Effect of a Symbiotic Gel (Lactobacillus acidophilus + Bifidobacterium lactis + Inulin) on Presence and Severity of Gastrointestinal Symptoms in Hemodialysis Patients

Hörner, Daniela Viramontes; Márquez‐Sandoval, Fabiola; Martín-del-Campo, Fabiola; Vizmanos-Lamotte, Barbara; Sandoval-Rodríguez, Ana; Armendáriz‐Borunda, Juan; García-Bejarano, Hector; Renoirte-Lopez, Karina; García-García, Guillermo

doi:10.1053/j.jrn.2014.09.008

Cited by 58 publications

(71 citation statements)

References 27 publications

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“…The subgroup analysis of two studies on non‐dialysis patients displayed that probiotic supplements significantly reduced urea (MD = −30.01; 95% CI = [−56.78, −3.25]; P = 0.03), with high heterogeneity ( P = 0.08; I 2 = 68%). In the four studies, on dialysis patients, the subgroup analysis exhibited no significant difference between probiotics and placebo (MD = 0.1; 95% CI = [−9.28, 9.48], P = 0.98), with no heterogeneity ( P = 0.65, I 2 = 0%) (Fig. ).…”

Section: Resultsmentioning

confidence: 99%

“…In addition, the risk of bias of each included study was shown in Table . One of the 10 studies was at a high risk of bias, 4 studies were at a low risk of bias, and the other 5 studies were at an unclear risk of bias according to the Cochrane Collaboration's assessment. The funnel plots of each outcome (Appendix S4) and the Egger's test (urea: P = 0.293, uric acid: P = 0.659, CRP: P = 0.770, creatinine: P = 0.686, eGFR: P = 0.051) showed no evidence of publication bias.…”

Section: Resultsmentioning

confidence: 99%

“…In the meta‐analysis, six of the included studies reported the changes in serum creatinine level. Heterogeneity of the six studies was significant ( P = 0.006, I 2 = 69%).…”

Section: Resultsmentioning

confidence: 99%

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Effects of probiotic supplements on the progression of chronic kidney disease: A meta‐analysis

et al. 2019

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Background Chronic kidney disease (CKD) is a worldwide public health problem. Although accumulated data suggested that probiotic supplements played roles in CKD, the results remained controversial. Here, we performed a meta‐analysis to assess the effects of probiotic supplements on the CKD progression. Methods A systematic search was conducted through the PubMed, Embase and Cochrane databases until September 2018. Randomized controlled trials with control receiving placebo, evaluating the effects of probiotic supplements on CKD were included. Results A total of 10 randomized controlled trials in 8 countries were selected. In the meta‐analysis, urea level was significantly reduced in probiotics‐administrated non‐dialysis patients (mean differences (MD) = −30.01; 95% confidence interval (CI) = [−56.78, −3.25]; P = 0.03) while no significant change was found in the dialysis patients receiving probiotics (MD = 0.1; 95% CI = [−9.28, 9.48]; P = 0.98). Probiotic supplements also exhibited no effect on uric acid (MD = −0.43; 95% CI = [−1.19, 0.33]; P = 0.27), C‐reactive protein (MD = −0.48; 95% CI = [−1.29, 0.33]; P = 0.24), creatinine (MD = −0.18; 95% CI = [−0.82, 0.47]; P = 0.59), and estimated glomerular filtration rate (MD = 2.10; 95% CI = [−1.31, 5.52]; P = 0.23) of CKD patients. Conclusion Our results highlighted that probiotic supplements exerted a statistically significant effect on urea levels in non‐dialysis CKD population, while no evidence suggested that probiotics possessed meaningful impacts on the reduction of uric acid, C‐reactive protein, creatinine and estimated glomerular filtration rate preservation of CKD population.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Effects of probiotic supplements on the progression of chronic kidney disease: A meta‐analysis

et al. 2019

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“…Other tools used included nonvalidated patient administered questionnaires and the Rome II (for functional bowel disorders) and Rome III (for IBS) criteria. Other methods of diagnosis included an interview process, GSQ, laboratory stool analysis, Izumo Scale, 34 Bristol Stool Chart, 35 an unspecified validated Table 4 The prevalence of gastrointestinal (GI) symptoms in haemodialysis (HD) and peritoneal dialysis (PD) patients, reported across the 11 studies with a Newcastle Ottawa Scale (NOS) score greater than five 5,[11][12][13][21][22][23][24]26,27,31…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal symptoms in patients receiving dialysis: A systematic review

et al. 2018

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“…sí observaron mejorías en la sintomatología gastrointestinal en 21 pacientes en hemodiálisis, sin observar cambios significativos en marcadores inflamatorios, tras 2 meses de suplementación con un producto que contenía L. acidophilus y B. animalis subesp. lactis, 2,3g de inulina y 1,5g de omega-3 47 . Este mismo grupo de trabajo reportó cambios en la composición de la microbiota intestinal, con incrementos en la cuenta de bifidobacterias tras 2 meses de suplementación del mismo producto en 18 pacientes en terapia hemodiálisis 48 .…”

Section: Estrategias Terapéuticasunclassified

Alteraciones en el eje intestino-riñón durante la enfermedad renal crónica: causas, consecuencias y propuestas de tratamiento

Osuna-Padilla

Leal-Escobar

2017

Rev Esp Nutr Hum Diet

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La enfermedad renal crónica y el estado urémico se asocian con alteraciones en la permeabilidad intestinal y cambios en la microbiota intestinal, provocando una mayor producción y translocación de toxinas urémicas como sulfato de indoxilo (IS) y sulfato de p-cresilo (pCS), detonando una respuesta inflamatoria. El estado inflamatorio y el incremento en concentraciones séricas de IS y pCS se han asociado con una mayor mortalidad, mayor número de eventos cardiovasculares y mayores alteraciones en el metabolismo mineral y óseo. Se han estudiado diversas estrategias nutricionales y farmacológicas para modular la microbiota intestinal y mejorar las alteraciones en la permeabilidad intestinal, entre ellas la suplementación con probióticos, prebióticos y simbióticos, modificaciones en la composición de la dieta y uso de agentes adsorbentes. El objetivo del presente trabajo es realizar una revisión de las causas de las alteraciones intestinales y de la microbiota intestinal en el paciente con enfermedad renal crónica, analizando las consecuencias de dichos cambios y las intervenciones estudiadas hasta la actualidad. PALABRAS CLAVE R E S U M E NAlteraciones en el eje intestino-riñón durante la enfermedad renal crónica: causas, consecuencias y propuestas de tratamiento

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Effect of a Symbiotic Gel (Lactobacillus acidophilus + Bifidobacterium lactis + Inulin) on Presence and Severity of Gastrointestinal Symptoms in Hemodialysis Patients

Cited by 58 publications

References 27 publications

Effects of probiotic supplements on the progression of chronic kidney disease: A meta‐analysis

Effects of probiotic supplements on the progression of chronic kidney disease: A meta‐analysis

Gastrointestinal symptoms in patients receiving dialysis: A systematic review

Alteraciones en el eje intestino-riñón durante la enfermedad renal crónica: causas, consecuencias y propuestas de tratamiento

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