Effect of 1,25(OH)2D3 on BALB/c mice infected with Leishmania mexicana

Ramos-Martı́nez, Espiridión; Villaseñor-Cardoso, M. I.; López-Vancell, M.R.; García-Vázquez, Francisco; Pérez‐Torres, Armando; Salaiza‐Suazo, Norma; Pérez-Tamayo, Ruy

doi:10.1016/j.exppara.2013.05.009

Cited by 21 publications

(20 citation statements)

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“…In veterinary medicine, low vitamin D levels in dogs have been recently linked with chronic enteropathy 28 , neoplasia 29 , and several infectious diseases 30, 31 . The establishment of associations between vitamin D levels and protozoan infections has yielded conflicting results in rodent models 20, 32–34 . However, recent studies have shed light on this issue by demonstrating a role for vitamin D in Babesia infections in dogs 30 , as well as in Plasmodium falciparum infection in children with vitamin D insufficiency associated with severe cerebral malaria in Uganda 21 .…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, there are several studies investigating the relationship between vitamin D and T cell immune response during the course of Leishmania infection. However, these studies focused on the cutaneous form in a rodent model and, in addition, they yielded discrepant results 32, 34, 48 . Our analysis did not show any association between Leishmania -specific IFN-γ or IL-10 production and vitamin D levels.…”

Section: Discussionmentioning

confidence: 99%

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Canine Leishmaniasis Progression is Associated with Vitamin D Deficiency

Rodríguez-Cortés

Martori

Martínez-Flórez

et al. 2017

Sci Rep

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The relationship between vitamin D deficiency and the risk of suffering from a plethora of health disorders, ranging from autoimmune processes to infectious diseases has been widely described. Nonetheless, the potential role of vitamin D in visceral leishmaniasis remains uncharacterized. In the Mediterranean basin, where the dog is leishmania’s main peri-domestic reservoir, control measures against the canine disease have shown beneficial effects on the incidence of human leishmaniasis. In this study, we measured the vitamin D levels in serum samples from a cohort of 68 healthy and disease dogs from a highly endemic area and we have also studied the relationship of these levels with parasitological and immunological parameters. The sick dogs presented significantly lower (P < 0.001) vitamin D levels (19.6 ng/mL) than their non-infected (31.8 ng/mL) and the asymptomatic counterparts (29.6 ng/mL). In addition, vitamin D deficiency correlated with several parameters linked to leishmaniasis progression. However, there was no correlation between vitamin D levels and the Leishmania-specific cellular immune response. Moreover, both the leishmanin skin test and the IFN-γ levels displayed negative correlations with serological, parasitological and clinical signs. Further studies to determine the functional role of vitamin D on the progression and control of canine leishmaniasis are needed.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Canine Leishmaniasis Progression is Associated with Vitamin D Deficiency

Rodríguez-Cortés

Martori

Martínez-Flórez

et al. 2017

Sci Rep

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“…The most active vitamin D metabolite is 1,25(OH) 2 D 3 , a steroid hormone whose synthesis involves the catalytic 1α‐hydroxylase that transforms 25(OH)D 3 to 1,25 (OH) 2 D 3 , a key factor in maintaining autoimmune tolerance, and participates in a variety of cell functions including differentiation, proliferation and apoptosis . The VD insufficiency is associated with the pathogenesis of many autoimmune diseases including SLE, and it has been shown that 1,25 (OH) 2 D 3 inhibited the maturation of dendritic cells (DCs) and the activation of Th1 cells in SLE patients .…”

Section: Introductionmentioning

confidence: 99%

Effects of 1,25(OH)₂D₃ and vitamin D receptor on peripheral CD4⁺/CD8⁺ double‐positive T lymphocytes in a mouse model of systemic lupus erythematosus

