Efeito do exercício físico e estatinas na função muscular em animais com dislipidemia

Accioly, Marilita Falângola; Filho, José Carlos Silva Camargo; Padulla, Susimary Aparecida Trevizan; Lima, Ana Lúcia Z; Bonfim, Mariana Rotta; Carmo, Edna Maria do; Pinhel, Marcela Augusta de Souza; Lima, Mariana Accioly; Azoubel, Reinaldo; Brandão, Antônio Carlos; Souza, Dorotéia Rossi Silva

doi:10.1590/s1517-86922012000300013

Cited by 4 publications

(5 citation statements)

References 23 publications

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“…Considering the body’s adaptation to training, it can be assumed that muscle responses to chronic exercises are different from those observed in acute exercises. An experimental study with an animal model, which evaluated the effects of 60 minutes of moderate aerobic physical activity (9.75 m/min) on a treadmill, performed five times a week for two months, concomitant with simvastatin (20 mg/kg) and fluvastatin (20 mg/kg) treatment in rats showed that the drug use caused mild to severe muscle changes in the soleus muscle, which were more frequent when the drug was associated with exercise 43 .…”

Section: Resultsmentioning

confidence: 99%

Treatment of Dyslipidemia with Statins and Physical Exercises: Recent Findings of Skeletal Muscle Responses

Bonfim¹,

Oliveira²,

Amaral³

et al. 2015

Arquivos Brasileiros De Cardiologia

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Statin treatment in association with physical exercise practice can substantially reduce cardiovascular mortality risk of dyslipidemic individuals, but this practice is associated with myopathic event exacerbation. This study aimed to present the most recent results of specific literature about the effects of statins and its association with physical exercise on skeletal musculature. Thus, a literature review was performed using PubMed and SciELO databases, through the combination of the keywords “statin” AND “exercise” AND “muscle”, restricting the selection to original studies published between January 1990 and November 2013. Sixteen studies evaluating the effects of statins in association with acute or chronic exercises on skeletal muscle were analyzed. Study results indicate that athletes using statins can experience deleterious effects on skeletal muscle, as the exacerbation of skeletal muscle injuries are more frequent with intense training or acute eccentric and strenuous exercises. Moderate physical training, in turn, when associated to statins does not increase creatine kinase levels or pain reports, but improves muscle and metabolic functions as a consequence of training. Therefore, it is suggested that dyslipidemic patients undergoing statin treatment should be exposed to moderate aerobic training in combination to resistance exercises three times a week, and the provision of physical training prior to drug administration is desirable, whenever possible.

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Section: Resultsmentioning

confidence: 99%

Treatment of Dyslipidemia with Statins and Physical Exercises: Recent Findings of Skeletal Muscle Responses

Bonfim¹,

Oliveira²,

Amaral³

et al. 2015

Arquivos Brasileiros De Cardiologia

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“…The animals were fed a hypercholesterolemic diet to cause hypercholesterolemia and better mimic the effects of treatment. 5 The animals gained increasing weight throughout the hypercholesterolemic feeding. This increased weight gain can be explained by the natural growth of the animals combined with a diet rich in lipids.…”

Section: Discussionmentioning

confidence: 98%

“… 19 Rats in which simvastatin is used present morphological and structural changes that may be aggravated when the use of this drug is associated with exercise. 5 , 20 Bonfim et al 21 reported that the association of simvastatin with treadmill exercise led to an increase in the muscle injury in rats. In the present study, no statistically significant differences were observed in the mechanical properties of animals, regardless of the use of simvastatin.…”

Section: Discussionmentioning

confidence: 99%

“…The animals received a hypercholesterolemic diet based on the AIN-93 from the American Institute of Nutrition, composed of 18% lipids per kg (1.25% of cholesterol) for 90 days, for hypercholesterolemia induction. 5 After 90 days, blood samples were drawn through cardiac puncture and laboratory tests were performed to confirm the elevation of the animals’ cholesterol level.…”

