EFEITO CITOTÓXICO E GENOTÓXICO DE Crescentia cujete L. (BIGNOCIACEAE) ATRAVÉS DO BIOTESTE Allium cepa

Macedo, Weslaine de Almeida; Mello, Vanessa; Santos, Bruna Natália Veloso dos; Fernandes, Lindisai; Karsburg, Isane Vera

doi:10.18677/agrarian_academy_2018b7

Cited by 3 publications

(3 citation statements)

References 7 publications

(7 reference statements)

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“…In previous studies, some bioactive compounds of Crescentia cujete have already been isolated and identified through spectrometric techniques, such as preliminary phytochemical and chromatographic screenings. It is reported by Macedo et al (2018) that several compounds are present in the leaf extract, the main ones being naphthoquinones, glycosides, plumeride, aucubin, irioids and asperuloside.…”

Section: Resultsmentioning

confidence: 99%

Analysis of the cytotoxic effects of the fruit extract of Crescentia cujete L.

Januário¹,

Diniz²,

Barros³

et al. 2022

RSD

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Introduction: Over time, treatments with plant species have become more effective for the vast majority of the population, even with a vague collection of scientific research that proves their safety and effectiveness. Among these different species is the arboreal Crescentia cujete L., which is widely distributed in Northeastern Brazil. It is applied with various therapeutic purposes, from antihypertensive, analgesic, antispasmodic and some gynecological disorders. Objective: To analyze the possible cytotoxicity of the hydroalcoholic extract of the fruit. Methodology: The extract was obtained through dynamic maceration in a hydroalcoholic solution. A cytotoxicity analysis was carried out based on the methodologies of osmotic fragility and lethality against Artemia salina L. 45.32%. Conclusion: Therefore, further research aimed at safety and possible applicability of the extract in question is encouraged.

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Section: Resultsmentioning

confidence: 99%

Analysis of the cytotoxic effects of the fruit extract of Crescentia cujete L.

Januário¹,

Diniz²,

Barros³

et al. 2022

RSD

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“…Then the Kif2a protein tries to repair the damage, if it is not possible to reverse the situation then the anomalies arise, and the cell blocks the division process mainly in the anaphase, causing irregularities such as lagging and chromosomal breaks (Macedo et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Cytotoxicity, genotoxicity and antiprofilerative effect of Costus Scaber Ruiz & Pav (Costaceae): a contribution to folk medicine, oncology and genetic improvement/ Citotoxicidade, genotoxicidade e efeito antiprofilerativo de Costus scaber Ruiz & Pav (Costaceae): uma contribuição para medicina popular, oncologia e melhoramento genético

Macedo¹,

Leite²,

Karsburg³

2021

BJDV

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Costus scaber is an herbaceous species that has hard and cylindrical stems and can reach up to 80 cm in height. It has an inflorescence at the end of the stalk from 6 to 10 cm long, which is surrounded by scaly bracts. Due to this species interesting medicinal potential, the objective of this study was to analyze its cytotoxic and genotoxic effect. The cytogenotoxic and antiprofilerative effect was evaluated using the bioindicator Allium cepa via the direct and indirect method. Fresh Leaves of C. scaber were used for the infusion. Three different concentrations of infusions were elaborated, which were 2, 3 and 4 g/L -1 for each of the different methods, and were analyzed at 24, 48 and 72 hours. Five slides were made per treatment, with 300 cells per slide. Statistical analyses were performed in the R program. The cytotoxic, genotoxic and antiprofilerative effects were found in certain concentrations and at certain exposure periods, and it was also noted that, in general, as the concentration and exposure period increased, the mitotic index decreased and the antiprofilerative effect increased. Several chromosomal abnormalities were found in the infusions analyzed. Therefore, according to the results found, it can be concluded that C. scaber has great potential for genetic improvement of plants in the field of drug production mainly in the field of oncology.

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“…No entanto, a fase orgânica da C. Cujete L., inibiu 100% a germinação das sementes das duas espécies receptoras, obtendo o efeito citotóxico na concentração de 0,5%, considerada relativamente baixa (PEREIRA MS, et al, 2015). Macedo WA, et al (2018) concluíram em estudo que a espécie pode ser tóxica ao organismo humano e animal, em seus ensaios pode observar que houve presença de anomalias e baixo índice mitótico ocasionando baixa divisão celular em concentrações mais elevadas.…”

Section: Atividades Biológicas Embasadas Cientificamenteunclassified

Aspectos fitoquímicos e potencialidades biológicas da Crescentia: uma revisão narrativa

Lima¹,

Santos²,

Ramos³

et al. 2020

Acervo Saúde

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Objetivo: Revisar e compilar informações descritas na literatura sobre a composição química e atividades biológicas do gênero Crescentia. Revisão bibiografica: A Crescentia cujete L. mostrou ser tão eficaz quanto Crescentia alata kunt em relação aos efeitos terapêuticos. As espécies possuem diversos compostos bioativos isolados e identificados através de técnicas espectrométricas, compostos estes, ligados às atividades biológicas apresentadas nas espécies do gênero, até mesmo as atividades que necessitam de relativa toxicidade, como atividades antimicrobiana e anticancerígena, destacando-se como uma futura candidata a fornecer seus componentes para a indústria farmacêutica. Muitas espécies são utilizadas, no uso popular, de forma inadequada, tendo em vista que grande parte dos usuários não possuem conhecimentos científicos acerca das suas atividades biológicas, resultando por vezes, em efeitos adversos. Considerações finais: Apesar do uso do gênero para fins terapêuticos se mostrar bastante difundido, em algumas situações essa prática pode não ser recomendada, devido a toxicidade que permeia as substâncias presentes, fazendo-se necessários estudos de toxicidade de modo a estimar a segurança bem como os verdadeiros potenciais terapêuticos.

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EFEITO CITOTÓXICO E GENOTÓXICO DE Crescentia cujete L. (BIGNOCIACEAE) ATRAVÉS DO BIOTESTE Allium cepa

Cited by 3 publications

References 7 publications

Analysis of the cytotoxic effects of the fruit extract of Crescentia cujete L.

Analysis of the cytotoxic effects of the fruit extract of Crescentia cujete L.

Aspectos fitoquímicos e potencialidades biológicas da Crescentia: uma revisão narrativa

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