Efek eugenol terhadap jumlah sel inflamasi pada pulpa gigi molar tikus Sprague Dawley

Enggardipta, Raras Ajeng; Haniastuti, Tetiana; Handajani, Juni

doi:10.22146/majkedgiind.8730

Cited by 11 publications

(9 citation statements)

References 12 publications

(17 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…An important role of macrophages in the process of tissue healing was the production of growth factors needed to initiate the proliferation of fibroblast cells that play a role in the healing process and tissue repair 13 . The presence of macrophages in the injured area reached peak concentrations around the third and fourth days and remained in the tissue until the healing process was completed 19 .…”

Section: Discussionmentioning

confidence: 99%

Effect of Purple Leaf Extract (Graptophyllum Pictum (L.) Griff) on the Number of Macrophage Cells in Pulp Perforation

2020

IJFMT

View full text Add to dashboard Cite

Background: Purple leaf (Graptophyllum pictum (L.) Griff) is one of Indonesia's traditional medicinal plants, which has anti-inflammatory properties which is expected to stop the inflammation of the pulp accompanied by perforation. Purpose: To determine the effect of giving purple leaves (Graptophyllum pictum (L.) Griff) to the number of macrophage cells in pulp perforation. Method: The study used 24 Wistar rats divided into four groups, namely control (K), and 3 treatment groups P1, P2, P3. Each group consisted of 6 rats prepared, then P1 was given 10% purple leaf extract, P2 was given 15% purple leaf extract, P3 was given 20% purple leaf extract. On the 3rd day, the Wistar rat was sacrificed and continued with the preparation of HPA. Calculation of the number of macrophages was obtained from the One-way ANOVA test. Results: There were significant differences between the control and treatment groups (K with P1, P2, P3), on the results of the One-way ANOVA difference-result test (p <0.05) Conclusion: Purple leaf extract (Graptophyllum pictum (L.) Griff) affected increasing the number of macrophage cells in pulp perforation after the 3rd day of treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of Purple Leaf Extract (Graptophyllum Pictum (L.) Griff) on the Number of Macrophage Cells in Pulp Perforation

2020

IJFMT

View full text Add to dashboard Cite

show abstract

“…Eventually, there will be pressure in prostaglandins, prostaxillin, endeperoxidase, and leukotriene number. 13,14 The vasodilatation of blood vessels and local blood stream will affect the inflammation cells migration. This condition will cause the disturbance in the inflammation chemotaxis to the tissue and detain the inflammation process, resulting in the decreasing of the macrophage cell number on the 7th day and optimizing the inflammatory process.…”

Section: Discussionmentioning

confidence: 99%

THE EFFECT OF KARAMUNTING (Rhodomyrtus Tomentosa) LEAF EXTRACT ON THE NUMBER OF MACROPHAGES IN PULP INFLAMMATION

Septiani¹,

Nahzi²,

Rasyid³

2021

Dentino

View full text Add to dashboard Cite

Background: Reversible pulpitis is an inflammation of dental pulp caused by the opening of the pulp due to cavities. One of the procedures in exposed pulp treatment is direct pulp capping using calcium hydroxide. However, this material has side effects, its high pH can cause necrosis, and due to that, a safer alternative material is needed. Karamunting leaf extract contains phenolic compounds, flavonoids, tannins, and saponins which have immunomodulatory properties that play an important role in healing exposed pulp. Objective: To determine the effect of karamunting leaf extract on the number of macrophages in pulp inflammation. Methods: This was a true experimental research with posttest-only group design, using simple random sampling that consist of 24 male Wistar rats which later be divided into 3 groups. The perforated rat dental pulp was then treated with karamunting leaf extract as a treatment group, calcium hydroxide as a positive control group, and not given any application (without drug) as a negative control group. The samples were analyzed histologically on the 3rd to 7th day after the application, inflammatory response occurred in all groups. Results: The two-way ANOVA results showed that there was a significant difference between the karamunting leaf extract group, the group that was not given drug, and the group given calcium hydroxide with a value p<0.05. Conclusion: Based on the research conducted, it is concluded that the administration of karamunting leaf extract can reduce the number of macrophages in pulp inflammation. Keywords: calcium hydroxid, exposed pulp, karamunting leaf, macrophages, pulp inflammation.

show abstract

“…22 NO can cause vasodilation so that inflammatory cells, including neutrophils as acute inflammatory cells, migrate towards injury. 23,24 EGCG extract, which was used in this study, is a polyphenol that acts as a radical scavenger. NO, which is a free radical, also binds to the -OH groups of EGCG.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of topical hydrogel Epigallocatechin-3-gallate against neutrophil cells in perforated dental pulp

et al. 2020

View full text Add to dashboard Cite

Background: One cause of pulpitis is mechanical trauma such as pulp perforation. The emergency treatment of pulpitis in a clinic uses eugenol. Eugenol in a high concentration causes cytotoxicity, which causes local necrosis and inhibits the recovery process, while in lower doses it can cause oral mucosal hypersensitivity. Due to these side effects, it is worth considering other biocompatible materials with minimal side effects, such as epigallocatechin-3-gallate (EGCG) which is found in green tea. As a polyphenol, EGCG has a radical scavenging ability, which has an effect on reducing the number of neutrophils. The application of EGCG is expected to reduce neutrophils on the second day after injury so the rehabilitation process is completed more quickly and ongoing inflammation and pulp necrosis is prevented. Purpose: To analyse the efficacy of topical hydrogel EGCG in reducing the number of neutrophils after 48 hours in the perforated dental pulp of Wistar rats. Method: 20 Wistar rats were divided equally into four groups, which were designated control (C) and treatment groups (T1, T2, T3). The upper first molar teeth of each rat were perforated and then T1, T2, and T3 were given 60 ppm, 90 ppm and 120 ppm hydrogel EGCG respectively. On the second day, the rats were sacrificed. HPA preparations were made to calculate the number of neutrophils in each group. Data was analysed using Kolmogorov–Smirnov, Levene’s, one-way ANOVA and Tukey HSD test (p<0.05). Results: There were significant differences between T2 and T3 compared with C and T1 (p<0.05), but no significant differences in the comparison of T1 with C and of T2 with T3 (p>0.05). Conclusion: 90 ppm hydrogel EGCG is effective in reducing the number of neutrophils in the perforated dental pulp of Wistar rats.

show abstract

Efek eugenol terhadap jumlah sel inflamasi pada pulpa gigi molar tikus Sprague Dawley

Cited by 11 publications

References 12 publications

Effect of Purple Leaf Extract (Graptophyllum Pictum (L.) Griff) on the Number of Macrophage Cells in Pulp Perforation

Effect of Purple Leaf Extract (Graptophyllum Pictum (L.) Griff) on the Number of Macrophage Cells in Pulp Perforation

THE EFFECT OF KARAMUNTING (Rhodomyrtus Tomentosa) LEAF EXTRACT ON THE NUMBER OF MACROPHAGES IN PULP INFLAMMATION

Efficacy of topical hydrogel Epigallocatechin-3-gallate against neutrophil cells in perforated dental pulp

Contact Info

Product

Resources

About