Simulated Moving Bed Chromatography: From Concept to Proof‐of‐Concept

Abstract

This work presents a comprehensive insight about simulated moving bed (SMB) technology, from concept to unit operation and process demonstration. A particular relevance is given to SMB nonconventional modes of operation, modeling, and design of SMB-based separations as well as to the construction and operation of SMB units. A conventional separation of a racemic mixture of (S,R)-a-tetralol by means of the FlexSMB-LSRE® unit is addressed to better exemplify a state-ofthe-art SMB lab-scale process development and demonstration.

Experiment and modeling for the separation of guaifenesin enantiomers using simulated moving bed and Varicol units

“…Furthermore, the productivity and solvent consumption can be improved further in this work by increasing the feed flow rate at the cost of losing S-GUA purity in extract stream, shown as No. 4 and No. 6 in Table 7.…”

“…Over the past decades, many modification technologies for the conventional SMB chromatography [3,4] have been proposed to expand the range of application and improve the separation performance, mainly, Varicol process, PowerFeed, ModiCon, Gradient SMB. Moreover, multi-component separation, for example, ternary separation, has also been accomplished by SMB process with three-zone or five-zone [5][6][7], the cascades of SMB process [8,9], and the JO process (pseudo-SMB) [10][11][12][13] et al…”

Chromatographic Separation of Verapamil Racemate Using a Varicol Continuous Multicolumn Process

“…tures (Ludemann-Hombourger et al, 2000;LudemannHombourger et al, 2002;Pais and Rodrigues, 2003;Gomes et al, 2010;Gomes and Rodrigues, 2012;Gong et al, 2014). Several theoretical and experimental results reported in the literature indicate that, due to the new degree of freedom, the Varicol process is a more favorable chromatographic technique than SMB, especially in terms of productivity and solvent consumption.…”

“…Varicol is a continuous preparative multicolumn chromatographic system that, in general, operates with a smaller number of columns than the conventional simulated moving bed (SMB) process (Ludemann-Hombourger et al, 2000;Ludemann-Hombourger et al, 2002;Gomes and Rodrigues, 2012;Schulte et al, 2005). The underlying principle of the Varicol process is the asynchronous shift of the inlet and outlet ports during an overall switching time.…”

Combination of space–time conservation element/solution element method and continuous prediction technique for accelerated simulation of simulated moving bed chromatography

“…Simulated moving bed (SMB) chromatography, as a continuous adsorption process, is an efficient technology for the separation of chemically similar components [1,2]. It takes advantages of continuous and countercurrent movement of the liquid and solid phase [3], in which the movement of solid phase is simulated by the switches of inlet and outlet lines at certain time intervals in the direction of the liquid phase flow.…”