Superoxide Dismutase Administration: A Review of Proposed Human Uses

Rosa, Arianna Carolina; Corsi, Daniele; Cavi, Niccolò; Bruni, Natascia; Dosio, Franco

doi:10.3390/molecules26071844

Cited by 107 publications

(96 citation statements)

References 315 publications

(395 reference statements)

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“…The possible mechanism may be that the metabolic rate of brain tissues and cell energy are slowed down under mild hypothermia, which reduces neuron necrosis and apoptosis [ 23 ]. While low temperature environment alone cannot restore the damaged nerve cells, GM1, as an essential substance for the regeneration and development of brain nerves, can promote nerve regeneration [ 24 ], which makes up for the shortcomings of mild hypothermia therapy. In combination, the two treatments complement each other to achieve better curative effects.…”

Section: Discussionmentioning

confidence: 99%

Neural Function Recovery and Safety of Mild Hypothermia Therapy Combined with Monosialotetrahexosylganglioside on Neonatal Asphyxia Complicated by Hypoxic Ischemic Encephalopathy

Jiao

et al. 2021

Computational and Mathematical Methods in Medicine

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Objective. To explore the effect and safety of mild hypothermia therapy combined with monosialotetrahexosylganglioside (GM1) on neural function recovery of neonatal asphyxia complicated by hypoxic ischemic encephalopathy (HIE). Methods. The clinical data of 90 neonates with HIE were retrospectively analyzed. According to the treatment methods, the neonates were divided into a routine group, a mild hypothermia group, and a combination group, with 30 cases in each group. The differences in neural function recovery, biochemical indexes, clinical signs recovery, efficacy, and complications were observed in the three groups after treatment. Results. After treatment, the score of neonatal behavioral neurological assessment (NBNA) and level of superoxide dismutase (SOD) in the combination group were higher than those of the other two groups ( P < 0.05 ). The levels of neuron-specific enolase (NSE), S-100β protein, and plasma neuropeptide Y (NPY) in the combination group were lower than those in the other two groups, and the recovery time of consciousness, muscle tension, and reflex was shorter ( P < 0.05 ). The combination group showed higher total effective rate and lower incidence of complications as compared with the other two groups ( P < 0.05 ). Conclusion. Mild hypothermia therapy combined with GM1 for the treatment of neonatal asphyxia complicated by HIE can promote the recovery of neural function and reduce the incidence of complications in neonates.

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Section: Discussionmentioning

confidence: 99%

Neural Function Recovery and Safety of Mild Hypothermia Therapy Combined with Monosialotetrahexosylganglioside on Neonatal Asphyxia Complicated by Hypoxic Ischemic Encephalopathy

Jiao

et al. 2021

Computational and Mathematical Methods in Medicine

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“…It is a superoxide dismutase mimetic compound, derivative of the magnetic resonance imaging contrast agent mangafodipir and containing approximate calcium to manganese molar ratio of 4:1 (Karlsson et al, 2015). It mediates the protection of liver cells from oxidative stress generated by high doses of paracetamol, especially in the late stages (Jaeschke et al, 2020;Mullins et al, 2020;Rosa et al, 2021).…”

Section: Calmangafodipirmentioning

confidence: 99%

Novel Therapies for the Treatment of Drug-Induced Liver Injury: A Systematic Review

et al. 2022

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Many drugs with different mechanisms of action and indications available on the market today are capable of inducing hepatotoxicity. Drug-induced liver injury (DILI) has been a treatment challenge nowadays as it was in the past. We searched Medline (via PubMed), CENTRAL, Science Citation Index Expanded, clinical trials registries and databases of DILI and hepatotoxicity up to 2021 for novel therapies for the management of adult patients with DILI based on the combination of three main search terms: 1) treatment, 2) novel, and 3) drug-induced liver injury. The mechanism of action of novel therapies, the potential of their benefit in clinical settings, and adverse drug reactions related to novel therapies were extracted. Cochrane Risk of bias tool and Grading of Recommendations Assessment, Development and Evaluation (GRADE) assessment approach was involved in the assessment of the certainty of the evidence for primary outcomes of included studies. One thousand three hundred seventy-two articles were identified. Twenty-eight articles were included in the final analysis. Eight randomized controlled trials (RCTs) were detected and for six the available data were sufficient for analysis. In abstract form only we found six studies which were also anaylzed. Investigated agents included: bicyclol, calmangafodipir, cytisin amidophospate, fomepizole, livina-polyherbal preparation, magnesium isoglycyrrhizinate (MgIG), picroliv, plasma exchange, radix Paeoniae Rubra, and S-adenosylmethionine. The primary outcomes of included trials mainly included laboratory markers improvement. Based on the moderate-certainty evidence, more patients treated with MgIG experienced alanine aminotransferase (ALT) normalization compared to placebo. Low-certainty evidence suggests that bicyclol treatment leads to a reduction of ALT levels compared to phosphatidylcholine. For the remaining eight interventions, the certainty of the evidence for primary outcomes was assessed as very low and we are very uncertain in any estimate of effect. More effort should be involved to investigate the novel treatment of DILI. Well-designed RCTs with appropriate sample sizes, comparable groups and precise, not only surrogate outcomes are urgently welcome.

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“…Certain nitroxides are also showing promising results in conferring radioprotection in animal model. Tempol is a nitroxide which is SOD mimetic and acts as free radical scavenger (Rosa et al, 2021). Vitamin A, C, E, K being antioxidants can effectively scavenge free radical induced by ionizing radiation.…”

Section: Synthetic Radioprotectorsmentioning

confidence: 99%

Herbal Radioprotectors: A mini-review of the Current Status

Haritwal¹,

Tiwari²,

Agrawala³

2022

NRFHH

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Because of our increased dependency on the use of radiation in areas such as the food industry, agriculture, space exploration, diagnostics and treatment of various diseases including cancer, the possibilities of unnecessary exposure to ionizing radiation have considerably increased. Hence, there is a need to develop an effective radioprotective agent that can protect against the deleterious effects of ionizing radiation. So far, many synthetic and natural substances studied for use as radioprotectors have failed to reach clinics. Natural compounds are becoming more popular in radiation research due to their low toxicity, higher efficacy and cost-effectiveness. Plants and herbs contain a plethora of bioactive compounds having antioxidants, anti-inflammatory and immunostimulant properties which can act either in isolation or in combination to protect against the harmful effects of ionizing radiation This review mainly focuses on the radioprotective potential of various herbs and plants. The results obtained from various herbal extracts have shown protection against radiation-induced injuries in preclinical studies. This evaluation may help develop a potent radioprotector of desired efficacy.

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Superoxide Dismutase Administration: A Review of Proposed Human Uses

Cited by 107 publications

References 315 publications

Neural Function Recovery and Safety of Mild Hypothermia Therapy Combined with Monosialotetrahexosylganglioside on Neonatal Asphyxia Complicated by Hypoxic Ischemic Encephalopathy

Neural Function Recovery and Safety of Mild Hypothermia Therapy Combined with Monosialotetrahexosylganglioside on Neonatal Asphyxia Complicated by Hypoxic Ischemic Encephalopathy

Novel Therapies for the Treatment of Drug-Induced Liver Injury: A Systematic Review

Herbal Radioprotectors: A mini-review of the Current Status

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