EFEKTIVITAS SUPLEMENTASI TERIPANG EMAS (Stichopus hermanii) DALAM MENCEGAH TERJADINYA ORAL CANDIDIASIS PADA TIKUS WISTAR

Abstract

<p><strong><em>ABSTRACT</em></strong></p><p><em> </em></p><p><strong><em>Background:</em></strong><em> </em><em>Candida albicans is normal flora of oral cavity that can be pathogenic due to predisposition influence so that trigger Oral candidiasis. Stichopus hermanii suspected as an Oral candidiasis therapy because it contain antioxidant compound, antitumor and antifungi. <strong>Objective:</strong> Analyzing the effectiveness of Stichopus hermanii supplementation as a </em><em>protective effect</em><em> of oral </em><em>candidiasis in Rats exposure to smoke. <strong>Materials and Methods:</strong> This experiment is post test only group control design using 35 male rats divided into 5 groups(X). X1 (negative control), X2 (positive control), X3 (Stichopus hermanii powder 0,0225mg/kgBB), X4 (Stichopus hermanii powder 0,045mg/kgBB), X5 (Stichopus hermanii powder 0,09mg/kgBB). Candida albicans induced into the mouth by an oral swab using cotton bud 3 times a week for 8 weeks. Smoke exposure as a predisposition factor be given 3 bars per day for 8 weeks. The rats being killed and tongue biopsies measure the thickness of tongue epithelium. The obtained data analyzation using One Way ANOVA and LSD test. <strong>Result: </strong>There is a significant difference (p<0.05) between X1 and X2, X1 and X3, X1 and X4, X1 and X5, X2 and X3, X2 and X4, X2 and X5, X3 and X5</em>.<em> <strong>Conclusion:</strong> Adduction of Stichopus hermanii capable of reducing risk of Oral candidiasis. Supplementation of Stichopus hermanii powder 0,09mg/kgBB is the most effective reduce thickness of the tongue epithelium in the group that exposure to smoke and induced of Candida albicans.</em></p><p><strong><em>Keywords:</em></strong><em> Stichopus hermanii, Oral candidiasis, Tongue, Candida albicans, Thickness of Epithelium</em><em> </em></p><p><em><strong>Correspondence</strong>: Endah Wahjuningsih, Laboratorium Biologi Oral Fakultas Kedokteran Gigi Universitas Hang Tuah, Jl, Arif Rahman Hakim 150, Surabaya, Indonesia. Ph 031-5945864, fax: 031-5912191, e-mail address: endah1822@yahoo.com</em></p>

Pengaruh nystatin topikal dan terapi oksigen hiperbarik terhadap jumlah makrofag pada tikus kandidiasis oral kondisi imunosupresi: studi eksperimental laboratoris

“…18 Hewan coba di euthanasia dengan ketamin 10 mg/kg BB dan diazepam 5mg/kg BB, kemudian diambil lidahnya dan dibuat sediaan histopatologi dengan pengecatan Hematoxylin Eosin (HE). 21 Perhitungan jumlah makrofag dilakukan dengan menggunakan mikroskop cahaya pada perbesaran 1000 kali. 22 Analisis hasil penelitian dilakukan dengan uji Anova untuk mengetahui perbedaan jumlah makrofag pada kelompok penelitian, kemudian dilanjutkan dengan uji Post Hoc LSD untuk mengetahui perbedaan yang bermakna pada setiap kelompok penelitian.…”