Electroconductive multi-functional polypyrrole composites for biomedical applications

Zare, Ehsan Nazarzadeh; Agarwal, Tarun; Zarepour, Atefeh; Pinelli, Filippo; Zarrabi, Ali; Rossi, Filippo; Ashrafizadeh, Milad; Maleki, Aziz; Shahbazi, Mohammad‐Ali; Maiti, Tapas K.; Varma, Rajender S.; Tay, Franklin R.; Hamblin, Michael R.; Mattoli, Virgilio; Makvandi, Pooyan

doi:10.1016/j.apmt.2021.101117

Cited by 55 publications

(30 citation statements)

References 259 publications

(216 reference statements)

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“…A desirable tissue engineering scaffold should provide a microenvironment that includes suitable substrate topology and favorable mechanical, electrical, or biochemical properties 21 . The viability of HCE‐2 cells on the scaffolds and in vitro cytotoxicity analysis were characterized by the MTT assay for 1, 3, 5, and 7 days (Figure 8A).…”

Section: Resultsmentioning

confidence: 99%

“…Within nerve tissues, neurons quickly convey information in the form of electrical impulses; hence, the application of electrical stimulation at the site of nerve injury accelerates nerve regeneration and enhances the growth and proliferation of neural cells. 21,22 For instance, electrically conductive hyaluronic acid (HA) hydrogels incorporated with single-walled carbon nanotubes (CNTs) and PPy with high potential in promoting differentiation of human neural stem/progenitor cells were introduced by Shin et al 25 Electrical conduction also plays a significant role in bone tissue engineering. It is known that osteocytes are responsive to external electric fields.…”

Section: Introductionmentioning

confidence: 99%

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Conductive poly(ε‐caprolactone)/polylactic acid scaffolds for tissue engineering applications: Synergy effect of zirconium nanoparticles and polypyrrole

Jafari

Mirzaei

Shafiei

et al. 2022

Polymers for Advanced Techs

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Biocompatible and electrically conductive porous scaffolds with a desirable hydrophilicity and degradation rate and suitable mechanical performance are highly favorable for tissue engineering and regenerative medicine applications. In this study, we fabricated three-dimensional (3D) porous bioscaffolds from poly(ε-caprolactone) and polylactic acid containing different concentrations of zirconia nanoparticles (n-ZrO 2 ) through freeze-drying technique. Afterward, the surface of the scaffolds was coated with an electrically conductive layer through in situ polymerization of polypyrrole (PPy) on the samples. Bioscaffolds exhibited a favorable range of mechanical properties and electrical conductivity, meeting the required mechanical performances and conductivity for a broad range of tissue engineering applications. Coating PPy on the scaffolds resulted in significantly higher hydrophilicity and faster biodegradation rate, as well as a noticeable enhancement on the in vitro cell attachment, proliferation, and viability. Our findings indicated that the simultaneous presence of n-ZrO 2 and PPy in the system presents a noticeable synergistic effect in overall properties and introduces the fabricated 3D porous scaffolds as promising candidates for tissue engineering and regenerative medicine applications.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Conductive poly(ε‐caprolactone)/polylactic acid scaffolds for tissue engineering applications: Synergy effect of zirconium nanoparticles and polypyrrole

Jafari

Mirzaei

Shafiei

et al. 2022

Polymers for Advanced Techs

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show abstract

“…The fabrication of biopolymers such as silk, gelatin, collagen, nanocellulose, chitosan, PVA, and PVP in the wound care context is well-established with high values of biodegradability, renewability, environment-friendliness, non-cytotoxicity, good mechanical strength, low cost, and easy reproducibility [105][106][107]. On the one hand, natural polymers have been proven to be good candidates as skin scaffolds in wound healing since they mimic the components of extracellular matrix [108]. However, they are electrically inert with an absence of free electrons or ions, making them suitable as insulator polymers [109].…”

