Effect of a Deglycyrrhizinised Liquorice Compound on the Gastric Mucosal Barrier of the Dog

Abstract

The protective action against mucosal damage of a deglycyrrhizinised liquorice preparation was examined in Heidenhain pouches of four dogs. The net fluxes of hydrogen, sodium and lithium ion were measured before and after exposure of the mucosa to a 10-mM solution of taurocholate at pH 2. Hydrogen ion back diffusion from and sodium gain by the pouch were significantly increased by the bile acid. However, when pouches were first treated with a 1.2-percent aqueous solution of deglycyrrhizinised liquorice, the net increase in flux of H⁺ after exposure to bile was significantly less. Lithium did not act as a marker for H⁺ movement, for exposure to the 10-mM bile acid had no effect on mucosal permeability to Li⁺. These results suggest that deglycyrrhizinised liquorice protects gastric mucosa against the damaging effect of bile.

Side-Effects of Non-Steroidal Anti-Inflammatory Drugs on the Liver in Dogs and Hepatoprotective Effect of Plant Remedies

“…The cause of necrosis in these dogs seems to depend on herbal components but this thesis requires additional research. Furthermore, this result is not reflected by the results of blood examination and descriptions of the cited authors (16,25,34). Hepatic necrosis was not observed in the dogs that were treated with robenacoxib alone.…”

“…Similar to other NSAIDs, the administration of carprofen poseses a risk of idiosyncratic reaction in the liver. The hepatotoxic effects of carprofen in dogs have been reported by some authors (13,23,25). Nakagawa et al (26) described a fatal case of carprofen-induced hepatic toxicity in a young Siberian Husky, by blood tests that revealed an increase in ALAT (3489 U/L), ASPAT (2630 U/L), ALP (211 U/L), and TBA (51.2 µmol/L).…”

“…Long-term administration of liquorice preparations causes sodium chloride retention in the body and elevates the water content in tissues, which results in oedema and hypertension (1,19,25). As is clear from our clinical experience, liquorice products can be used in dogs for a short period of 1 to 4 weeks, without any impact on the ion profile, at 50 mg for dogs of 10 kg b.w.…”

“…Huo et al (16) and Yin et al (36) demonstrated the anti-oxidative action of liquorice extract and its hepatoprotective effect on the liver in rats and carps. It has also been shown that liquorice exhibits antiinflammatory properties due to the presence of glycyrrhizic acid and its metabolite glycyrrhetinic acid (1,19,25).…”

Effects of Sho-saiko-to (Xiao Chai Hu Tang), a Chinese Traditional Medicine, on the Gastric Function and Absorption of Tolbutamide in Rats

“…Kase et al 6) reported that Sho-saiko-to reduced the volume of gastric juice, acid output and pepsin output, causing the rise of intragastric pH in rats. Furthermore, the inhibitory eŠects of glycyrriza and ginger, crude components included in Sho-saiko-to, on gastric acid secretion and gastric emptying have been reported [7][8][9][10][11] . It is likely that such pharmacological eŠects of the herbal medicinals on the gastric functions give rise to a change in the pharmacokinetics of concomitantly administered drugs.…”