Effect of acepromazine, butorphanol, or N-butylscopolammonium bromide on visceral and somatic nociception and duodenal motility in conscious horses

Sanchez, L. Chris; Elfenbein, Johanna R.; Robertson, Sheilah A.

doi:10.2460/ajvr.69.5.579

Cited by 47 publications

(50 citation statements)

References 34 publications

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“…However, Grint and others (2014) reported mean MNT values of 9.2 N using a rate of application of force of 0.4 N/second in donkeys. The difference in basal MNT values between studies may be due to the use of different actuators as it has been demonstrated in horses (Taylor and others 2012). …”

Section: Discussionmentioning

confidence: 99%

Sedation and mechanical antinociception after intravenous administration of detomidine in donkeys: a dosage–effect study

et al. 2015

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There is limited, useful, scientific information on detomidine in donkeys. This study compared the effects of intravenous saline, detomidine (10, 13.5, 17 and 20 μg/kg) and acepromazine (50 μg/kg) in donkeys by computing areas under the curve for 0-30, 30-60 and 60-120 minutes (AUC0-30, AUC30-60 and AUC60-120) for sedation scores, head heights and mechanical nociceptive thresholds (MNTs). For sedation scores, all detomidine treatments, except 10 μg/kg, increased AUC0-30 values compared with saline, and AUC0-30 values were larger for 17 μg/kg detomidine than for acepromazine. All head height AUC values were lower for detomidine than for saline (except AUC60-120 for 10 μg/kg detomidine) and acepromazine (except AUC0-30 for 10 and 20 μg/kg detomidine, and AUC60-120 for 10 μg/kg detomidine). For MNTs, all detomidine treatments increased AUC0-30 and AUC30-60 values compared with saline and acepromazine; AUC30-60 values were smaller for 10 μg/kg than for 17 and 20 μg/kg detomidine. MNT AUC60-120 values were larger for 20 μg/kg detomidine than for saline, 10 μg/kg detomidine and acepromazine. Detomidine induced sedation and antinociception, but only antinociception was dosage dependent. Selection of detomidine dosage for donkeys may depend on the required duration of sedation and/or degree of analgesia.

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Section: Discussionmentioning

confidence: 99%

Sedation and mechanical antinociception after intravenous administration of detomidine in donkeys: a dosage–effect study

et al. 2015

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“…Alternatively, it is possible that affected horses experienced some degree of analgesia thus continued to eat hay despite developing ileus, until a more severe problem developed. In prior studies, we were unable to demonstrate visceral anti-nociceptive effects with lidocaine [10] or butorphanol [13] administered as a CRI to healthy horses. It is not known whether anti-nociceptive properties would exist with this drug combination in ill or painful horses.…”

Section: Discussionmentioning

confidence: 99%

“…This supports prior work in healthy horses [20] and horses post-celiotomy [14], which also showed decreased fecal output. But, in healthy horses, a short duration butorphanol CRI did not significantly alter duodenal motility [13]. The observed decrease in fecal weight and prolonged passage of beads for combinations that included butorphanol may be due to numerous factors including the potential for accumulation of any drug or its metabolites during the infusion, competitive metabolism, or a potential synergistic inhibitory effect on motility of drugs given in combination.…”

Section: Discussionmentioning

confidence: 99%

“…The opioid drug butorphanol, a kappa (OP2) agonist and competitive mu (OP3) antagonist, is commonly administered in the horse with varying success. No anti-nociceptive properties were noted in clinically normal horses in response to visceral distension or noxious thermal stimulus [13] but pain scores were significantly decreased in horses administered butorphanol as a constant rate infusion in the immediate post-operative period following exploratory laparotomy [14]. …”

Section: Introductionmentioning

confidence: 99%

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Systemic and anti-nociceptive effects of prolonged lidocaine, ketamine, and butorphanol infusions alone and in combination in healthy horses

