Ecofriendly microwave-assisted preparation, characterization and antitumor activity of some propylimidazolium-based Ionic liquids derivatives

Alqurashy, Bakhet A.

doi:10.1080/16583655.2020.1829395

Cited by 3 publications

(3 citation statements)

References 43 publications

(113 reference statements)

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“…The US method is often more energy efficient, easier to perform, requires less catalyst and solvent, [6] improves properties of synthesized compound [7] . MW‐assisted quaternization reactions improve yield by 10–15 % and dramatically reduces reaction time to a few munities [8,9] …”

Section: Introductionmentioning

confidence: 99%

“…[7] MW-assisted quaternization reactions improve yield by 10-15 % and dramatically reduces reaction time to a few munities. [8,9] Sorghum (Sorghum bicolor (L.) Moench) is the fifth most important grain crop and major staple food along with wheat, corn, rice, and barley. [10] The crop is commonly used to produce food, feed, and biofuel feedstock.…”

Section: Introductionmentioning

confidence: 99%

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Ultrasound‐ and Microwave‐promoted Synthesis, Growth‐regulating Activity and Antimicrobial Behavior of Trimecaine‐based Ionic Compounds

Dauletbakov

Zazybin

et al. 2022

ChemistrySelect

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The present work describes the synthesis, growth‐regulating activity, and antimicrobial behavior of ionic compounds based on 2‐diethylamino‐N‐(2,4,6‐trimethylphenyl)acetamide (trimecaine). Synthesis of ionic compounds was performed via N‐alkylation of trimecaine with alkyl halides using microwave and ultrasound activation and the results were compared with those of classical conditions (thermal activation). The synthesized ionic compounds have been tested for germination energy and capacity with the collection of different varieties and hybrids of sweet sorghum seeds. The valuable results were obtained for the seeds stored for several years for which the significant drop in germination activity is usually observed. Furthermore, the ionic compounds were used to study their biological activity – growth –regulating activity on sweet sorghum seeds and the antimicrobial behavior against E. coli, S. typhimurium, B. subtilis, S. aureus, P. aeruginosa, and C. albicans microorganisms.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ultrasound‐ and Microwave‐promoted Synthesis, Growth‐regulating Activity and Antimicrobial Behavior of Trimecaine‐based Ionic Compounds

Dauletbakov

Zazybin

et al. 2022

ChemistrySelect

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“…Microwave-assisted organic synthesis has been applied to organic reactions [1]. It becomes an environmental-friendly method to synthesize organic compounds due to the absence and less hazardous solvent used in its application [2]. Conventionally, organic reactions that could not undergo or take longer at room temperature due to the high activation energy required have been conducted through conductive heating with external heat sources.…”

Section: Introductionmentioning

confidence: 99%

Conventional and Microwave-Assisted Synthesis of 4’-Bromochalchone Utilizing 4-Bromoacetophenone and Benzaldehyde as Starting Material in Alkaline Condition

Narwanti

Afifah

2022

JKPK

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This study focuses on synthesizing 4’-bromochalcone through conventional and irradiation microwave methods to determine each method's time efficiency and yield. 4-Bromoacetophenone was treated with benzaldehyde in the presence of a base. Conventionally, the reaction mixture was stirred at room temperature. While in the microwave irradiation method, the reaction mixture was irradiated at a power of 140 watts. The compound was identified, including the melting point and physicochemical properties. The structure of the compound was confirmed by infrared, 1H- and 13C-nuclear magnetic resonance, and mass spectroscopy spectral data. The results showed that 4’-bromochalcone had been successfully synthesized using conventional and microwave irradiation methods in a good yield (94.61%±0.6793 and 89.39%±0.6418, consecutively). The structure assignment based on infrared, 1H- and 13C-nuclear magnetic resonance, and mass spectroscopy spectral data revealed that the synthesized product was 4’-bromochalcone. Synthesis of 4’-bromochalchone using microwave irradiation could be done in a shorter time than the conventional method.

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Microwave-assisted Synthesis of Heterocycles and their Anti-cancer Activities

Majhi,

Mondal

2023

CMIC

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One of the most efficient non-conventional heating methods is microwave irradiation. In organic synthesis, microwave irradiation has become a popular heating technique as it enhances product yields and purities, reduces reaction time from hours to minutes, and decreases unwanted side reactions. Microwave-assisted organic synthesis utilizes dielectric volumetric heating as an alternative activation method, which results in rapid and more selective transformations because of the uniform heat distribution. Heterocyclic compounds have a profound role in the drug discovery and development process along with their applications as agrochemicals, fungicides, herbicides, etc., making them the most prevalent form of biologically relevant molecules. Hence, enormous efforts have been made to flourish green routes for their high-yielding synthesis under microwave irradiation as a sustainable tool. Among the different clinical applications, heterocyclic compounds have received considerable attention as anti-cancer agents. Heterocyclic moieties have always been core parts of the development of anti-cancer drugs, including market-selling drugs, i.e., 5-fluorouracil, doxorubicin, methotrexate, daunorubicin, etc., and natural alkaloids, such as vinblastine and vincristine. In this review, we focus on the developments in the microwave-assisted synthesis of heterocycles and the anti-cancer activities of particular heterocycles.

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Ecofriendly microwave-assisted preparation, characterization and antitumor activity of some propylimidazolium-based Ionic liquids derivatives

Cited by 3 publications

References 43 publications

Ultrasound‐ and Microwave‐promoted Synthesis, Growth‐regulating Activity and Antimicrobial Behavior of Trimecaine‐based Ionic Compounds

Ultrasound‐ and Microwave‐promoted Synthesis, Growth‐regulating Activity and Antimicrobial Behavior of Trimecaine‐based Ionic Compounds

Conventional and Microwave-Assisted Synthesis of 4’-Bromochalchone Utilizing 4-Bromoacetophenone and Benzaldehyde as Starting Material in Alkaline Condition

Microwave-assisted Synthesis of Heterocycles and their Anti-cancer Activities

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