Supplementation with a Bioactive Melon Concentrate in Humans and Animals: Prevention of Oxidative Damages and Fatigue in the Context of a Moderate or Eccentric Physical Activity

Abstract

Exercise is recognized to provide both physical and psychological health benefits. However, oxidative stress can occur and induce muscular damages. SOD B ® M is a melon concentrate, well known to counteract oxidative stress and prevent its side effects. The present study aimed to evaluate the potential of the melon concentrate in the context of both a strong and isolated effort associated with deleterious effects, and a moderate and regular physical activity considered as beneficial. First, a preclinical study was set up on rats to evaluate its potential on the prevention of damages induced by an eccentric exercise. Secondly, the combined effect of the melon concentrate and a regular standardized physical training was studied on the overall physical condition of healthy subjects in a randomized, double-blind, placebo-controlled trial. Repeated measures Analysis of Variance (ANOVA), student's t test and Mann-Whitney test were used for statistical analyses. Melon concentrate helped to prevent gastrocnemius damages induced by the eccentric exercise. It allowed a reduction of fibrosis by approximately 38% and a reduction of Tumor Necrosis Factor-α (TNF-α) plasma level by 28%. This supplementation also induced a rearrangement of myosin fibers and an increase in PGC-1α plasma level. In the clinical study, melon concentrate was able to decrease oxidative stress and C-Reactive protein (CRP) plasma level. Besides, magnesium (Mg) plasma level was higher in the context of a regular training performed by healthy subjects supplemented with the melon concentrate. Therefore, the melon concentrate allowed a better adaptation to effort linked to PGC-1α activation: a regulator of energy metabolism. The antioxidant properties of the melon concentrate and its ability to mobilize magnesium also suggest that the supplementation could induce a better resistance to fatigue and recovery during regular physical activity.

Superoxide Dismutase Administration: A Review of Proposed Human Uses

“…The study demonstrated a lower initial inflammatory state in the SODB group which was maintained during and after the training session, whereas the placebo group experienced a significant increase in inflammation. The authors identified an increase in the PARγ coactivator 1-alpha (PGC-1alpha) and the consequent myosin fibers rearrangement the lading pathway for adaptation to effort, endurance, performance [ 179 ].…”

Natural Antioxidant Potential of Melon Peels for Fortified Foods

“…During the last decade, efforts to valorize food by-products have increased demands for testing different extraction techniques to isolate beneficial enzymes, for instance, from melon pulp and juice. In this context, it was demonstrated that the oral daily intake of melon juice rich in SOD helps to reduce symptoms of body stress and fatigue [ 18 , 19 ]. In the human body, defenses against free radicals are due to the synergic actions of the inner SOD and CAT antioxidant enzymes.…”

“…In the human body, defenses against free radicals are due to the synergic actions of the inner SOD and CAT antioxidant enzymes. Since their finding, many studies have been published, and recently, the efficacy of melon’s SOD supply in controlled clinical studies has proven how the SOD provides preventive and restorative effects from oxidative stress and gives inflammation relief in almost all tissues [ 18 ].…”

“…To the best of our knowledge, studies about oxidative and degradative activities have never been conducted on cantaloupe peels [ 5 , 17 ], despite several patented active supplements from melon pulp and juice that have been developed recently. SOD B Dimpless ® and Extramel ® are nutraceutical products based on natural extracts of melons, to mention some of them currently on sale, and containing active superoxide dismutase that claim a list of health benefits [ 18 , 19 ].…”

Дынный Сок: 7 Полезных Свойств Для Организма

“…Напиток предупреждает окислительный стресс икроножных мышц вследствие их перегрузки, что позволяет людям, занимающимся спортом и прочей физической активностью, быстрее восстанавливаться после полученных нагрузок, меньше уставать. [16]…”