Section: Electroconductive Scaffoldmentioning

confidence: 99%

Wound Healing with Electrical Stimulation Technologies: A Review

2021

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Electrical stimulation (ES) is an attractive field among clinicians in the topic of wound healing, which is common yet complicated and requires multidisciplinary approaches. The conventional dressing and skin graft showed no promise on complete wound closure. These urge the need for the exploration of electrical stimulation to supplement current wound care management. This review aims to provide an overview of electrical stimulation in wound healing. The mechanism of galvanotaxis related to wound repair will be reviewed at the cellular and molecular levels. Meanwhile, different modalities of externally applied electricity mimicking a physiologic electric field will be discussed and compared in vitro, in vivo, and clinically. With the emerging of tissue engineering and regenerative medicine, the integration of electroconductive biomaterials into modern miniaturised dressing is of interest and has become possible with the advancing understanding of smart biomaterials.

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“…Polypyrrole (PPy) is a well-known CP that provides a high conductivity, fair redox properties, stability, facility of synthesis, and electroactivity in phosphate buffer (pH 7.4) [ [17] , [18] , [19] , [20] ]. In biosensors, PPy have been evaluated in different nanocomposites and morphologies, due to its promising properties in this area, achieving excellent analytical parameters, such as chitosan/PPy-NTs(polypyrrole nanotubes)/AuNPs [ 18 ], over-oxidized PPy-NTs/AuNPs [ 21 ], polypyrrole polymer containing epoxy active side groups (PPCE)[ 22 ] and PPy/reduced graphene oxide (RGO)[ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Development of polypyrrole (nano)structures decorated with gold nanoparticles toward immunosensing for COVID-19 serological diagnosis

Hryniewicz

Volpe

Bach-Toledo

et al. 2022

Materials Today Chemistry

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The rapid and reliable detection of SARS-CoV-2 seroconversion in humans is crucial for suitable infection control. In this sense, many studies have focused on increasing the sensibility, lowering the detection limits and minimizing false negative/positive results. Thus, biosensors based on nanoarchitectures of conducting polymers (CPs) are promising alternatives to more traditional materials, since they can hold improved surface area, higher electrical conductivity and electrochemical activity. In this work, we reported the analytical comparison of two different CPs morphologies for the development of an impedimetric biosensor to monitor SARS-CoV-2 seroconversion in humans. Biosensors based on polypyrrole (PPy), synthesized in both globular and nanotubular (NTs) morphology, and gold nanoparticles (AuNPs) are reported, using a self-assembly monolayer of 3-mercaptopropionic acid and covalently linked SARS-CoV-2 Nucleocapsid protein. Firstly, the novel hybrid materials were characterized by electron microscopy and electrochemical measurements, and the biosensor step-by-step construction was characterized by electrochemical and spectroscopic techniques. As a proof of concept, the biosensor was used for the impedimetric detection of anti-SARS-CoV-2 Nucleocapsid protein monoclonal antibodies. The results showed a linear response for different antibody concentrations, good sensibility and possibility to quantify 7.442 and 0.4 ng mL -1 of monoclonal antibody for PPy in the globular and nanotubular morphology, respectively. The PPy-NTs biosensor was able to discriminate serum obtained from COVID-19 positive vs negative clinical samples and is a promising tool for COVID-19 immunodiagnostic, which can contribute to further studies concerning rapid, efficient, and reliable detections.

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Electroconductive multi-functional polypyrrole composites for biomedical applications

Cited by 55 publications

References 259 publications

Conductive poly(ε‐caprolactone)/polylactic acid scaffolds for tissue engineering applications: Synergy effect of zirconium nanoparticles and polypyrrole

Conductive poly(ε‐caprolactone)/polylactic acid scaffolds for tissue engineering applications: Synergy effect of zirconium nanoparticles and polypyrrole

Wound Healing with Electrical Stimulation Technologies: A Review

Development of polypyrrole (nano)structures decorated with gold nanoparticles toward immunosensing for COVID-19 serological diagnosis

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