et al. 2014

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BackgroundProlonged drug infusions are used to treat horses with severe signs of pain, but can be associated with altered gastrointestinal transit. The purpose of this study was to determine the effects of prolonged constant rate infusions (CRI) of lidocaine (L), butorphanol (B), and ketamine (K) alone and in combination on gastrointestinal transit, behavior, and thermal nociceptive threshold in healthy horses.MethodsEight healthy adult horses were used in a randomized, cross-over, blinded, prospective experimental trial. Interventions were saline, L, K, B, LK, LB, BK, and LBK as an intravenous CRI for 96 hours. Drugs were mixed or diluted in saline; following a bolus, CRI rate was 0.15mL/kg/hr with drug doses as follows: L – 1.3 mg/kg then 3 mg/kg/hr; B – 0.018 mg/kg then 0.013 mg/kg/hr; K – 0.55 mg/kg then 0.5 mg/kg/hr. Two-hundred plastic beads were administered intragastrically by nasogastric tube immediately prior to the bolus. Feces were collected every 2 hours, weighed, and beads manually retrieved. Behavior was scored every 2 hours, vital parameters every 6 hours, and thermal nociceptive threshold every 12 hours for 96 hours. Drug concentrations in the LBK solution were tested every 6 hours for 72 hours.ResultsFour of 64 trials (3 LBK, 1 BK) were discontinued early due to signs of abdominal discomfort. There were no apparent differences between groups in vital parameters or thermal threshold. Transit time was delayed for LB and LBK with a corresponding decrease in fecal weight that was most severe in the final 24 hours of infusion. Significant changes in behavior scores, vital parameters, or thermal threshold were not observed. The concentration of each drug in the combined solution declined by less than 31% over the sampling period.ConclusionsDrug combinations containing butorphanol cause an apparent delay in gastrointestinal transit in healthy horses without substantially affecting somatic nociception at the doses studied. Combinations of lidocaine and ketamine may have less impact on gastrointestinal transit than infusions combined with butorphanol. Further work is needed to determine the effects of these drugs in painful or critically ill patients.

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“…Sanchez et al 17 the dose of 18 µg kg -1 , but not after infusion at the rate of 13 µg kg -1 hour -1 for 2 hours. The same observations were reported by Sellon et al 8 using doses of 0.13 mg kg -1 as a bolus, followed by a continuous rate infusion of 13 µg kg -1 hour -1 for 24 hours.…”

Section: Discussionmentioning

confidence: 99%

Effects of a continuous rate infusion of butorphanol in isoflurane-anesthetized horses on cardiorespiratory parameters, recovery quality, gastrointestinal motility and serum cortisol concentrations

et al. 2014

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Conception, design, intellectual and scientific content of the study; statistical analysis. ABSTRACT PURPOSE:To assess the cardiorespiratory parametes, recovery, gastrointestinal motility and serum cortisol concentrations in horses anesthetized with isoflurane with or without a continuous rate infusion (CRI) of butorphanol for orchiectomy. METHODS:Twelve adult, intact, male horses weighing 332 ± 55 kg were included in the study. Xilazine was administered as premedication. Anesthesia was induced with ketamine and midazolam and maintained with isoflurane. Butorphanol (0.025 mg kg -1 bolus) or an equivalent volume of saline (0.9%) was given intravenously followed by a CRI of butorphanol (BG) (13 µg kg -1 hour -1 ) or saline (CG). Cardiorespiratory variables were recorded before (T0) and every 15 minutes for 75 minutes after the start of infusion.Serum cortisol concentration was measured at T0 and 60 minutes, and 30 minutes and 19 hours after the horse stood up. Recovery from anesthesia was evaluated using a scoring system. Gastrointestinal motility was evaluated before anesthesia and during 24 hours after recovery. RESULTS:There were no significant differences between groups in cardiopulmonary variables, or recovery scores or serum cortisol concentrations. A reduction in gastrointestinal motility was recorded for 60 minutes in BG. CONCLUSIONS:Continuous rate infusion of butorphanol in horses anesthetized with isoflurane did not adversely affect the cardiopulmonary variables monitored, or recovery scores. A small but statistically significant reduction in gastrointestinal motility occurred in the butorphanol group.

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Effect of acepromazine, butorphanol, or N-butylscopolammonium bromide on visceral and somatic nociception and duodenal motility in conscious horses

Abstract: Each drug caused predictable changes in sedation and vital signs, but consistent anti-nociceptive effects were not evident.

Cited by 47 publications

References 34 publications

Sedation and mechanical antinociception after intravenous administration of detomidine in donkeys: a dosage–effect study

Sedation and mechanical antinociception after intravenous administration of detomidine in donkeys: a dosage–effect study

Systemic and anti-nociceptive effects of prolonged lidocaine, ketamine, and butorphanol infusions alone and in combination in healthy horses

Effects of a continuous rate infusion of butorphanol in isoflurane-anesthetized horses on cardiorespiratory parameters, recovery quality, gastrointestinal motility and serum cortisol concentrations

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