Ecotoxicological potential of non-steroidal anti-inflammatory drugs (NSAIDs) in marine organisms: Bioavailability, biomarkers and natural occurrence in Mytilus galloprovincialis

Mezzelani, Marica; Gorbi, Stefania; Ros, Zaira Da; Fattorini, Daniele; d’Errico, Giuseppe; Milan, Massimo; Bargelloni, Luca; Regoli, Francesco

doi:10.1016/j.marenvres.2016.03.005

Cited by 114 publications

(41 citation statements)

References 36 publications

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“…A quantitative and software-assisted WOE model (Sediqualsoft) was applied to elaborate results of BaP bioavailability and biomarkers analyses and to summarize specific hazard indices. Whole calculations, detailed flow-charts, rationale for weights, thresholds, and expert judgments have been fully given elsewhere (Piva et al, 2011;Benedetti et al, 2012) and successfully applied to several multidisciplinary studies (Piva et al, 2011;Benedetti et al, 2012Benedetti et al, , 2014Benedetti et al, , 2016Avio et al, 2015;Bebianno et al, 2015;Mezzelani et al, 2016;Nardi et al, 2017).…”

Section: Statistical Analyses and Hazard Indices Evaluationmentioning

confidence: 99%

Microplastics as Vehicles of Environmental PAHs to Marine Organisms: Combined Chemical and Physical Hazards to the Mediterranean Mussels, Mytilus galloprovincialis

et al. 2018

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Pittura et al. Ecotoxicology of Microplastics in Marine Mussels of exposure. Molecular analyses confirmed the general lack of significant transcriptional variations of antioxidant and stress genes. The overall results suggest that microplastics induce a slight cellular toxicity under short-term (28 days) exposure conditions. However, modulation of immune responses, along with bioaccumulation of BaP, pose the still unexplored risk that these particles, under conditions of more chronic exposure (months to years) or interacting with other stressors, may provoke long-term, subtle effects on organisms' health status.

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Section: Statistical Analyses and Hazard Indices Evaluationmentioning

confidence: 99%

Microplastics as Vehicles of Environmental PAHs to Marine Organisms: Combined Chemical and Physical Hazards to the Mediterranean Mussels, Mytilus galloprovincialis

et al. 2018

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“…NSAIDs are the most widely used pharmaceuticals for humans and animals due to their analgesic, antipyretic, and anti-inflammatory properties [43], and these compounds have been previously detected at high concentrations in treated wastewater from WWTPs [44]. In the NSAID group, only flunixin, piroxicam, and indomethacin were detected in the snow samples.…”

Section: Nonsteroidal Anti-inflammatory Drugs (Nsaids)mentioning

confidence: 99%

Characterization, Source and Risk of Pharmaceutically Active Compounds (PhACs) in the Snow Deposition Near Jiaozhou Bay, North China

Peng

Song

et al. 2019

Applied Sciences

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The occurrence and distribution of 110 pharmaceutically active compounds (PhACs) were investigated in snow near Jiaozhou Bay (JZB), North China. All target substances were analyzed using solid phase extraction followed by liquid chromatography coupled to tandem mass spectrometry.A total of 38 compounds were detected for the first time in snow, including 23 antibiotics, eight hormones, three nonsteroidal anti-inflammatory drugs, two antipsychotics, one beta-adrenergic receptor and one hypoglycemic drug. The total concentration of PhACs in snow ranged from 52.80 ng/L to 1616.02 ng/L. The compounds found at the highest mean concentrations included tetracycline (125.81 ng/L), desacetylcefotaxime (17.73 ng/L), ronidazole (8.79 ng/L) and triamcinolone diacetate (2.84 ng/L). The contribution of PhACs in the vicinity of JZB to the PhACs in the snow is far greater than the contribution of those transmitted over a long distance. PhACs are mainly derived from drugs applied to local humans and animals. Based on the individual risk quotient (RQ) values, tetracycline poses high risks to the relevant aquatic organisms (algae and invertebrates). The rational application and scientific management of PhACs is an effective approach to reduce the ecological risks in JZB.

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“…Recent data showed that in the marine mussel (M. galloprovincialis Lam.) submicromolar concentrations of IBU are quickly bio-accumulated into soft tissues and can be easily found at ppb amounts in tissues of wild animals sampled in coastal areas during the touristic season (Mezzelani et al, 2016). These facts point to the necessity to test PhACs effects on non-target species at environmentally relevant concentrations.…”

Section: Molecular Adaptive Response To Ibumentioning

confidence: 99%

“…IBU effects in aquatic invertebrates was mainly assessed for sublethal toxicity using either common ecotoxicological or biomarker approaches (Contardo-Jara et al, 2011;Ericson et al, 2010;Fabbri et al, 2014;Bebianno, 2011, 2012;Matozzo et al, 2012;Mezzelani et al, 2016;Parolini et al, 2009Parolini et al, , 2011aParolini et al, , 2011bSerrano et al, 2015). Nowadays, new techniques such as transcriptomics offer a holistic viewpoint of the biological response to environmental stressors in aquatic organisms (Waters and Foster, 2004;Milan et al, 2013a).…”

Section: Introductionmentioning

confidence: 99%

Transcriptomic effects of the non-steroidal anti-inflammatory drug Ibuprofen in the marine bivalve Mytilus galloprovincialis Lam.

Maria

Amorim

Bebianno

et al. 2016

Marine Environmental Research

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The transcriptomic effects of Ibuprofen (IBU) in the digestive gland tissue of Mytilus galloprovincialis Lam. specimens exposed at low environmental concentrations (250 ng L(-1)) are presented. Using a 1.7 K feature cDNA microarray along with linear models and empirical Bayes statistical methods 225 differentially expressed genes were identified in mussels treated with IBU across a 15-day period. Transcriptional dynamics were typical of an adaptive response with a peak of gene expression change at day-7 (177 features, representing about 11% of sequences available for analysis) and an almost full recovery at the end of the exposure period. Functional genomics by means of Gene Ontology term analysis unraveled typical mussel stress responses i.e. aminoglycan (chitin) metabolic processes but also more specific effects such as the regulation of NF-κB transcription factor activity.

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Ecotoxicological potential of non-steroidal anti-inflammatory drugs (NSAIDs) in marine organisms: Bioavailability, biomarkers and natural occurrence in Mytilus galloprovincialis

Cited by 114 publications

References 36 publications

Microplastics as Vehicles of Environmental PAHs to Marine Organisms: Combined Chemical and Physical Hazards to the Mediterranean Mussels, Mytilus galloprovincialis

Microplastics as Vehicles of Environmental PAHs to Marine Organisms: Combined Chemical and Physical Hazards to the Mediterranean Mussels, Mytilus galloprovincialis

Characterization, Source and Risk of Pharmaceutically Active Compounds (PhACs) in the Snow Deposition Near Jiaozhou Bay, North China

Transcriptomic effects of the non-steroidal anti-inflammatory drug Ibuprofen in the marine bivalve Mytilus galloprovincialis Lam.

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