Effect of 200μG/day of vitamin k1 on the variability of anticoagulation control in patients on warfarin: A randomized controlled trial

Majeed, Habeeb; Rodger, Marc; Forgie, Melissa; Carrier, Marc; Taljaard, Monica; Scarvelis, Dimitrios; Gonsalves, Carol; Rodriguez, R; Wells, Philip S.

doi:10.1016/j.thromres.2013.07.019

Cited by 10 publications

(10 citation statements)

References 36 publications

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“…28 Three of the five RCTs received at least 3 points and were considered of high quality (►Table 2). 21,23,31 In three of the six studies the allocation concealment was adequate. 21,22,31 None of the observational studies was considered of high quality (►Table 3).…”

Section: Resultsmentioning

confidence: 98%

“…No abstracts were identified from the abstract books from the ISTH congress. Thus, 17 studies were potentially includible [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] : 2 of these 26,30 were published only as abstract and provided limited information on the study methods and results, and were finally excluded from our systematic review. Study identification and selection progression are summarized in ►Fig.…”

Section: Resultsmentioning

confidence: 99%

“…All the studies were written in English language. Five studies [21][22][23]27,31 were RCTs and the other 10 studies [16][17][18][19][20]24,25,28,29,32 were cohort or case-control studies. One was a secondary analysis of a previously published RCT.…”

Section: Resultsmentioning

confidence: 99%

“…One retrospective cohort study, 18 two prospective cohort studies, 16,20 and five RCTs [21][22][23]27,31 were included in this group (►Table 1). Note: Scale used to assess the methodological quality of observational studies; case-control and cohort studies may receive a maximum of 8 and 9 stars, respectively; studies receiving the maximum award were considered of high quality.…”

Section: Studies Investigating the Effect Of Daily Vitamin K Supplemementioning

confidence: 99%

“…Similarly, Majeed et al 31 randomized 54 patients on warfarin for at least 7 months with unstable anticoagulation (defined as at least 3 warfarin dose changes or at least 3 INRs outside of the target range in the previous 6 months) to a daily supplementation of 200 μg/day of Vitamin K or to a lactosebased placebo. Effectiveness of supplementation was primarily assessed by the percentage of TTR and secondarily by the SD of the patient's INR values, the proportion of out-of-range INRs, and the number of dose changes on warfarin.…”

Section: Studies Evaluating the Role Of Daily Vitamin K Supplementationmentioning

confidence: 99%

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Effect of Vitamin K Intake on the Stability of Treatment with Vitamin K Antagonists: A Systematic Review of the Literature

Dentali

Crowther

Galli³

et al. 2016

Semin Thromb Hemost

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Vitamin K antagonists (VKA) are highly effective for the primary and secondary prevention of arterial and venous thromboembolic events. However, patients treated with VKA have on average only 60% of their international normalized ratio (INR) values within the therapeutic range and INR instability is associated with an increased risk of thrombosis and bleeding events. Recent evidence suggests that poor dietary vitamin K intake may affect anticoagulation control, but the role of vitamin K in INR stability remains to be established. We performed a systematic review of the literature to assess the role of vitamin K dietary intake on the stability of VKA and the potential effect of daily vitamin K supplementation on VKA therapy. After a search in Medline and EMBASE databases, 15 studies for a total of 1,838 patients were included in our systematic review. Observational studies suggest an increased risk of unstable anticoagulation control in patients with lower daily vitamin K intake. On the other hand, the role of daily vitamin K supplementation or a diet with controlled vitamin K content in patients on VKA treatment remains to be established. Use of daily vitamin K supplementation may be associated with a clinically relevant increase in the time in therapeutic range in patients with unstable anticoagulation control. Conversely, this effect appears small and not clinically relevant when vitamin K was administered to an unselected population receiving VKA. Other large prospective studies are necessary to confirm our preliminary findings.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Studies Investigating the Effect Of Daily Vitamin K Supplemementioning

confidence: 99%

Section: Studies Evaluating the Role Of Daily Vitamin K Supplementationmentioning

confidence: 99%

See 3 more Smart Citations

Effect of Vitamin K Intake on the Stability of Treatment with Vitamin K Antagonists: A Systematic Review of the Literature

Dentali

Crowther

Galli³

et al. 2016

Semin Thromb Hemost

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Guidance for the practical management of warfarin therapy in the treatment of venous thromboembolism

Witt

Clark

Kaatz

et al. 2016

J Thromb Thrombolysis

115

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Venous thromboembolism (VTE) is a serious and often fatal medical condition with an increasing incidence. The treatment of VTE is undergoing tremendous changes with the introduction of the new direct oral anticoagulants and clinicians need to understand new treatment paradigms. This article, initiated by the Anticoagulation Forum, provides clinical guidance based on existing guidelines and consensus expert opinion where guidelines are lacking. Well-managed warfarin therapy remains an important anticoagulant option and it is hoped that anticoagulation providers will find the guidance contained in this article increases their ability to achieve optimal outcomes for their patients with VTE Pivotal practical questions pertaining to this topic were developed by consensus of the authors and were derived from evidence-based consensus statements whenever possible. The medical literature was reviewed and summarized using guidance statements that reflect the consensus opinion(s) of all authors and the endorsement of the Anticoagulation Forum’s Board of Directors. In an effort to provide practical and implementable information about VTE and its treatment, guidance statements pertaining to choosing good candidates for warfarin therapy, warfarin initiation, optimizing warfarin control, invasive procedure management, excessive anticoagulation, subtherapeutic anticoagulation, drug interactions, switching between anticoagulants, and care transitions are provided.

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Comparison of the effects of different treatment protocols on mortality in patients presenting with an INR≥10 due to warfarin-associated over-anticoagulation

İslam

Ademoğlu

UYGUN

et al. 2023

African Journal of Emergency Medicine

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Effect of 200μG/day of vitamin k1 on the variability of anticoagulation control in patients on warfarin: A randomized controlled trial

Cited by 10 publications

References 36 publications

Effect of Vitamin K Intake on the Stability of Treatment with Vitamin K Antagonists: A Systematic Review of the Literature

Effect of Vitamin K Intake on the Stability of Treatment with Vitamin K Antagonists: A Systematic Review of the Literature

Guidance for the practical management of warfarin therapy in the treatment of venous thromboembolism

Comparison of the effects of different treatment protocols on mortality in patients presenting with an INR≥10 due to warfarin-associated over-anticoagulation

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