Editorial of Special Issue “Nanostructured Light-Emitters”

Nguyen, Hieu Pham Trung

doi:10.3390/mi11060601

Cited by 3 publications

(3 citation statements)

References 14 publications

(15 reference statements)

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“…Currently, disinfection by UV LEDs is limited by the relatively low radiant flux compared to mercury LP lamps. However, significant progress has been made in the development of photonic devices and the use of nanostructured materials for LEDs due to their unique geometry [ 43 , 44 ]. Nanostructures in small dimensions can be integrated into a variety of technological platforms, offering novel physical and chemical properties for high-performance light-emitting devices.…”

Section: Discussionmentioning

confidence: 99%

UV light-emitting diode (UV-LED) at 265 nm as a potential light source for disinfecting human platelet concentrates

et al. 2021

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The risk of sepsis through bacterial transmission is one of the most serious problems in platelet transfusion. In processing platelet concentrates (PCs), several methods have been put into practice to minimize the risk of bacterial transmission, such as stringent monitoring by cultivation assays and inactivation treatment by photoirradiation with or without chemical agents. As another potential option, we applied a light-emitting diode (LED) with a peak emission wavelength of 265 nm, which has been shown to be effective for water, to disinfect PCs. In a bench-scale UV-LED exposure setup, a 10-min irradiation, corresponding to an average fluence of 9.2 mJ/cm2, resulted in >2.0 log, 1.0 log, and 0.6 log inactivation (mean, n = 6) of Escherichia coli, Staphylococcus aureus, and Bacillus cereus, respectively, in non-diluted plasma PCs. After a 30-min exposure, platelet counts decreased slightly (18 ± 7%: mean ± SD, n = 7); however, platelet surface expressions of CD42b, CD61, CD62P, and PAC-1 binding did not change significantly (P>0.005), and agonist-induced aggregation and adhesion/aggregation under flow conditions were well maintained. Our findings indicated that the 265 nm UV-LED has high potential as a novel disinfection method to ensure the microbial safety of platelet transfusion.

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Section: Discussionmentioning

confidence: 99%

UV light-emitting diode (UV-LED) at 265 nm as a potential light source for disinfecting human platelet concentrates

et al. 2021

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“… 35,37,38 However, a major challenge for all available biosensors is early confirmation of SARS-CoV-2 with a low level of viral RNA at the onset of the infection to avoid further spread. 39,40 Among all the portable platform solutions to this task, optical biosensors ( Fig. 2 ) present a strong conceivable potential to grow expeditiously in healthcare and biomedical fields as they provide a condensed, accurate analytical tool to promote mass-scale screening of a broad range of samples through different parameters.…”

Section: Introductionmentioning

confidence: 99%

“… 44 As a result, they are very promising to become the future COVID-19 diagnostic tools as they provide sensitive and durable point-of-care testing (POCT) devices, which is imperative for controlling epidemics like SARS-CoV-2. 39,42,45–48 …”

Section: Introductionmentioning

confidence: 99%

Fast, accurate, point-of-care COVID-19 pandemic diagnosis enabled through advanced lab-on-chip optical biosensors: Opportunities and challenges

Asghari

Wang

Yoo

et al. 2021

Applied Physics Reviews

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The sudden rise of the worldwide severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in early 2020 has called into drastic action measures to perform instant detection and reduce the rate of spread. Common clinical and nonclinical diagnostic testing methods have been partially effective in satisfying the increasing demand for fast detection point-of-care (POC) methods to slow down further spread. However, accurate point-of-risk diagnosis of this emerging viral infection is paramount as the need for simultaneous standard operating procedures and symptom management of SARS-CoV-2 will be the norm for years to come. A sensitive, cost-effective biosensor with mass production capability is crucial until a universal vaccination becomes available. Optical biosensors can provide a noninvasive, extremely sensitive rapid detection platform with sensitivity down to ∼67 fg/ml (1 fM) concentration in a few minutes. These biosensors can be manufactured on a mass scale (millions) to detect the COVID-19 viral load in nasal, saliva, urine, and serological samples, even if the infected person is asymptotic. Methods investigated here are the most advanced available platforms for biosensing optical devices that have resulted from the integration of state-of-the-art designs and materials. These approaches include, but are not limited to, integrated optical devices, plasmonic resonance, and emerging nanomaterial biosensors. The lab-on-chip platforms examined here are suitable not only for SARS-CoV-2 spike protein detection but also for other contagious virions such as influenza and Middle East respiratory syndrome (MERS).

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Modern Lab-on-Chip Biosensors Application on Infectious COVID-19 Detection

Barua

Sarkar

Datta

2023

Advances in MEMS and Microfluidic Systems

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The unexpected increase of the global SARS-CoV-2 or COVID-19 pandemic in early 2020 has required exceptional methods to accomplish instant detection and decrease the spread rate. This chapter highlights the advance of lab-on-chip biosensing devices for the identification of COVID-19 infection. In this chapter, the authors study the roles of using lab-on-chip equipment in response to the present global COVID-19 pandemic, comprising their potential for rapid sample-to-answer processing times and facility of incorporation into a variety of healthcare backgrounds.

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Editorial of Special Issue “Nanostructured Light-Emitters”

Cited by 3 publications

References 14 publications

UV light-emitting diode (UV-LED) at 265 nm as a potential light source for disinfecting human platelet concentrates

UV light-emitting diode (UV-LED) at 265 nm as a potential light source for disinfecting human platelet concentrates

Fast, accurate, point-of-care COVID-19 pandemic diagnosis enabled through advanced lab-on-chip optical biosensors: Opportunities and challenges

Modern Lab-on-Chip Biosensors Application on Infectious COVID-19 Detection

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