Ding

Xiang

2017

J Cellular Molecular Medi

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This study aims to explore effects of 1,25(OH)2D3 and vitamin D receptor (VDR) on peripheral CD4+/CD8+ double‐positive (DP) T lymphocytes in systemic lupus erythematosus (SLE). MRL‐LPr/LPr mice with SLE (n = 20) and normal MRL mice (n = 20) were assigned into the control group (normal mice, without feeding with 1,25(OH)2D3), the 1,25(OH)2D3 group (SLE mice, feeding with 1,25(OH)2D3), the VDR‐knock‐in + 1,25(OH)2D3 group (SLE mice, VDR‐knock‐in, feeding with 1,25(OH)2D3) and the VDR‐knockout group (normal mice, VDR‐knockout, without feeding with 1,25(OH)2D3) (n = 10 per group). Levels of T lymphocytes were measured by flow cytometry. The mRNA and proteins expressions of inflammatory factors were measured by qRT‐PCR and ELISA. Extracellular signal‐regulated kinase‐1/2 (ERK1/2) expression was measured by Western blotting. Compared with normal mice, SLE mice showed reduced levels of CD4+, CD4+/CD8+ ratio, and DP lymphocytes. The levels of SLE‐related indicators all increased significantly, followed with severe skin ulcers and urinary system infection. With the increase in time, skin ulcers and urinary system infection were significantly improved, levels of CD4+, CD4+/CD8+ ratio, and DP lymphocytes increased, and levels of SLE‐related indicators all decreased in the 1,25(OH)2D3 group. There were no significant changes in bioindicators in the control and the VDR‐knock‐in + 1,25(OH)2D3 groups. The symptoms of SLE gradually occurred in the VDR‐knockout group. This study demonstrates that VDR and 1,25(OH)2D3 could elevate CD4+/CD8+ DP T lymphocytes and reduce expressions of inflammatory factors, thus inhibiting the development and progression of SLE.

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“…As the most biologically active metabolite of vitamin D 3 , the steroid hormone 1,25(OH) 2 D 3 is associated with multiple cellular functions, inducing cell cycle arrest, inhibition of cell division, and DNA breakage, thus preventing cell proliferation (Ramos-Martínez et al, 2013;Liaudat et al, 2014). This molecule has been reported to be an effective immunomodulator that acts on MCs to inhibit their proliferation, decreases albuminuria and inflammatory cell infiltration, and accelerates repair of glomerular injury.…”

Section: Discussionmentioning

confidence: 99%

Effect of 1,25(OH<sub>2</sub>D<sub>3</sub> on the proliferation of human mesangial cells and their expression of Ki67

Zhao¹,

Zhang²,

Yang³

et al. 2017

Genet. Mol. Res.

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ABSTRACT. Previous studies have found that 1,25-dihydroxyvitamin D 3 [1,25(OH) 2 D 3 or VD 3 ] exerts many biological effects, including the inhibition of cell proliferation and induction of apoptosis, but its mechanism of action remains unclear. The goal of our investigation was to explore the effects of 1,25(OH) 2 D 3 on the proliferation of cultured human mesangial cells and their expression of Ki67 in vitro, and to establish its mechanism of action. Cultured human mesangial cells were randomly divided into the following four groups: normal control (N group; administered Dulbecco's modified Eagle's medium containing 5% fetal bovine serum), proliferation [ quantitative polymerase chain reaction were used to detect expression of Ki67 protein and mRNA, respectively. Compared to the N group, Ki67 levels were found to be higher in the EGF group but significantly lower in the VD 3 intervention group. Moreover, expression of Ki67 by cells in the EGF+VD 3 group was significantly lower than that of those in the EGF group. All of these differences were statistically significant (P < 0.05). In conclusion, 1,25(OH) 2 D 3 inhibited Ki67 expression and the proliferation of human mesangial cells; therefore, Ki67 may be regarded as a potent therapeutic target in mesangial proliferative glomerulonephritis.

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Effect of 1,25(OH)2D3 on BALB/c mice infected with Leishmania mexicana

Cited by 21 publications

References 58 publications

Canine Leishmaniasis Progression is Associated with Vitamin D Deficiency

Canine Leishmaniasis Progression is Associated with Vitamin D Deficiency

Effects of 1,25(OH)₂D₃ and vitamin D receptor on peripheral CD4⁺/CD8⁺ double‐positive T lymphocytes in a mouse model of systemic lupus erythematosus

Effect of 1,25(OH<sub>2</sub>D<sub>3</sub> on the proliferation of human mesangial cells and their expression of Ki67

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Effect of 1,25(OH)2D3 on BALB/c mice infected with Leishmania mexicana

Cited by 21 publications

References 58 publications

Canine Leishmaniasis Progression is Associated with Vitamin D Deficiency

Canine Leishmaniasis Progression is Associated with Vitamin D Deficiency

Effects of 1,25(OH)2D3 and vitamin D receptor on peripheral CD4+/CD8+ double‐positive T lymphocytes in a mouse model of systemic lupus erythematosus

Effect of 1,25(OH<sub>2</sub>D<sub>3</sub> on the proliferation of human mesangial cells and their expression of Ki67

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Effects of 1,25(OH)₂D₃ and vitamin D receptor on peripheral CD4⁺/CD8⁺ double‐positive T lymphocytes in a mouse model of systemic lupus erythematosus