2017
DOI: 10.1038/s41598-017-03662-4
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Canine Leishmaniasis Progression is Associated with Vitamin D Deficiency

Abstract: The relationship between vitamin D deficiency and the risk of suffering from a plethora of health disorders, ranging from autoimmune processes to infectious diseases has been widely described. Nonetheless, the potential role of vitamin D in visceral leishmaniasis remains uncharacterized. In the Mediterranean basin, where the dog is leishmania’s main peri-domestic reservoir, control measures against the canine disease have shown beneficial effects on the incidence of human leishmaniasis. In this study, we measu… Show more

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Cited by 37 publications
(43 citation statements)
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References 60 publications
(69 reference statements)
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“…Regarding leishmaniosis, it is known that some protective responses are associated with the activation of specific cell-mediated immunity and a Th1-pro-inflammatory immune response (Rodriguez-cortes et al, 2017). It seems that Th17 cells act synergistically with the Th1 population to control the growth of the pathogen.…”
Section: Concentrationsmentioning
confidence: 99%
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“…Regarding leishmaniosis, it is known that some protective responses are associated with the activation of specific cell-mediated immunity and a Th1-pro-inflammatory immune response (Rodriguez-cortes et al, 2017). It seems that Th17 cells act synergistically with the Th1 population to control the growth of the pathogen.…”
Section: Concentrationsmentioning
confidence: 99%
“…The relationship of vitamin D and diseases has also been investigated in dogs and cats, and some studies found association between low vitamin D status and some types of cancer (Selting, Sharp, Ringold, Thamm, & Backus, 2016;Wakshlag et al, 2011;Weidner et al, 2017), congestive heart failure (Kraus et al, 2014;Osuga et al, 2015), gastrointestinal diseases (Allenspach, Rizzo, Jergens, & Chang, 2017;Gow et al, 2011;Lalor et al, 2014;Titmarsh, Gow, Kilpatrick, Cartwright, et al, 2015;Titmarsh, Gow, Kilpatrick, Sinclair, et al, 2015), acute pancreatitis (Kim et al, 2017), acute polyradiculoneuritis (Laws, Kathrani, Harcourt-Brown, Granger, & Rose, 2018), chronic kidney disease (Cortadellas, Fernandez del Palacio, Talavera, & Bayón, 2010;Galler et al, 2012;Gerber, Hässig, & Reusch, 2003;Gerber, Hauser, & Reusch, 2004;Parker, Harjes, et al, 2017) and infectious diseases (Lalor et al, 2012;Rodriguez-Cortes et al, 2017;Rosa, Schoeman, Berry, Mellanby, & Dvir, 2013;. Although these studies do not prove a cause-effect relationship, they provide a basis for future studies to investigate possible positive effects of vitamin D supplementation on improving health status and reducing the risk of developing diseases.…”
Section: Introductionmentioning
confidence: 99%
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“…Dogs lacking this cytokine have more severe clinical symptoms, with higher parasitemia (Martínez-Orellana et al, 2017). Similarly, Th17 cells induce L. infantum control growth (Nascimento et al, 2015;Rodriguez-Cortes et al, 2017).…”
Section: General Aspects Of the Immunological Profile And Biomarkers mentioning
confidence: 99%
“…In contrast, the type 2 immune response, characterized IL-4, IL-5, IL-10, and TGF-β cytokines, is related to susceptibility in CVL (Sanches et al, 2014;Rodríguez-Cortés et al, 2016;Rodriguez-Cortes et al, 2017;Rossi et al, 2016;Solano-Gallego et al, 2016;Solcà et al, 2016;Tonin et al, 2016;De Martini et al, 2018). These susceptible dogs manifest a common pattern in the progression of clinical signs, with severity and variety of signs increasing with disease progression, in which most clinicopathological changes become evident after 12 months of infection (Foglia Manzillo et al, 2013).…”
Section: General Aspects Of the Immunological Profile And Biomarkers mentioning
confidence: 99%