The Indices of Nitric Oxide System in Rats with Carrageenan-Induced Enterocolitis Combined with Diabetes Mellitus

Krynytska, Іnna; Marushchak, Mariya

doi:10.2478/rjdnmd-2018-0033

Cited by 17 publications

(9 citation statements)

References 22 publications

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“…The toxic effect of NO is related both to its direct impact on iron-containing cellular enzymes and to the formation of peroxynitrite (ONOO-), a strong oxidant and a highly reactive/toxic free-radical compound, which is formed when NO interacts with the superoxide anion radical [30]. The toxic effect of ONOOprimarily manifests by inhibition of mitochondrial enzymes, leading to mitochondrial dysfunction and a reduction in ATP production [31].…”

Section: Discussionmentioning

confidence: 99%

Gender-Specific Differences of Oxidative Processes in the Population of Circulating Neutrophils of Rats in a Setting of Prolonged Administration of Monosodium Glutamate

Krynytska

Rutska

2019

Romanian Journal of Diabetes Nutrition and Metabolic Diseases

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Background and aims:Monosodium salt of glutamic acid (MSG) is one of the most common food additives. The aim of study was to assess, in gender-specific terms, how prolonged administration of MSG effects on reactive oxygen and nitrogen species formation and the apoptotic/necrotic processes in the population of rats circulating neutrophils. Material and methods: Experimental studies were conducted on 32 mature white rats. MSG was administered intragastrical at a dose of 30 mg/kg body weight for 30 days. The analysis of cell samples to determine neutrophils with overproduction of reactive oxygen species (ROS) and signs of apoptosis\necrosis was evaluated with flow laser cytometry method. The total nitric oxide synthase (NOS) activity was determined by monitoring the rate of conversion of L-arginine into citrulline. The total quantity of NO metabolites was assessed by evaluating of nitrite and nitrate ions. Results: We found a significant increase in generation of ROS, intensification of nitroxydergic processes, an increase in the percentage of apoptotic neutrophils and no changes in the percentage of necrotic neutrophils. Conclusions: We observed activation of oxidative and nitroxydergic processes in rats with prolonged administration of MSG, which initiate apoptosis. In gender-specific terms, a more pronounced changes were seen in male rats. key words: monosodium glutamate, reactive oxygen species, nitric oxide, NO-synthase; apoptosis.

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Section: Discussionmentioning

confidence: 99%

Gender-Specific Differences of Oxidative Processes in the Population of Circulating Neutrophils of Rats in a Setting of Prolonged Administration of Monosodium Glutamate

Krynytska

Rutska

2019

Romanian Journal of Diabetes Nutrition and Metabolic Diseases

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“…The first pilot projects on the development 25 . In the structure of non-infectious diseases mortality factors the main factors are diabetes [26][27][28] , cancer, chronic obstructive pulmonary diseases, cardiovascular diseases [29][30][31] . Key risk factors of non-infectious diseases are considered below (see scheme 1).…”

Section: Analysis Of Public Health System Formation In Ukrainementioning

confidence: 99%

Actual aspects of public health policy formation on the example of Ukraine

Demikhov

Dehtyarova

Demikhova

2020

Bangladesh J Med Sci

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Our publication is devoted to the evolution of the public health system, its role in public health promotion and determination of the basic notions. According to the definition of the World Health Organization, public health is a science and practice of the diseases prevention, increase in life expectancy and health promotion with the help of the organized actions of the society. Yet in practice, public health formed under difficult conditions. In the article we consider the following questions: stages of public health system formation in the world and in Ukraine; analysis of public health system formation in Ukraine: institutional frameworks and strategic priorities and basic operational public health functions in Ukraine. We propose suggestions on legal procedures state improvement in public health in Ukraine in the context of European integration. Bangladesh Journal of Medical Science Vol.19(3) 2020 p.358-364

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“…International Diabetes Federation, 415 million (1 in 11 people) suffer from diabetes; by 2040 this number will increase to 642 million or nearly 10% of the population [4,5].…”

Section: Romanian Journal Of Diabetes Nutrition and Metabolic Diseases mentioning

confidence: 99%

Comparative Study of the Effect of Various Forms of Quercetin on Experimental Diabetes

Посохова

Stechyshyn

Krynytska

et al. 2018

Romanian Journal of Diabetes Nutrition and Metabolic Diseases

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Background and aims: Diabetes mellitus (DM) is a multifactorial metabolic disorder characterized by hyperglycaemia caused by insulin deficiency or insulin resistance. It is a global public health problem. This study aimed to determine specific pharmacological effect of quercetin in water soluble and liposomal preparations in experimental diabetes mellitus. Material and methods: We examined the effect of Corvitin and Lipoflavone (at the dose of 10 mg / kg body weight) in a comparative study in white rats with type 1 diabetes and type 2 diabetes coupled with obesity. To simulate the forms of diabetes mellitus most analogous to those in humans we used Streptozotocin at the doses of 30 mg / kg and 50 mg / kg. We tested the levels of glucose, glycosylated hemoglobin, C-reactive protein, and interleukins 6 and 4 in the blood. Results: In animals with type 1 and type 2 diabetes Lipoflavone significantly reduces glucose and glycosylated hemoglobin levels compared to the rats treated with Corvitin. When administered to animals with diabetes, the effect of quercetin in liposomal form on the concentrations of IL-6, IL-4 and Creactive protein is also larger compared to the water-soluble form. Conclusions: Water soluble quercetin preparation Corvitin and to a larger extent liposomal preparation of this flavonoid, Lipoflavone, show anti-inflammatory effect and restore key parameters of carbohydrate metabolism in experimental type 1 diabetes mellitus and type 2 diabetes coupled with obesity, reducing blood glucose and glycosylated hemoglobin levels.

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The Indices of Nitric Oxide System in Rats with Carrageenan-Induced Enterocolitis Combined with Diabetes Mellitus

Cited by 17 publications

References 22 publications

Gender-Specific Differences of Oxidative Processes in the Population of Circulating Neutrophils of Rats in a Setting of Prolonged Administration of Monosodium Glutamate

Gender-Specific Differences of Oxidative Processes in the Population of Circulating Neutrophils of Rats in a Setting of Prolonged Administration of Monosodium Glutamate

Actual aspects of public health policy formation on the example of Ukraine

Comparative Study of the Effect of Various Forms of Quercetin on Experimental Diabetes

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