The sudden rise of the worldwide severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in early 2020 has called into drastic action measures to perform instant detection and reduce the rate of spread. Common clinical and nonclinical diagnostic testing methods have been partially effective in satisfying the increasing demand for fast detection point-of-care (POC) methods to slow down further spread. However, accurate point-of-risk diagnosis of this emerging viral infection is paramount as the need for simultaneous standard operating procedures and symptom management of SARS-CoV-2 will be the norm for years to come. A sensitive, cost-effective biosensor with mass production capability is crucial until a universal vaccination becomes available. Optical biosensors can provide a noninvasive, extremely sensitive rapid detection platform with sensitivity down to ∼67 fg/ml (1 fM) concentration in a few minutes. These biosensors can be manufactured on a mass scale (millions) to detect the COVID-19 viral load in nasal, saliva, urine, and serological samples, even if the infected person is asymptotic. Methods investigated here are the most advanced available platforms for biosensing optical devices that have resulted from the integration of state-of-the-art designs and materials. These approaches include, but are not limited to, integrated optical devices, plasmonic resonance, and emerging nanomaterial biosensors. The lab-on-chip platforms examined here are suitable not only for SARS-CoV-2 spike protein detection but also for other contagious virions such as influenza and Middle East respiratory syndrome (MERS).

This paper reports the first high speed roll-to-roll printable transistor using a carbon nanotube (CNT) semiconducting layer. The transistor is made possible through the development of a pulsed light curable CNT ink compatible with typical drop on demand inkjet cartridges. This CNT ink uses a xylene based solvent with methanol, glycerin, and Triton X-100 modifiers to create an evaporable solution with appropriate absorption spectra for a mercury or xenon flash lamp with strong energy transmission in the UVB to mid visible light range, allowing the solution to absorb the energy from the flash lamp and evaporate. Transistor dimensions were defined by the capabilities of a typical roll-to-roll drop on demand cartridge. The final device demonstrated an on/off ratio of 104, representing performance similar to gravure printed devices. This represents the first CNT ink which can be used in high speed production methods without long thermal curing steps in the workflow.

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