Section: Methodsmentioning

confidence: 99%

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Effects of simvastatin associated with exercise on the mechanical resistance of muscle and bone in rats

Yamanaka

Ribeiro

Yanagihara

et al. 2018

Revista Brasileira de Ortopedia (English Edition)

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ObjectiveThe aim of the present study was to evaluate the influence of simvastatin on mechanical properties of muscle and bone in hypercholesterolemic rats submitted to physical exercise.MethodsTen male Wistar rats were submitted to a high-fat diet rich in cholesterol for 90 days. The animals were then divided into two groups: animals treated with physical exercise (EG) and animals treated with physical exercise and simvastatin (ESG). Protocols for physical exercise in water and simvastatin administration were performed for eight weeks. After this period, the animals were euthanized; the left tibia and right gastrocnemius muscle were dissected for mechanical analysis, and the right tibia for densitometry. The data were analyzed using Student's t-test, considering a level of significance of 5%.ResultsThe comparison of maximum load and stiffness revealed no significant differences between the groups for both the tibia (p = 0.851 and p = 0.259) and the gastrocnemius (p = 0.911 and p = 0.083). The tibia BMD also showed no significant difference between the groups (p = 0.803).ConclusionSimvastatin had no negative effects on mechanical properties in tibia and gastrocnemius of hypercholesterolemic rats submitted to physical exercise.

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“…The material was sectioned using semi-serial cuts of 8mm, obtaining three 50 mm-cuts each by means of a microtome cryostat Microm HM 505 E, -20ºC. Histological analysis was performed by staining the material with hematoxylin and eosin (HE) (Accioly et al, 2012).…”

Section: Methodsmentioning

confidence: 99%

Effect of Statins and Aerobic Physical Exercise on Liver Function in Dyslipidemic Rats: Morphometric Study

Accioly

Souza²,

Padulla

et al. 2013

Int. J. Morphol.

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SUMMARY:The present study was carried out to evaluate the effect of statins associated with physical exercise (PE) in liver cells in dyslipidemic rats through cariometry. The animals were divided into six groups: animals subjected to a hypercholesterolemic diet (HD), simvastatin, with (G1) and without (G2) physical exercise (PE); HD submitted (G3) or not (G4) to PE, and commercial food diet (F) with (G5) and without (G6) PE. Histological analysis of the liver was performed by staining the slides with hematoxylin and eosin. The cariometric study included measuring the major and minor diameters of the hepatocytes nuclei. The Shapiro-Wilk test was also performed. To determine the differences among the groups, the Kruskal-Wallis Test with Dunn's post-test were conducted. The significance level was set at 5%. No difference was found in the hepatocytes nuclei between G5 and G6. When these groups were related with G3 and G4, reduced nuclei were observed. There was no difference between G1 and G6. The comparison between G6 and G2 showed that the nuclei in G2 were smaller. No difference was detected between G5 and G1. Changes were observed in the nuclei shape in G2 in comparison to G1. Considering G2 and G3, a decrease in the size of nuclei was observed in G3. On the other hand, G2 showed changes in shape in the comparative analysis with G4. The size and shape of G1 nuclei were larger than G3 as well as changes in shape were observed when compared to G4. G4 showed smaller nuclei than G3. Therefore, F, associated or not with the practice of PE, does not alter the size and shape of the hepatocytes nuclei; HD combined with sedentarism influences changes in the morphometric parameters of hepatocytes; and the association of simvastatin and PE seems to protect the hepatocytes nuclei with regard to HD.

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Efeito do exercício físico e estatinas na função muscular em animais com dislipidemia

Cited by 4 publications

References 23 publications

Treatment of Dyslipidemia with Statins and Physical Exercises: Recent Findings of Skeletal Muscle Responses

Treatment of Dyslipidemia with Statins and Physical Exercises: Recent Findings of Skeletal Muscle Responses

Effects of simvastatin associated with exercise on the mechanical resistance of muscle and bone in rats

Effect of Statins and Aerobic Physical Exercise on Liver Function in Dyslipidemic Rats: Morphometric Study

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