Ultrasound‐ and Microwave‐promoted Synthesis, Growth‐regulating Activity and Antimicrobial Behavior of Trimecaine‐based Ionic Compounds

Abstract

The present work describes the synthesis, growth‐regulating activity, and antimicrobial behavior of ionic compounds based on 2‐diethylamino‐N‐(2,4,6‐trimethylphenyl)acetamide (trimecaine). Synthesis of ionic compounds was performed via N‐alkylation of trimecaine with alkyl halides using microwave and ultrasound activation and the results were compared with those of classical conditions (thermal activation). The synthesized ionic compounds have been tested for germination energy and capacity with the collection of different varieties and hybrids of sweet sorghum seeds. The valuable results were obtained for the seeds stored for several years for which the significant drop in germination activity is usually observed. Furthermore, the ionic compounds were used to study their biological activity – growth –regulating activity on sweet sorghum seeds and the antimicrobial behavior against E. coli, S. typhimurium, B. subtilis, S. aureus, P. aeruginosa, and C. albicans microorganisms.

Stimulation of B-Lymphopoiesis by Administration of a Trimecaine-Based Ionic Compound in Cyclophosphamide-Induced Hematopoietic-Depressive Model

“…Trimecaine-based ionic compound (N,N-diethyl-N-(2-(mesitylamino)-2-oxoethyl) propan-1-aminium iodide) (TIC) was obtained by combining 2-(Diethylamino)-N-(2,4,6-trimethylphenyl) acetamide as the cationic part and propane iodide as the anionic part ( Figure 1 ). Chemical synthesis of the TIC compound is described in an earlier published chemical article [ 21 , 23 , 26 ]. The B-lymphopoiesis-stimulating activity of the TIC compound (analysis of proliferation pathways of bone marrow and spleen cells) was investigated and presented for the first time in this article.…”

“…At the same time, ionic compounds based on trimecaine have not been studied sufficiently, especially in terms of their pharmacological activity. The first reports on the leucopoiesis-stimulating and plant-growth-regulating activities of the ionic compounds based on trimecaine were published in [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ].…”