Insights into the angiogenic effects of nanomaterials: mechanisms involved and potential applications

Liu, Wenjing; Zhang, Guilan; Wu, Junrong; Zhang, Yanli; Liu, Jia; Hy, Luo; Shao, Longquan

doi:10.1186/s12951-019-0570-3

Cited by 48 publications

(28 citation statements)

References 164 publications

(215 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It could release silicon ions and upregulate the expression of genes associated with angiogenesis and new tissue formation - [ 100] Hydrogel based on fayalite and NOCS…”

Section: Endothelial Cellsmentioning

confidence: 99%

Bioactive Materials Promote Wound Healing through Modulation of Cell Behaviors

Huang

et al. 2022

Advanced Science

107

View full text Add to dashboard Cite

Skin wound repair is a multistage process involving multiple cellular and molecular interactions, which modulate the cell behaviors and dynamic remodeling of extracellular matrices to maximize regeneration and repair. Consequently, abnormalities in cell functions or pathways inevitably give rise to side effects, such as dysregulated inflammation, hyperplasia of nonmigratory epithelial cells, and lack of response to growth factors, which impedes angiogenesis and fibrosis. These issues may cause delayed wound healing or even non-healing states. Current clinical therapeutic approaches are predominantly dedicated to preventing infections and alleviating topical symptoms rather than addressing the modulation of wound microenvironments to achieve targeted outcomes. Bioactive materials, relying on their chemical, physical, and biological properties or as carriers of bioactive substances, can affect wound microenvironments and promote wound healing at the molecular level. By addressing the mechanisms of wound healing from the perspective of cell behaviors, this review discusses how bioactive materials modulate the microenvironments and cell behaviors within the wounds during the stages of hemostasis, anti-inflammation, tissue regeneration and deposition, and matrix remodeling. A deeper understanding of cell behaviors during wound healing is bound to promote the development of more targeted and efficient bioactive materials for clinical applications.

show abstract

“…It could release silicon ions and upregulate the expression of genes associated with angiogenesis and new tissue formation - [ 100] Hydrogel based on fayalite and NOCS…”

Section: Endothelial Cellsmentioning

confidence: 99%

Bioactive Materials Promote Wound Healing through Modulation of Cell Behaviors

Huang

et al. 2022

Advanced Science

107

View full text Add to dashboard Cite

show abstract

“…In this study, it was reported that the CNTs have high sensitivity towards RSV through non bonded interactions which makes them a suitable drug carrier for safe and controlled release of RSV [ 97 ]. CNTs are also reported as carriers to deliver angiogenic factors to the ischemic tissues to promote angiogenesis [ 100 , 101 ].…”

Section: Application Of Cnms In Cardiovascular Tissue Engineeringmentioning

confidence: 99%

Carbon nanomaterials for cardiovascular theranostics: Promises and challenges

Alagarsamy

Mathan

Yan

et al. 2021

Bioactive Materials

View full text Add to dashboard Cite

Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Heart attack and stroke cause irreversible tissue damage. The currently available treatment options are limited to “damage-control” rather than tissue repair. The recent advances in nanomaterials have offered novel approaches to restore tissue function after injury. In particular, carbon nanomaterials (CNMs) have shown significant promise to bridge the gap in clinical translation of biomaterial based therapies. This family of carbon allotropes (including graphenes, carbon nanotubes and fullerenes) have unique physiochemical properties, including exceptional mechanical strength, electrical conductivity, chemical behaviour, thermal stability and optical properties. These intrinsic properties make CNMs ideal materials for use in cardiovascular theranostics. This review is focused on recent efforts in the diagnosis and treatment of heart diseases using graphenes and carbon nanotubes. The first section introduces currently available derivatives of graphenes and carbon nanotubes and discusses some of the key characteristics of these materials. The second section covers their application in drug delivery, biosensors, tissue engineering and immunomodulation with a focus on cardiovascular applications. The final section discusses current shortcomings and limitations of CNMs in cardiovascular applications and reviews ongoing efforts to address these concerns and to bring CNMs from bench to bedside.

show abstract

“…HA is widely used because it contains similar physical and chemical components to those of natural HA present in bone tissue [2]. Moreover, studies reported that HA induced a favorable immune response [7], exerted an angiogenic effect on defective bone tissue [8,9], and activated osteoblasts and osteoclasts for bone tissue remodeling by accelerating the differentiation of these cells [10,11].…”

Section: Introductionmentioning

confidence: 99%

Signaling Pathway and Transcriptional Regulation in Osteoblasts during Bone Healing: Direct Involvement of Hydroxyapatite as a Biomaterial

et al. 2021

View full text Add to dashboard Cite

Bone defects and periodontal disease are pathological conditions that may become neglected diseases if not treated properly. Hydroxyapatite (HA), along with tricalcium phosphate and bioglass ceramic, is a biomaterial widely applied to orthopedic and dental uses. The in vivo performance of HA is determined by the interaction between HA particles with bone cells, particularly the bone mineralizing cells osteoblasts. It has been reported that HA-induced osteoblastic differentiation by increasing the expression of osteogenic transcription factors. However, the pathway involved and the events that occur in the cell membrane have not been well understood and remain controversial. Advances in gene editing and the discovery of pharmacologic inhibitors assist researchers to better understand osteoblastic differentiation. This review summarizes the involvement of extracellular signal-regulated kinase (ERK), p38, Wnt, and bone morphogenetic protein 2 (BMP2) in osteoblastic cellular regulation induced by HA. These advances enhance the current understanding of the molecular mechanism of HA as a biomaterial. Moreover, they provide a better strategy for the design of HA to be utilized in bone engineering.

show abstract

Insights into the angiogenic effects of nanomaterials: mechanisms involved and potential applications

Cited by 48 publications

References 164 publications

Bioactive Materials Promote Wound Healing through Modulation of Cell Behaviors

Bioactive Materials Promote Wound Healing through Modulation of Cell Behaviors

Carbon nanomaterials for cardiovascular theranostics: Promises and challenges

Signaling Pathway and Transcriptional Regulation in Osteoblasts during Bone Healing: Direct Involvement of Hydroxyapatite as a Biomaterial

Contact Info

Product

Resources

About