Effect of adolescent exposure to WIN 55212-2 on the acquisition and reinstatement of MDMA-induced conditioned place preference

Effects of risperidone on the acquisition and reinstatement of the conditioned place preference induced by MDMA

“…In accordance with this hypothesis, administration of 10 mg/kg of MDMA produced CPP in adolescent mice, as reported in previous studies (DazaLosada et al, 2007(DazaLosada et al, , 2009Ribeiro Do Couto et al, 2011Rodríguez-Arias et al, 2010). Our results confirm the importance of the role of DA and 5-HT 2 receptors in the acquisition of MDMAinduced CPP, since the mixed antagonist risperidone effectively blocked acquisition at a dose that did not induce motivational effects.…”

“…MDMA abuse has been documented as a result of chronic consumption (Cottler et al, 2001;Leung et al, 2010), and some ecstasy users admit becoming concerned about their use (Degenhardt et al, 2010). MDMA is self-administered by different species of experimental animals (for a review, see Schenk, 2009) and produces conditioned place preference (CPP) (Bilsky et al, 1998;Bilsky and Reid, 1991;Braida et al, 2005;Daza-Losada et al, 2007, 2009Manzanedo et al, 2010;Rodríguez-Arias et al, 2010). Dopamine (DA) and serotonin (5-HT) are involved in the rewarding effects of MDMA; the drug provokes the release of presynaptic 5-HT and, to a lesser extent, noreprinephrine and DA (Schmidt et al, 1987).…”

Abuse potential of methylenedioxymethamphetamine (MDMA) and its derivatives in zebrafish: role of serotonin 5HT2-type receptors

“…*p < 0.05, **p < 0.01, ***p < 0.001 compared with the corresponding saline group (Sal) (Fisher's exact probability test or Tukey's test). (n = 10 zebrafish for each dose) CPP in mice (Daza-Losada et al 2007;Rodríguez-Arias et al 2010;Ribeiro Do Couto et al 2012) and increased intravenous self-administration in rats (Fantegrossi et al 2013;Vandewater et al 2015). For DOB and PMA, this is the first report demonstrating their rewarding effects in animals.…”

Involvement of NMDA glutamate receptors in the acquisition and reinstatement of the conditioned place preference induced by MDMA

“…Control groups were injected with the physiological saline in which the drugs were dissolved (0.9% NaCl). The doses were selected on the basis of previous studies on MDMA (Daza-Losada et al, 2007Manzanedo et al, 2010;Rodríguez-Arias et al, 2010;Vidal-Infer et al, 2012) and memantine (Ribeiro Do Couto et al, 2004;Ribeiro Do Couto et al, 2005;Maldonado et al, 2007).…”