Editorial: Heart Failure in Type 2 Diabetes – The “Forgotten” Complication

Guja, Cristian; Miulescu, Rucsandra Dănciulescu

doi:10.2478/rjdnmd-2018-0014

Cited by 5 publications

(4 citation statements)

References 43 publications

(32 reference statements)

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“…The known mechanisms and pathways involved in early cardiomyocytic damage and subsequent aggravation are metabolic disturbances (decreased glucose oxidation, increased free fatty acids), impaired cellular function (inadequate calcium handling, augmented oxidative stress, mitochondrial dysfunction), structural alterations (advanced glycation end-product, cardiomyocyte hypertrophy), in addition to the activation of the renin-angiotensin-aldosterone system (fibrosis and cardiomyocyte stiffness) and cardiac autonomic neuropathy. These are triggered by hyperglycemic and lipotoxic anomalies related to insulin resistance, the prominent feature in type 2 diabetes [21,22,23,24,25,26,27,28,29,30]. Figure 2 summarizes the cellular, structural, and functional anomalies, the main imaging features, and the serological biomarkers involved in the earlier stages of diabetic cardiomyopathy [23,25,31,32,33,34,35,36,37].…”

Section: Left Ventricular Diastolic Dysfunctionmentioning

confidence: 99%

Left Ventricular Diastolic Dysfunction in Type 2 Diabetes—Progress and Perspectives

et al. 2019

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In-depth understanding of early cardiovascular manifestations in diabetes is high on international research and prevention agendas given that cardiovascular events are the leading cause of death for diabetic patients. Our aim was to review recent developments in the echocardiographic assessment of left ventricular diastolic dysfunction (LVDD) as a telltale pre-clinical disturbance preceding diabetic cardiomyopathy. We analyzed papers in which patients had been comprehensively assessed echocardiographically according to the latest LVDD guidelines (2016), and those affording comparisons with previous, widely used recommendations (2009). We found that the updated algorithm for LVDD is more effective in predicting adverse cardiovascular events in patients with established LVDD, and less specific in grading other patients (labelled “indeterminate”). This may prove instrumental for recruiting “indeterminate” LVDD cases among patients with type 2 diabetes mellitus (T2DM) in future screening programs. As an interesting consideration, the elevated values of the index E/e’ can point to early diastolic impairment, foretelling diabetic cardiomyopathy. Identifying subclinical signs early makes clinical sense, but the complex nature of T2DM calls for further research. Specifically, longitudinal studies on rigorously selected cohorts of diabetic patients are needed to better understand and predict the subtle, slow onset of cardiac manifestations with T2DM as a complicating backdrop.

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Section: Left Ventricular Diastolic Dysfunctionmentioning

confidence: 99%

Left Ventricular Diastolic Dysfunction in Type 2 Diabetes—Progress and Perspectives

et al. 2019

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“…Diabetes mellitus (DM) is a multifactorial metabolic disorder, characterized by hyperglycemia caused by insulin deficiency or insulin resistance [1]. DM is a significant public health issue, being one of the major contributors to morbidity and mortality in the modern societies [2]. The number of DM patients in the developed countries of the world is 2-6% of the total population.…”

Section: Background and Aimsmentioning

confidence: 99%

The Indices of Nitric Oxide System in Rats with Carrageenan-Induced Enterocolitis Combined with Diabetes Mellitus

Krynytska

Marushchak

2018

Romanian Journal of Diabetes Nutrition and Metabolic Diseases

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Background and aims: Diabetes mellitus (DM) represents a considerable public health issue, being one of the major causes of morbidity and mortality in the modern societies. Chronic hyperglycemia is accompanied by significant physiological, biochemical, and histological changes, e.g. development of oxidative stress that affects the motor activity of the intestine. This study aimed to evaluate the indices of nitric oxide (NO) system in blood serum and colon tissue supernatant of rats with carrageenan-induced enterocolitis combined with streptozotocin-induced diabetes. Material and methods: The total NOS activity was determined by monitoring the rate of conversion of L-arginine into citrulline. The total quantity of NO metabolites was assessed by evaluating their amount, which included nitrite ions that were initially present in the sample (NO2−) and nitrate ions reducted to nitrites (NO3−). Results: We found a significant increase in total NOS activity in colon tissue of all experimental groups vs. control animals (54.8, 30.6 and 79.2 % respectively). The total content of NO metabolites in colon tissue of all experimental groups also significantly increased (2.8, 1.9 and 3.4 times respectively) compared to the control animals. Conclusions: We observed activation of nitroxydergic process in blood serum and colon tissue of rats with carrageenan-induced enterocolitis. Nitroxydergic processes markedly intensified in rats with carrageenan-induced enterocolitis combined with diabetes mellitus.

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“…На сегодняшний день эпидемиологические данные указывают на преобладание среди пациентов с СД 2 типа сердечной недостаточности с сохраненной фракцией выброса (ХСН-сФВ) [9,10], а стратификация риска в данной группе остается актуальной и малоизученной проблемой [11,12,13]. Сочетание СД 2 типа и ХСН является распространенным синдромом, характеризующимся повышенным риском таких клинически значимых событий, как потребность в госпитализации и кардиоваскулярная смерть.…”

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Risk prediction of chronic heart failure in patients with type 2 diabetes

et al. 2021

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Introduction. Diabetes mellitus and chronic heart failure (CHF) occur concomitantly, and each disease independently increases the risk for the other. In this connection, we studied the factors associated with CHF progression and proposed a mathematical model for assessing the prediction of the risk of CHF development, which can be applied in real clinical practice. Patients and methods. A total of 316 patients with DT2 were examined. The median age was 68 (63; 74) years. The levels of cystatin C, homocysteine, interleukin-6, and albumin/creatinine ratio were assessed in all patients with DT2. To evaluate the efficacy of this model, a retrospective analysis of patients’ medical records was carried out ("test sample"). The discriminant power (ROC) of the model in new cases of CHF was 0.91 (0.87; 1.00). Thus, it indicates a high predictive power of this method. Results. A model has been built to predict the likelihood of developing CHF in patients with DT2 (sensitivity 76.2%, specificity 73.3%). Conclusions. This model will allow for accurate prediction of the likelihood of developing CHF in patients with DT2. Further studies are needed to use it for choosing the optimal tactics for managing these patients.

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Editorial: Heart Failure in Type 2 Diabetes – The “Forgotten” Complication

Cited by 5 publications

References 43 publications

Left Ventricular Diastolic Dysfunction in Type 2 Diabetes—Progress and Perspectives

Left Ventricular Diastolic Dysfunction in Type 2 Diabetes—Progress and Perspectives

The Indices of Nitric Oxide System in Rats with Carrageenan-Induced Enterocolitis Combined with Diabetes Mellitus

Risk prediction of chronic heart failure in patients with type 2 diabetes

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