“…(8) Typical appearance characteristics of HED patients comprise sparse hair, wide and prominent forehead and chin, saddle nose, dry skin, skin pigmentation around the eyes and the mouth, vision and hearing problems, periorbital wrinkles, lip thickening, mandibular protrusion, and dished-in midface. (3,5,9,10) Moreover, HED patients suffer from sensitivity to heat and frequent high fevers due to the absence or the significant decrease of sweat glands. (5,10,11) It is worth mentioning that sweat glands are normal in Hidrotic ED patients.…”