Effect of a partial-feeding application on product purities and throughput of a five-zone simulated moving bed process for the separation of a ternary nucleoside mixture

Mun, Sungyong

doi:10.1016/j.procbio.2011.01.015

Cited by 13 publications

(5 citation statements)

References 20 publications

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“…Furthermore, the area of operating conditions satisfying the constraint of ≥98% product purity (denoted by the blue and yellow squares) was obviously small compared to the area within the whole theoretical triangle region of 100% purity of products. This was owing to the contributions of mass transfer resistance and dispersion effects 17 . In order to overcome the drawback of low productivity due to the low feed flow rate, as occurred in the full feed scenario, the three partial feed strategies (illustrated above in the section on ‘Partial feed strategy for the three‐zone SMB’) were then applied to each operating point located in the triangle diagram.…”

Section: Resultsmentioning

confidence: 99%

“…The effect of partial feed strategy on the performance of three‐zone SMB was investigated for four different feed patterns: full feed and partial feed, 17,32 with the latter divided into three categories as initial feed (IF), middle feed (MF) and late feed (LF). Two parameters – feed flow rate and feed loading time – were considered.…”

Section: Methodsmentioning

confidence: 99%

“…This situation leads to the applications of non‐conventional operation of SMB. For example, the strategy of partial feeding was used to increase the throughput of a five‐zone SMB process for the isolation of nucleoside mixture 17 and a three‐zone SMB for lactic–succinic separation 18 . Another drawback of low feed flow rate employed to achieve high purity in the case of low selectivity of separation is the highly diluted product, especially in the raffinate product of a three‐zone SMB.…”

Section: Introductionmentioning

confidence: 99%

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Enhanced separation of chlorogenic and gallic acids extracted from spent coffee grounds using a three‐zone simulated moving bed process with partial feed and partial collection strategies

Tangpromphan

Nakkong

Jaree

2021

J of Chemical Tech & Biotech

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BACKGROUND Spent coffee grounds, a valuable source of phenolic compounds, are considered beneficial for human health because of their antioxidative properties. The liquid extract containing phenolic compounds (such as chlorogenic and gallic acids) can be obtained via extraction using environmentally friendly organic solvent. The separation of chlorogenic and gallic acids from the liquid extract was carried out using isocratic chromatography technique in a three‐zone simulated moving bed (SMB). However, due to the low selectivity of separation, the productivity of three‐zone SMB was sacrificed to meet the purity criteria. Hence this work aimed to enhance the productivity of three‐zone SMB for the separation of chlorogenic and gallic acids via model simulation using partial feed operation and to improve the concentration of extract and raffinate products using partial collection strategy. RESULTS The full feed scenario was designed based on the triangle theory, and the partial feed patterns (initial feed, middle feed and late feed) were implemented for each operating point in the triangle diagram to investigate the possibility of increasing the feed flow rate. The maximum productivity was evaluated based on the purity criteria (≥98%) for both extract and raffinate products. Under optimal conditions, productivity was doubled to 0.24 mg min−1 L−1 for both middle feed and late feed patterns compared to that of the full feed scenario. The partial collection strategy applied to the optimal point for each operational mode significantly increased the raffinate concentration to approximately 0.02 g L−1 at the optimal time fraction for discarding the solvent. CONCLUSION This work could be a foundation for the valorization of spent coffee ground. © 2021 Society of Chemical Industry (SCI).

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Enhanced separation of chlorogenic and gallic acids extracted from spent coffee grounds using a three‐zone simulated moving bed process with partial feed and partial collection strategies

Tangpromphan

Nakkong

Jaree

2021

J of Chemical Tech & Biotech

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“…21,22 The JO process was discussed in detail in the section of JO-IEX operation scheme. Furthermore, some other strategies including three-zone SMB, 23 five-zone SMB, 24 gradient elution, 25 and partial injection 26 have been proposed for the separation of multiple components. However, the above processes were mainly applied to the three-component systems and rarely involved in the four-component separation systems.…”

Section: Simulated Moving Bed (Smb) Was Developed Originally By Unive...mentioning

confidence: 99%

Design and optimization of JO‐IEX process for highly efficient quaternary separation of 5′‐ribonucleotides

et al. 2022

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The developed JO‐IEX technology was applied to continuously separate four 5′‐ribonucleotides here. The unit contained seven columns with three separation steps, among which three columns were for the quaternary separation and the others for regeneration of resins. The operating conditions, that is, the critical flow rates in three separation steps were preliminarily designed according to the equilibrium theory and optimized by a three‐dimensional theoretical separation region approach. The feasibility of the JO‐IEX process and the separation performances were validated by four runs using the actual 5′‐ribonucleotides' enzymatic hydrolysate as feed solutions. The purities and yields of 5′‐ribonucleotides could reach above 97%. The productivity was enhanced to be 0.91 g/(kg h), and the desorbent consumption was reduced to be 1.01 L/g, compared to those of 0.70 g/(kg h) and 1.75 L/g in the fixed‐bed process. The technology proposed could be a potential technique in the continuous multicomponent ion‐exchange separation process.

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“…During the second step, the feed stream is closed and the unit works as a standard SMB where the less and more retained products are collected at the extract and raffinate ports. The use of two different adsorbents [134], solvent gradient [135] (see also the MCSGP process in Section 2.8), five-section SMB [76], with partial-feed [136], and partial-collecting strategies [77] have also been reported for multicomponent separations using a same unit.…”

Section: Multicomponent Separationsmentioning

confidence: 99%

Simulated Moving Bed Chromatography: From Concept to Proof‐of‐Concept

Gomes

Rodrigues

2011

Chem Eng & Technol

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This work presents a comprehensive insight about simulated moving bed (SMB) technology, from concept to unit operation and process demonstration. A particular relevance is given to SMB nonconventional modes of operation, modeling, and design of SMB-based separations as well as to the construction and operation of SMB units. A conventional separation of a racemic mixture of (S,R)-a-tetralol by means of the FlexSMB-LSRE® unit is addressed to better exemplify a state-ofthe-art SMB lab-scale process development and demonstration.

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Effect of a partial-feeding application on product purities and throughput of a five-zone simulated moving bed process for the separation of a ternary nucleoside mixture

Cited by 13 publications

References 20 publications

Enhanced separation of chlorogenic and gallic acids extracted from spent coffee grounds using a three‐zone simulated moving bed process with partial feed and partial collection strategies

Enhanced separation of chlorogenic and gallic acids extracted from spent coffee grounds using a three‐zone simulated moving bed process with partial feed and partial collection strategies

Design and optimization of JO‐IEX process for highly efficient quaternary separation of 5′‐ribonucleotides

Simulated Moving Bed Chromatography: From Concept to Proof‐of‐Concept

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