Effect of acute and chronic eccentric exercise on FOXO1 mRNA expression as fiber type transition factor in rat skeletal muscles

azad, milad; Khaledi, Neda; Hedayati, Mehdi

doi:10.1016/j.gene.2016.02.033

Cited by 20 publications

(13 citation statements)

References 35 publications

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“…To maintain the human body’s muscle volume, prolonged resistance training is required 7. Moreover, exercise can raise the efficiency of muscular glucose uptake because of an increase in muscle forkhead box protein O18 and glucose transporter 4,9 which controls blood glucose levels 10. These rules are also applicable to patients with type 2 diabetes 9.…”

Section: Introductionmentioning

confidence: 99%

Japanese radio calisthenics prevents the reduction of skeletal muscle mass volume in people with type 2 diabetes

Kimura

Okamura

Iwai

et al. 2020

BMJ Open Diab Res Care

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ObjectiveReduction of muscle mass and strength is an important treatment target for patients with type 2 diabetes. Recent studies have reported that high-intensity resistance training improves physical function; however, all patients found it difficult to perform high-intensity resistance training. Radio calisthenics, considered as therapeutic exercises to promote health in Japan, are simple exercises that can be performed regardless of age and help move the muscles and joints of the whole body effectively according to the rhythm of radio. We investigated the efficacy of radio calisthenics for muscle mass in patients with type 2 diabetes in this retrospective cohort study.Research design and methodsA total of 42 hospitalized patients with type 2 diabetes were recruited. The skeletal muscle mass index (SMI, kg/m2) was calculated as appendicular muscle mass (kg) divided by height squared (m2). We defined the change of SMI as the difference of SMI between the beginning and end of hospitalization.ResultsAmong 42 patients, 15 (11 men and 4 women) performed radio calisthenics. Body weights of both radio calisthenics exercisers and non-exercisers decreased during hospitalization. The change of SMI was significantly lesser in radio calisthenics exercisers than in non-exercisers (7.1±1.4 to 7.1±1.3, –0.01±0.09 vs 6.8±1.1 to 6.5±1.2, –0.27±0.06 kg/m2, p=0.016). The proportion of decreased SMI was 85.2% (23/27 patients) in non-radio calisthenics exercisers, whereas that in radio calisthenics exercisers was 46.7% (7/15 patients).ConclusionsRadio calisthenics prevent the reduction of skeletal muscle mass. Thus, radio calisthenics can be considered effective for patients with type 2 diabetes.

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Section: Introductionmentioning

confidence: 99%

Japanese radio calisthenics prevents the reduction of skeletal muscle mass volume in people with type 2 diabetes

Kimura

Okamura

Iwai

et al. 2020

BMJ Open Diab Res Care

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“…The present study confirmed that melon concentrate was able to induce an increase in PGC-1α plasma level. PGC-1α is well known to stimulate mitochondrial biogenesis, but also to promote the remodeling of muscle tissue by modulating fiber-type composition [41][42][43]. Interestingly, the study evidenced that the supplementation tended to induce a decrease in fast-twitch myosin fibers and an increase in slow-twitch myosin fibers following the eccentric exercise.…”

Section: Discussionmentioning

confidence: 85%

Supplementation with a Bioactive Melon Concentrate in Humans and Animals: Prevention of Oxidative Damages and Fatigue in the Context of a Moderate or Eccentric Physical Activity

