Efeito Protetor Do Resveratrol Na Doença De Alzheimer

Rosa, Moisés de Oliveira; Machado, Fernanda de Souza; Frusciante, Marina Rocha; Gutierrez, Lucila Ludmila Paula; Funchal, Cláudia

doi:10.25061/2527-2675/rebram/2017.v20i1.477

Cited by 5 publications

(3 citation statements)

References 35 publications

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“…O Alzheimer é conhecido como uma doença em idosos. Embora estejam disponíveis tratamentos específicos profiláticos e alguns experimentais como o Canabiol e/ou Resveratrol que podem modular o curso da doença e amenizar os sintomas (Rosa et al, 2017;Barbosa et al, 2020).…”

Section: Doença De Alzheimerunclassified

The use of Rosmarinus officinalis L. essential oil in Alzheimer's patients

Dias¹,

Filho

Porfiro³

2022

Braz. J. of Sci.

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text Rosmarinus officinalis is a species of the Lamiaceae family and is popularly known in Brazil as "field rosemary, golden rosemary, rosemary". The species is aromatic due to the presence of essential oil, a complex class of monoterpenes, sesquiterpenes and phenylpropanoids that are found in the aerial parts of the plant. Thus, the interest of studies on volatile compounds and their possible biological actions, mainly on pathological processes, are a subject of study. The use of essential oils in pharmacology and aromatherapy is remarkable. And R. officinalis essential oil is famous for its volatile compounds used in acetylcholinesterase inhibition models. The aim of the study was to review in the literature the use of R. officinalis oil and its use in Alzheimer's disease phytotherapy. A survey of studies (articles, dissertations and theses) on the use of rosemary essential oil on acetylcholinesterase inhibition was carried out. As a result, it was observed that the use of R. officinalis essential oil presents a significant amount of studies with excellent results of inhibiting this enzyme on Alzheimer's disease and on improving cognition and memory, mainly in models induced by scopolamine dementia. It is noted that still, little is known about the use of rosemary essential oil, this study being a review of the main biological uses, however, there is still much to research. Rosmarinus officinalis oil may be a new pharmacological prototype due to its volatile compounds with great aptitude in the treatment of pathologies such as Alzheimer's disease.

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Section: Doença De Alzheimerunclassified

The use of Rosmarinus officinalis L. essential oil in Alzheimer's patients

Dias¹,

Filho

Porfiro³

2022

Braz. J. of Sci.

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“…No que diz respeito ao tratamento, atualmente, dispõe-se apenas de medicamentos paliativos para a doença (Rosa et al, 2017), visando aliviar os sintomas, dado que não há cura definitiva para a doença de Alzheimer. A Food and Drug Administration (FDA), aprova cinco fármacos, apresentados na Tabela 1, para uso em pacientes acometidos pela doença, sendo eles a tacrina, a galantamina e a rivastigmina, utilizados em estágios leve a moderado, e o donepezilo, utilizado em estágios leve, moderado a severo (Patel, 2011).…”

Section: Introductionunclassified

Mirtilos e seus compostos fenólicos como fator neuroprotetor em condições neurodegenerativas da Doença de Alzheimer

Salviano,

Burigo,

Pincerati

et al. 2024

CLCS

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Doenças neurodegenerativas, como a doença de Alzheimer, são relacionadas à idade e caracterizadas pela morte neuronal e fatores entre neuroinflamação e excesso de radicais livres. Estudos com fontes vegetais que possuem propriedades antioxidantes e anti-inflamatórias, têm sido realizados, pois podem neutralizar radicais livres em excesso, mostrando-se promissoras como terapias alternativas, especialmente as espécies de mirtilo, devido seu elevado teor de compostos fenólicos. O objetivo desse artigo foi compilar e discutir informações, em bases de dados de artigos científicos como Pubmed, ScienceDirect, Scielo e Google Scholar, sem limite de ano de publicação, nas línguas inglesa e portuguesa, que englobam compostos fenólicos presentes nos frutos de mirtilo, com propriedades que conferem neuroproteção em condições neurodegenerativas da doença de Alzheimer (DA). Além de proteção contra o envelhecimento, estresse oxidativo e reversão de déficits cognitivos, decorrente da utilização de compostos isolados e extratos brutos dos frutos e das folhas no tratamento e prevenção de doenças neurodegenerativas como a DA, alguns dos estudos compilados neste artigo, apresentam o uso de Rosmarinus spp., Vaccinium spp. e compostos encontrados em morangos, em espinafre e em vitamina E, com resultados promissores em modelos diferentes de neurodegeneração. Compostos como antocianinas, eugenol, taraxerol, resveratrol, quercetina, entre outros, também exibiram resultados relevantes para esta área de pesquisa, pois sugeriram proteção contra a DA. Portanto, é de importância significativa novos estudos com estes compostos como tratamento e prevenção da DA para trazer esperança de melhora em aspectos relacionados à qualidade de vida do paciente e em prejuízos cognitivos associados à doença.

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“…Some researchers have demonstrated that wine is beneficial for health with protective effects on different target organs (Rosa et al, 2017;Anastácio 2012;Penna & Hecktheuer 2004). Red wine, if consumed in moderation, has the most benefits.…”

Section: Introductionmentioning

confidence: 99%

Merlot wine and the metabolic and cardiovascular changes in LDLR -/- mice

Anjos,

Silva,

Marinho

et al. 2023

CeN

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Dyslipidemia is a risk factor for the insulin resistance and cardiovascular diseases, such as left ventricular hypertrophy and remodeling of the arterial. Resveratrol, present in grapes, is a possible mediator of cardiovascular protection. The study aimed to evaluate the effect of red wine from the Merlot grape (Vitis vinifera L.) on dyslipidemia and its involvement in male mice, knockout for the LDL receptor gene (LDLR-/-). The mice were divided into 4 experimental groups: Group S received standard rodent food; Group SV received standard feed for rodents and wine; Group HL received high fat diet; Group HLV received hyperlipidic food and wine orally for 60 days. All animals received water and food ad libitum during this period. After this period, they remained fasting and were then anesthetized. Blood was collected for serum analysis of triglycerides, total cholesterol, and its fractions (HDL and VLDL), C-reactive protein, glucose, and insulin to compare the data. Morphometric and histological analyzes of the left ventricle and abdominal aorta were also performed. It was found that Merlot red wine has antidyslipidemic effects on genetic dyslipidemia, associated with food, partially preventing insulin resistance, hyperinsulinemia and increased CRP; as well as cardiovascular effect, partially preventing LVH and arterial remodeling.

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Efeito Protetor Do Resveratrol Na Doença De Alzheimer

Cited by 5 publications

References 35 publications

The use of Rosmarinus officinalis L. essential oil in Alzheimer's patients

The use of Rosmarinus officinalis L. essential oil in Alzheimer's patients

Mirtilos e seus compostos fenólicos como fator neuroprotetor em condições neurodegenerativas da Doença de Alzheimer

Merlot wine and the metabolic and cardiovascular changes in LDLR -/- mice

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