Ectopic vascularized bone formation by human mesenchymal stem cell microtissues in a biocomposite scaffold

Narayan, Rajan; Agarwal, Tarun; Mishra, Debasish; Maji, Somnath; Mohanty, Sujata; Mukhopadhyay, Asok; Maiti, Tapas K.

doi:10.1016/j.colsurfb.2017.10.004

Cited by 21 publications

(11 citation statements)

References 39 publications

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“…The implant-based scaffold requires surgical procedure to be applied to the infected bone. They are prepared by several techniques including lyophilization (Nair et al., 2015 ; Narayan et al., 2017 ), solvent casting (Siemann, 2005 ; Choudhury et al., 2015 ), particulate leaching (Phull et al., 2013 ; Sabzi et al., 2021 ) gas foaming (Teng et al., 2007 ; Diaz-Gomez et al., 2017 ), or electrospinning techniques (Frohbergh et al., 2012 ; Su et al., 2012 ). In a study by Zhou et al.…”

Section: Systems Under Investigation For the Local Delivery Of Antibiotic For Osteomyelitis Managementmentioning

confidence: 99%

Recent advances in the local antibiotics delivery systems for management of osteomyelitis

et al. 2021

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Section: Systems Under Investigation For the Local Delivery Of Antibiotic For Osteomyelitis Managementmentioning

confidence: 99%

Recent advances in the local antibiotics delivery systems for management of osteomyelitis

et al. 2021

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“…Inorganic compounds such as hydroxyapatite have been incorporated into polypyrrole composites to promote bone regeneration. Hydroxyapatite provides an osteoconductive and osteoinductive environment for the bone cells and improves their functional phenotypic characteristics [183][184][185] . Electrospun nanofibrous poly(butylene adipate-co-terephthalate) (PBAT)/polypyrrole scaffolds were fabricated and electrodeposited with hydroxyapatite.…”

Section: Bone Regenerationmentioning

confidence: 99%

Electroconductive multi-functional polypyrrole composites for biomedical applications

Zare

Agarwal

Zarepour

et al. 2021

Applied Materials Today

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“…Angiogenesis-related factors, such as vascular endothelial growth factor (VEGF) and hypoxia inducible factor (HIF) 1α, can significantly promote osteoblast differentiation and osteogenesis. Thus, effective vascularization is essential for promoting bone defect repair and functional restoration [16][17][18].…”

Section: Bone Tissue Engineeringmentioning

confidence: 99%

“…Bone engineering Nano-HA (1) In vitro study (2) In vivo glucocorticoid-induced bone defect model [28] In vitro study [29,33,154,155] In vivo ectopic osteogenesis study [18] In vivo calvarial defect model [20,99] Micro/Nano-structured surfaces of Cu x -HA (1) In vitro study (2) In vivo subcutaneously implant study [34] TCP nanolayers In vitro study [21] Nanofibrin In vitro study [24] GO In vivo calvarial defect study [22,26] In vivo ectopic osteogenesis study [27] PCL nanofibrous biomembranes In vivo maxillary bone lesion model [16] Mesoporous bioactive glass nanoparticles (1) In vitro study (2) In vivo ectopic osteogenesis study [30] Copper doped in electrospun bioactive glass nanofibers…”

Section: Nanomaterials Type Of Angiogenesis Assays Referencesmentioning

confidence: 99%

Insights into the angiogenic effects of nanomaterials: mechanisms involved and potential applications

Liu

Zhang

et al. 2020

J Nanobiotechnol

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The vascular system, which transports oxygen and nutrients, plays an important role in wound healing, cardiovascular disease treatment and bone tissue engineering. Angiogenesis is a complex and delicate regulatory process. Vascular cells, the extracellular matrix (ECM) and angiogenic factors are indispensable in the promotion of lumen formation and vascular maturation to support blood flow. However, the addition of growth factors or proteins involved in proangiogenic effects is not effective for regulating angiogenesis in different microenvironments. The construction of biomaterial scaffolds to achieve optimal growth conditions and earlier vascularization is undoubtedly one of the most important considerations and major challenges among engineering strategies. Nanomaterials have attracted much attention in biomedical applications due to their structure and unique photoelectric and catalytic properties. Nanomaterials not only serve as carriers that effectively deliver factors such as angiogenesis-related proteins and mRNA but also simulate the nano-topological structure of the primary ECM of blood vessels and stimulate the gene expression of angiogenic effects facilitating angiogenesis. Therefore, the introduction of nanomaterials to promote angiogenesis is a great helpful to the success of tissue regeneration and some ischaemic diseases. This review focuses on the angiogenic effects of nanoscaffolds in different types of tissue regeneration and discusses the influencing factors as well as possible related mechanisms of nanomaterials in endothelial neovascularization. It contributes novel insights into the design and development of novel nanomaterials for vascularization and therapeutic applications.

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Ectopic vascularized bone formation by human mesenchymal stem cell microtissues in a biocomposite scaffold

Cited by 21 publications

References 39 publications

Recent advances in the local antibiotics delivery systems for management of osteomyelitis

Recent advances in the local antibiotics delivery systems for management of osteomyelitis

Electroconductive multi-functional polypyrrole composites for biomedical applications

Insights into the angiogenic effects of nanomaterials: mechanisms involved and potential applications

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