Saby

Gauthier²,

Barial

et al. 2020

IJERPH

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Exercise is recognized to provide both physical and psychological health benefits. However, oxidative stress can occur and induce muscular damages. SOD B ® M is a melon concentrate, well known to counteract oxidative stress and prevent its side effects. The present study aimed to evaluate the potential of the melon concentrate in the context of both a strong and isolated effort associated with deleterious effects, and a moderate and regular physical activity considered as beneficial. First, a preclinical study was set up on rats to evaluate its potential on the prevention of damages induced by an eccentric exercise. Secondly, the combined effect of the melon concentrate and a regular standardized physical training was studied on the overall physical condition of healthy subjects in a randomized, double-blind, placebo-controlled trial. Repeated measures Analysis of Variance (ANOVA), student's t test and Mann-Whitney test were used for statistical analyses. Melon concentrate helped to prevent gastrocnemius damages induced by the eccentric exercise. It allowed a reduction of fibrosis by approximately 38% and a reduction of Tumor Necrosis Factor-α (TNF-α) plasma level by 28%. This supplementation also induced a rearrangement of myosin fibers and an increase in PGC-1α plasma level. In the clinical study, melon concentrate was able to decrease oxidative stress and C-Reactive protein (CRP) plasma level. Besides, magnesium (Mg) plasma level was higher in the context of a regular training performed by healthy subjects supplemented with the melon concentrate. Therefore, the melon concentrate allowed a better adaptation to effort linked to PGC-1α activation: a regulator of energy metabolism. The antioxidant properties of the melon concentrate and its ability to mobilize magnesium also suggest that the supplementation could induce a better resistance to fatigue and recovery during regular physical activity.

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“…The study also found that melon concentrate was able to induce an increase in PGC-1α plasma level. As a key regulator of energy metabolism, PGC-1α is well known to stimulate mitochondrial biogenesis, but also to promote the remodeling of muscle tissue by modulating fiber-type composition (35)(36)(37). Interestingly, the study evidenced that the supplementation tended to induce a decrease in fast-twitch myosin fibers and an increase in slow-twitch myosin fibers following the eccentric exercise.…”

Section: Discussionmentioning

confidence: 91%

Supplementation with a bioactive melon concentrate in humans and animals: prevention of oxidative damages and fatigue in the context of a moderate or eccentric physical activity

Saby

Gauthier²,

Barial

et al. 2019

Preprint

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Background: Physical activity is recognized to provide both physical and psychological health benefits. However, oxidative stress can occur in case of poor adaptation to effort and reduce training effectiveness inducing muscular and joint damages. SOD B® M is a melon concentrate, well known to counteract oxidative stress and prevent its side effects. The present study aimed to evaluate the potential of the melon concentrate in the context of both a strong and isolated effort associated with deleterious effects, and a moderate and regular physical activity considered as beneficial. Methods: First, a preclinical study was set up on Sprague Dawley rats to evaluate the effect of the melon concentrate on the prevention of damages induced by an eccentric exercise. Secondly, the combined effect of the melon concentrate and a regular standardized physical training was studied on the overall physical condition of healthy subjects in a randomized, double-blind, placebo-controlled trial. Repeated measures ANOVA, student’s t test and Mann-Whitney test were used for statistical analyses. Results: Melon concentrate helped to prevent gastrocnemius damages induced by the eccentric exercise. It allowed a reduction of fibrosis by approximately 38 % and a reduction of TNF-α plasma level by 28 %. This supplementation also induced a rearrangement of myosin fibers and an increase in PGC-1α plasma level. In the clinical study, melon concentrate was able to decrease oxidative stress and CRP plasma level. Besides, magnesium (Mg) plasma level was higher in the context of a regular training performed by healthy subjects supplemented with the melon concentrate. Conclusions: Melon concentrate was able to prevent damages generated during an eccentric exercise. It also allowed a better adaptation to effort linked to PGC-1α activation: a regulator of energy metabolism. The antioxidant properties of the melon concentrate and its ability to mobilize Mg also suggest that the supplementation could induce a better endurance and resistance to fatigue during regular physical activity.

show abstract

Effect of acute and chronic eccentric exercise on FOXO1 mRNA expression as fiber type transition factor in rat skeletal muscles

Cited by 20 publications

References 35 publications

Japanese radio calisthenics prevents the reduction of skeletal muscle mass volume in people with type 2 diabetes

Japanese radio calisthenics prevents the reduction of skeletal muscle mass volume in people with type 2 diabetes

Supplementation with a Bioactive Melon Concentrate in Humans and Animals: Prevention of Oxidative Damages and Fatigue in the Context of a Moderate or Eccentric Physical Activity

Supplementation with a bioactive melon concentrate in humans and animals: prevention of oxidative damages and fatigue in the context of a moderate or eccentric physical activity

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