are involved in macrophage polarization and contribute significantly to cardiac disease development. Cardiac macrophages not only trigger damaging inflammatory responses during atherosclerotic plaque formation, myocardial injury, and heart failure but are also involved in tissue repair, remodeling, and regeneration. In this review, we summarize the key epigenetic modifications that influence macrophage polarization and contribute to the pathophysiology of CVDs, and highlight their potential for the development of advanced epigenetic therapies.

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Potential therapeutic strategies for myocardial infarction: the role of Toll-like receptors

Cited by 11 publications

References 162 publications

Identification of Key Immune-Related Genes in the Treatment of Heart Failure After Myocardial Infarction with Empagliflozin Based on RNA-Seq

Identification of Key Immune-Related Genes in the Treatment of Heart Failure After Myocardial Infarction with Empagliflozin Based on RNA-Seq

Sugarcane Bagasse: Challenges and Opportunities for Waste Recycling

Epigenetic Regulation of Macrophage Polarization in Cardiovascular Diseases

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